We use shotgun lipidomics to better understand the metabolism in liver in normal and pathological conditions and pursue three major research avenues:
Veera Raghavan Thangapandi, Oskar Knittelfelder, Mario Brosch, Eleonora Patsenker, Olga Vvedenskaya, Stephan Buch, Sebastian Hinz, Alexander Hendricks, Marina Nati, Alexander Herrmann, Devavrat Ravindra Rekhade, Thomas Berg, Madlen Matz-Soja, Klaus Huse, Edda Klipp, Josch K Pauling, Judith Ah Wodke, Jacobo Miranda Ackerman, Malte von Bonin, Elmar Aigner, Christian Datz, Witigo von Schönfels, Sophie Nehring, Sebastian Zeissig, Christoph Röcken, Andreas Dahl, Trian Chavakis, Felix Stickel, Andrej Shevchenko, Clemens Schafmayer, Jochen Hampe, Pallavi Subramanian
Loss of hepatic Mboat7 leads to liver fibrosis.
Gut, Art. No. doi: 10.1136/gutjnl-2020-320853 (2020)
DOI
Eugenia Marbach-Breitrück, Madlen Matz-Soja, Ute Abraham, Wolfgang Schmidt-Heck, Susanne Sales, Christiane Rennert, Matthias Kern, Susanne Aleithe, Luise Spormann, Carlo Thiel, Raffaele Gerlini, Katrin Arnold, Nora Klöting, Reinhard Guthke, Damjana Rozman, Raffaele Teperino, Andrej Shevchenko, Achim Kramer, Rolf Gebhardt
Tick-tock hedgehog-mutual crosstalk with liver circadian clock promotes liver steatosis.
J Hepatol, 70(6) 1192-1202 (2019)
DOI
Christiane Rennert, Sebastian Vlaic, Eugenia Marbach-Breitrück, Carlo Thiel, Susanne Sales, Andrej Shevchenko, Rolf Gebhardt, Madlen Matz-Soja
The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism - A Systems Biology Analysis Using Self-Organizing Maps.
Front Physiol, 9 Art. No. 1180 (2018)
DOI
Oskar Knittelfelder, Sofia Traikov, Olga Vvedenskaya, Andrea Schuhmann, Sandra Segeletz, Anna Shevchenko, Andrej Shevchenko
Shotgun Lipidomics Combined with Laser Capture Microdissection: A Tool To Analyze Histological Zones in Cryosections of Tissues.
Anal Chem, 90(16) 9868-9878 (2018)
DOI
Jan Böttger, Katrin Arnold, Carlo Thiel, Christiane Rennert, Susanne Aleithe, Ute Hofmann, Sebastian Vlaic, Susanne Sales, Andrej Shevchenko, Madlen Matz-Soja
RNAi in murine hepatocytes: the agony of choice-a study of the influence of lipid-based transfection reagents on hepatocyte metabolism.
Arch Toxicol, 89(9) 1579-1588 (2015)
DOI
Matthias Kern, Joanna Kosacka, Nico Hesselbarth, Julia Brückner, John T Heiker, Gesine Flehmig, Ingrid Klöting, Peter Kovacs, Madlen Matz-Soja, Rolf Gebhardt, Knut Krohn, Susanne Sales, Kerstin Abshagen, Andrej Shevchenko, Michael Stumvoll, Matthias Blüher, Nora Klöting
Liver-restricted repin1 deficiency improves whole-body insulin sensitivity, alters lipid metabolism, and causes secondary changes in adipose tissue in mice.
Diabetes, 63(10) 3295-3309 (2014)
DOI
Hample lab, Coskun lab, Klipp lab, Pauling lab and LiSyM
Matz-Soja lab Cramer lab
Contact: olga.vvedenskaya(at)mpi-cbg.de