Research Groups

Mass Spectrometry at Dresdner Campus: A Road Map

MS Community Dresden:

The MS Community provides support to biological and clinical research projects carried at the Campus. It comprises MS-Facilities and MS-research groups from the MPI CBG, UKD, CMCB (TUD), CRTD and NCT, and Lipotype GmbH. The sites host more than 20 high-end MS instruments and have expertise in MS-based Lipidomics, Proteomics and Metabolomics. We work on service base and open for research collaborations. To our activities belong regular meetings, organization of ms-events, MS journal club and scientific consulting.

Events schedule

2021

MS4U Discussion club: Mass Cytometry

Host: Andrej Shevchenko
Speaker: Claudia Peitzsch
Topic: Introduction to the suspension mass cytometry method
Paper: https://www.nature.com/articles/s41467-021-22303-z
Date and time: 08.06.2020, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

MS4U Discussion club: Organoids Omics

Agenda:
1. Olya will talk about Lipidomics and Organoids  ~15 mins
2. Sofia will talk about Metabolomics and Organoids  ~15 mins
3. Ignacy will talk about Proteomics and Organoids  ~15 mins
4. Q&A and general discussion

Date and time: 01.06.2021 14:00
Location: ZOOM https://zoom.us/j/5587099875

Journal club

Host: Kai
Topic: A combined flow injection/reversed-phase chromatography-high-resolution mass spectrometry workflow for accurate absolute lipid quantification with 13C internal standards
Paper: https://pubs.rsc.org/en/content/articlehtml/2021/an/d0an02443k 
Date and time: 20.04.2021, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal club

Host: Andrej
Topic: Hybrid QconCAT-Based Targeted Absolute and Data-Independent Acquisition-Based Label-Free Quantification Enables In-Depth Proteomic Characterization of Wheat Amylase/Trypsin Inhibitor Extracts
Paper: https://pubs.acs.org/doi/full/10.1021/acs.jproteome.0c00752 
Date and time: 13.04.2021, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal club

Host: Olya
Topic: LIPIC: An Automated Workflow to Account for Isotopologue-Related Interferences in Electrospray Ionization High-Resolution Mass Spectra of Phospholipids
Paper: https://pubs.acs.org/doi/abs/10.1021/jasms.1c00008
Date and time: 06.04.2021, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

MS4U Discussion club: protein cross-linking

Agenda:
1. Overview of XL-MS methods: principles, limitations, software
2. Application
Guest stars: - Alexander von Appen (Alex starts his lab here in a few weeks) and Adrian Nievergelt (Pigino group) - will talk how XL-MS could foster their research
3. Q&A and general discussion

Host: MS Community
Topic: Protein cross-linking
Date and time: 23.03.2021 14:00
Location: ZOOM https://zoom.us/j/5587099875

 

Journal club

Host: Olya
Topic: AI-driven Deep Visual Proteomics defines cell identity and heterogeneity
Paper: https://www.biorxiv.org/content/10.1101/2021.01.25.427969v1.full.pdf
Date and time: 16.02.2021, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

 

MS4U Journal club

Host: Sarita Hebbar (Knust lab) and MS Community
Topic: Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes
Paper: https://www.pnas.org/content/pnas/115/34/E7978.full.pdf
Date and time: 02.02.2021, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

 

 

Omics Flash Talks 2021

Our annual get-together in the format of flash talks. Please join our friendly talks, share the news on your omics scientific landscape and stay connected.

Host: Andrej Shevchenko
Date and time: 26.01.2020, 14:00-17:00.
Location: ZOOM https://zoom.us/j/5587099875

14:00-14:05

Dr. Andrej Shevchenko

Welcome and introduction

 

14:05-14:15

Dr. Ignacy Rzagalinski

Fast-tracking QconCAT approach for absolute protein quantification

Shevchenko lab, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

14:15-14:25

Dr. Bharath Raghuraman

Absolute quantification: Pathway to proteome

14:25-14:35

Dr. Christian Klose

Lipotype's Highlights in 2020

Lipotype, Dresden, Germany

14:35-14:45

Nikolai Köhler, PhD researcher

Systemic Lipidome Alterations in HCC-induced Cachexia

Pauling lab, Computational Systems Medicine on Lipids and Metabolism,  Technical University Munich, Germany

14:45-14:55

BREAK  for coffee and chat

14:55-15:05

Tim Rose, PhD researcher &

Dr. Olga Vvedenskaya

Spartans project: subgroups of NAFL patients based on lipidomics

Pauling lab & Shevchenko lab

15:05-15:15

Anna TkachevPhD researcher

Extensive feature degenerecies in untargeted LC-MS experiments: how many lipid compounds are we quantifying?

Khaitovich lab, Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, Moscow, Russia

15:15-15:25

Aleskandra MitinaPhD researcher

Role of breast milk lipid composition in postnatal brain development

15:25 - 15:35

Dr. Matthias Pietzke

Towards a More Reliable Identification of Isomeric Metabolites Using Pattern Guided Retention Validation

Kempa lab, Proteomics and Metabolomics Platform, Max-Delbrück-Centrum for Molecular Medicine, Berlin, Germany

15:35-15:50

Dr. Christof Mitterer

Nano-pillar columns separation technique from Microfluidics

PharmaFluidics NV, Gent, Belgium

15:50-16:00

BREAK  for coffee and chat

16:00-16:10

Dr. Marcus Höring

Updates from Liebisch lab and future plans

Liebisch lab, Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany

16:10-16:20

Dr. Iqbal Mahmud

Unraveling Fusobacterium nucleatum Mediated Metabolic Pathway Alterations in Cancer Cells  using High Resolution Mass Spectrometry

Garrett Laboratory, Department of Pathology, Immunology, and Laboratory medicine, College of Medicine |University of Florida, FL, USA

16:20-16:30

Dr. Sofia Traikov

Metabolomics in Dresden Campus and future plans

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

16:30-16:40

Dr. Pia Hoenscheid

The national Covid project and future plans

National Center for Tumor Diseases, Dresden, Germany

16:40-16:45

Dr. Andrej Shevchenko

Closing remarks

 

 

Journal club

Host: Bharath
Topic: Quantitative shotgun proteome analysis by direct infusion
Paper: https://www.nature.com/articles/s41592-020-00999-z
Date and time: 19.01.2021, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

The JC rules are the following:

  1. The assigned person choses the paper in advance and sends it around, but does not present it.
  2. Most importantly, Everyone Reads the Paper!
  3. Starting person (randomly chosen) describes (questiones, criticizes) the first figure/paragraph/topic, and all together we try to figure out what authors wanted to say. The second person (randomly chosen) describes the second figure and so on.
  4. Please come if you read the paper.
  5. If you bring your colleagues or friends, make sure that they are aware of the rules.

For more information please contact

Olga Vvedenskaya

News

MS4U sessions and Journal Clubs will be on vacation till September 2021.

We will re-open on Tuesday, 21st of September.
The topic - "Summer Digest". We plan to exchange information on interesting MS-related articles published in July-August 2021. Format - flash talks 3 min maximum.
Details will be communicated closer to the date.

Email us in case of any questions.

 

MS Journal Club for Users (MS4U) series

This series is supported by Campus MS community, continues from November 2020.

New JC format aims to compensate absence of face-to-face meetings, and help scientists and medical crowd to to assess ms-based publications in their research field. It should also tighten contacts between scientific research community and analytics available at the Campus.

These monthly meetings will be helpful for you if
- you would like to know more about how exactly MS works
- you would like to know how MS technology can contribute to your research
- you would like to use certain MS method

 

in Media

[in German] https://www.nct-dresden.de/das-nctucc-dresden/newsroom/aktuelles.html

[in English] https://tu-dresden.de/tu-dresden/newsportal/news/tumor-characterization-using-mass-spectrometry-new-community-supports-research-projects-in-dresden