Mass Spectrometry at Dresdner Campus: A Road Map

MS Community Dresden:

The MS Community provides support to biological and clinical research projects carried at the Campus. It comprises MS-Facilities and MS-research groups from the MPI CBG, UKD, CMCB (TUD), CRTD and NCT, and Lipotype GmbH. The sites host more than 20 high-end MS instruments and have expertise in MS-based Lipidomics, Proteomics and Metabolomics. We work on service base and open for research collaborations. To our activities belong regular meetings, organization of ms-events, MS journal club and scientific consulting.

Events schedule

2023

MS Community Journal Club
Speaker: Simon Devos, VIB Ghent, Belgium
Topic: Beyond Massspec - New Generation Proteomics
Date: June 13th, Tue, 2pm CEST
Location: Zoom, TBA
Everybody welcome!

MS Community Journal Club
Speaker: Olya Vvedenskaya
Topic: Metabolomic profiles predict individual multidisease outcomes
Paper: https://www.nature.com/articles/s41591-022-01980-3
Date: June 6th, Tue, 2pm CEST
Location: https://eu01web.zoom.us/j/66739474186?pwd=WTR0eG41WGNZbmNYTnRpQ3l5cGJaQT09
Meeting ID: 667 3947 4186
Passcode: 670574
Everybody welcome!

Extraordinary MS Community session
Host: Marc Gentzel, TUD
Guests: Verena Tellström (Bruker Daltonics GmbH) and Richard Broadhead (Seer Inc)
Titles: Novel Tools in Proteomics and Clinical Biomarker Discovery
Date: May 3rd, 3pm, in-person
Location: Dresden Campus, Tatzberg 41, B Cube, Seminar Room E73/74
Everybody welcome!

MS Community Journal Club
Host: Marc Gentzel, CMCB TU Dresden
Speaker: Dr. Jan Bucek, Plasmion GmbH
Topic:  SICRIT ionization source - New Dimensions in Mass Spectrometry
Soft Ionization by Chemical Reaction in Transfer (SICRITis) a new plug-and-play ionization source for quantitative analyses on any-vendor LCMS systems. https://www.plasmion.de/products
Date: 18.04.2023 14:00 CET
Location: https://eu01web.zoom.us/j/62431670888?pwd=VHpmNDJCM2hkeWFBbmgxSkUxTEV0Zz09
Meeting ID: 624 3167 0888
Passcode: 129466

MS4U Journal Club Session
Everybody is welcome!
Speakers: Christian Klose (Lipotype) and Andrej Shevchenko (MPI CBG)
Topic: How gender impacts the lipidome?
Papers: https://pubmed.ncbi.nlm.nih.gov/36193934/, https://www.nature.com/articles/srep27710
Date: 28.03.2023, 14:00 CET
https://eu01web.zoom.us/j/69310145483?pwd=RWw3cUtrUUVZTUNaVVArQytISytaZz09
Meeting ID: 693 1014 5483
Passcode: 395398

Journal club
Speaker: Jonas Poehls (CSBD/CBG)
Topic: About weird and novel proteins
Paper: https://doi.org/10.1016/j.mcpro.2022.100480
Date: 21.03.2023, 14:00 CET
Location: MPI-CBG, Seminar Room 3

MS Community Journal Club
Host: Fedorova Lab, Center of Membrane Biochemistry and Lipid Research, TUD
Speaker: Zhixu Ni
Topic: Explore the dark forest of LipidA
Paper: https://doi.org/10.1021/acs.analchem.1c03566
Date: 14.03.2023 14:00 CET
https://eu01web.zoom.us/j/65172829327?pwd=NDRvL2FLSEFuVkJNKy9XNk9lMTVjdz09
Meeting ID: 651 7282 9327
Passcode: 683960


MS Community Journal Club
Host: Andrej Shevchenko
Speaker: Dr. Eduard Sabido, CRG Barcelona
Topic: Cloud based Quality Control System for Mass Spectrometry Laboratories
Paper: https://doi.org/10.1021/acs.jproteome.0c00853 and https://doi.org/10.1371/journal.pone.0189209
Date: 22.02.2023, 14:00 CET
Location: Zoom, https://eu01web.zoom.us/j/69536557484?pwd=SE1paGNaU3ArbUt3R2tpZTI0eVoyUT09
Meeting ID: 695 3655 7484
Passcode: 773823

Journal Club
Host: Vannur Garikapati
Topic: New Super-Resolution Mass Spec for Proteomics
Paper: https://pubs.acs.org/doi/10.1021/acs.analchem.2c04742
Date: 14.02.2023, 14:00 CET in-person
Location: MPI-CBG, Gallery

MS Community Journal Club
Host: Andrej Shevchenko
Speaker: Dale Cooper-Shepherd, Waters Inc.
Topic: Novel Hybrid Quadrupole-Multireflecting Time-of-Flight Mass Spectrometry System
https://doi.org/10.1021/jasms.2c00281
Date: 07.02.2023, 14:00 CET
Location: https://us02web.zoom.us/j/86267848379?pwd=LytnVTFSWWJvcGh0MnRnVUNxaFoyUT09
Meeting ID: 862 6784 8379
Passcode: 637141

Extraordinary MS Community session
Guest: Dr. Stephan Beil, CFEA coordinator, Faculty of Environmental Sciences TUD
Topic: Presentation of the new Core Facility Environmental Analytics (CFEA) at TUD
Date: Monday, 30.01.2023, 14:00 CET Zoom
Location: https://us02web.zoom.us/j/83508933360?pwd=MlA4Tk1KL1B6dk9Gemx6Y1V3eUR3QT09
Meeting ID: 835 0893 3360
Passcode: 976021

Journal Club
Host: Silvia Radrezza
Topic: pubs.acs.org/doi/abs/10.1021/acs.analchem.2c02042
Date: 24.01.2023 14:00 CET in-person
Location: MPI-CBG, Seminar Room 1

Journal Club
Host: Andrej Shevchenko
Topic: https://doi.org/10.1101/2022.08.26.505407
Date: 17.01.2023 14:00 CET in-person
Location: MPI-CBG, Seminar room #3

 

2022

X-Mass updates'22

This year we will host our FIFTH anniversary traditional get-together! X-Mass updates is an event that is open to all.

Host: Andrej Shevchenko
Date and time: 06.12.2022, 14:00-17:00 CET

Short overview: youtu.be/2bTtMl9BaO4

Time Speaker Affiliation Titles
14:00-14:05 Andrej Shevchenko Shevchenko Lab, MPI-CBG, Dresden Welcome
14:05-14:15 Silvia Radrezza Shevchenko Lab, MPI-CBG, Dresden Laser capture microdissection for spatial resolved lipidomics and proteomics
14:15-14:25 Christer Ejsing Ejsing Lab, SDU, Denmark An oral choline tolerance test with systems-level metabolic flux profiling
14:25-14:35 Zhixu Ni Fedorova Lab, ZMBL, TUD, Dresden Build your data analysis pipeline for lipidomcis
14:35-14:45 Robert Ahrends Ahrends Lab, University of Vienna, Austria Strategies for the exploration of large-scale lipidomics studies
14:45-14:55 Christian Klose Lipotype, Dresden Lipotype R&D updates 2022
14:55-15:10 Break breakout room for speakers session 1  
15:10-15:20 Bernhard Küster Küster Lab, TUM, Germany Proteome expression profiling in response to drugs by single-shot micro-LC-FAIMS-MS/MS
15:20-15:30 Alex von Appen von Appen Lab, MPI-CBG, Dresden Discovery-driven Structural Biology with Proteomics and AlphaFold
15:30-15:40 Ignacy Rzagalinski Shevchenko Lab, MPI-CBG, Dresden Absolute quantification of neurological protein markers by FastCAT workflow
15:40-15:50 Josch Pauling Pauling Lab, TUM, Germany All I want for Christmas: Smart Tools for lipidomics data analyses
15:50-16:00 Jens Rister Rister Lab, UMass Boston, US A fly eye therapy for vitamin A deficiency
16:00-16:15 Break breakout room for speakers session 2  
16:15-16:25 Anna Shevchenko Shevchenko Lab, MPI-CBG, Dresden Let it glow: Absolute Quantifcation of Fluorescent Proteins
16:25-16:35 Vadim Arshavsky Arshavski Lab, Duke University, US Simultaneous absolute quantification of multiple proteins from the photoreceptor outer segment
16:35-16:45 Canan Has Centogene, Germany Advancing rare disease patient diagnostics and treatment with multiomics
16:45-16:55 Yury Tsybin Spectroswiss, Switzerland Suspect-driven direct feature extraction in metabolomics and proteomics
16:55-17:00 Andrej Shevchenko Shevchenko Lab, MPI-CBG, Dresden Closing remarks

You can check the info about previous X-Mass updates below by selecting the year you are interested in.

Community Journal Club

Host: Mirko Peitzsch
Topic: Development of an Accurate Mass Retention Time Database for Untargeted Metabolomic Analysis and Its Application to Plasma and Urine Pediatric Samples
Paper: https://www.mdpi.com/1420-3049/26/14/4256/htm
Date and time: 22.11.2022, 14:00 CET.
Location: https://us02web.zoom.us/j/86402738879?pwd=bVh3U29ucmwrbmFXNUZ3b1NiVERqdz09

Community Journal Club

Host: Sofia Traikov
Topic: Analysis of endocannabinoids and cortisol in hairs
Speaker: Dr. Wei Gao (Biopsychology, TU Dresden)
Paper: doi: doi.org/10.1016/j.cca.2022.09.026 and doi.org/10.1016/j.pnpbp.2022.110658
Date and time: 15.11.2022, 14:00 CET.
Location: https://us02web.zoom.us/j/84144832724?pwd=bHRPaFFBeEY5UE5xTDBGRXpUZHNYUT09

The Lipidomics Webinar #9: CNS Regeneration

Speaker: Mikael Simons
Topic: Role of lipids in CNS regeneration
Date and time: 25.10.2022 17:00 CEST
More info and Registration: https://www.lipotype.com/lipidomics-webinars/role-of-lipids-in-central-nervous-system-regeneration/

Journal Club

Host: Vannur Garikapati
Topic: "Quantitative profiling of octadecanoids (oxylipins) using SFC-MS/MS and LC-MS/MS"
Paper: https://pubs.acs.org/doi/full/10.1021/acs.analchem.2c02601
Date and time: 18.10.2022, 14:00.
Location: Zoom https://us02web.zoom.us/j/83356276311?pwd=QnV0UHQxeHNGa2dBSFl0WkNnNVlyUT09
Meeting ID: 833 5627 6311
Passcode: 284374

MS Community Summer Digest

Host: MS Dresden Community and Marc Gentzel
Topic: Summer Digest
Paper: Let us know if you read anything cool!

#ms fundamentals: 10.1002/ange.202202165
#proteomics: 10.1021/acs.analchem.2c02777
#lipidomics: 10.1038/s41598-022-14690-0
#bioinformatics: 10.1038/s41592-022-01496-1
10.1186/s13059-022-02625-x
#metabolomics: 10.1002/anie.201904416

Date and time: 14.09.2022 14:00 CEST
Location: ZOOM https://zoom.us/j/5587099875

The Lipidomics Webinar #8: Plasma Membranes

Speaker: Ilya Levental
Topic: Composition, Organization & Function of Plasma Membranes
Date and time: 13.09.2022 17:00 CEST

More info and Registration: www.lipotype.com/lipidomics-webinars/composition-organization-and-function-of-plasma-membranes/

Journal Club

Host: Anna Shevchenko
Topic: Single-molecule protein sequencing
Paper: doi: 10.1063/5.0065509 and doi.org/10.1038/s41592-021-01143-1
Date and time: 12.07.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

The Lipidomics Webinar #7: Lipids and Obesity Pandemic

Speaker: Prof. Kai Simons
Topic: What Have Lipids to Do With the Worst Pandemic Ever?
Date and time: 29.06.2022 17:00

More info and Registration: www.lipotype.com/lipidomics-webinars/lipids-and-the-obesity-pandemic/

MS Community Journal Club

Host: Yuting Wang (former Shevchenko) and Maren Rudolph (Zeissig Group, TU Hospital/CRTD)
Topic: Clinical Lipidomics. Sortase A-cleavable CD1d identifies sphingomyelins as major class of CD1d-associated lipids.
Paper: https://www.frontiersin.org/articles/10.3389/fimmu.2022.897873/abstract
Date and time: 28.06.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal Club

Host: Ignacy Rzagalinski
Topic: Global Extraction from Parallel Reaction Monitoring to Quantify Background Peptides for Improved Normalization and Quality Control in Targeted Proteomics
Paper: https://pubs.acs.org/doi/10.1021/acs.analchem.1c01375?ref=pdf
Date and time: 14.06.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal Club

Host: Marc Gentzel (MS Facility, TU Dresren)
Speaker: Dr. Weißker/Dr.Roudini, Leibniz Institute for Solid State and Materials Research Dresden (IFW)
Topic: Nanotechnology and Aerosol Generation
Paper: https://pubs.rsc.org/en/content/articlelanding/2015/lc/c5lc00756a/unauth
Date and time: 18.05.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

The Lipidomics Webinar #6: Shotgun Lipidomics of Tissue Biopsies

Speaker: Andrej Shevchenko
Topic: Direct analysis of tissue biopsies could be in a better position to elucidate pathophysiological mechanisms than liquid biopsies.
Date and time: 17.05.2022 17:00
More info and Registration: https://www.lipotype.com/lipidomics-webinars/shotgun-lipidomics-of-tissue-biopsies

Video: youtu.be/reVBBEKdDIM

The Lipidomics Webinar #5: How to Yeast Lipidomics Research

Speaker: Christian Klose
Topic: Yeast is a powerful model system for cell and molecular biology research. What should be considered when conducting yeast lipidomics?
Date and time: 05.04.2022 17:00
More info and Registration: www.lipotype.com/how-to-yeast-lipidomics-research

Journal Club

Host: Maria Fedorova Lab
Topic: Achieving Absolute Molar Lipid Concentrations: A Phospholipidomics Cross-Validation Study
Paper: https://pubs.acs.org/doi/10.1021/acs.analchem.1c03743
Date and time: 22.03.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal Club

Host: Silvia Radrezza
Topic: Handheld Mass Spectrometer with Intelligent Adaptability for On-Site and Point-of-Care Analysis
Paper: https://doi.org/10.1021/acs.analchem.1c02508
Date and time: 15.03.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

The Lipidomics Webinar #4: How to Make Sense of Lipidomics Data

Speaker: Mathias Gerl
Topic: The amount and complexity of lipidomics data sets can be intimidating initially - but this does not need to be the case.
Date and time: 24.02.2022 17:00
More info and Registration: www.lipotype.com/lipidomics-webinars/how-to-make-sense-of-lipidomics-data

MS4U Discussion club

Host: Jonas Pohls (Agnes Toth-Petroczy/Shevchenko labs) and MS Community
Topic: Interplay between transcriptomics and proteomics
Paper: https://doi.org/10.1016/j.molcel.2020.03.031
Date and time: 22.02.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal Club

Host: Tobias Jumel
Topic: Does Data-Independent acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer's Disease
Paper: pubs.acs.org/doi/10.1021/acs.jproteome.1c00558
Date and time: 08.02.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal Club

Host: Kai Schuhmann
Topic: Nontargeted High-Resolution Mass Spectrometric Workflow for the Detection of Butyrylcholinesterase-Derived Adducts with Organophosphorus Toxicants and Structural Characterization of Their Phosphyl Moity after In-Source Fragmentation
Paper: pubs.acs.org/doi/abs/10.1021/acs.analchem.1c04116
Date and time: 25.01.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

The JC rules are the following:

  1. The assigned person choses the paper in advance and sends it around, but does not present it.
  2. Most importantly, Everyone Reads the Paper!
  3. Starting person (randomly chosen) describes (questiones, criticizes) the first figure/paragraph/topic, and all together we try to figure out what authors wanted to say. The second person (randomly chosen) describes the second figure and so on.
  4. Please come if you read the paper.
  5. If you bring your colleagues or friends, make sure that they are aware of the rules.

For more information please contact

Olga Vvedenskaya

News

May 2023
Fedorova lab, Shevchenko lab & Lipotype team attend the 54th DGMS conference in Dortmund. Four talks and numerous poster presentations from Dresden MS community.

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MS Journal Club for Users (MS4U)

MS4U was launched in 2020 to build a bridge between MS Community and scientists working in biological and clinical research at Dresdner campus. Here we discuss articles selected by YOU.
You found a hot paper related to your scientific topic but...
- do not understand ms-method?
- unsure if it fosters YOUR project?
- unclear if this is routine or only runs in a single lab?
- and, how it practically works?
Once you suggest an article or topic, we will look for complementary articles published by leading practitioners in this field and then analyze them together with you. MS-Lipidomics, MS-proteomics, MS-metabolomics, MS-imaging, any MS - let's discuss it with MS-Profis from the entire Dresden campus!
Submit YOUR HOT PAPER suggestion by clinical.lipidomics@mpi-cbg.de