Mass Spectrometry at Dresdner Campus: A Road Map

MS Community Dresden:

The MS Community provides support to biological and clinical research projects carried at the Campus. It comprises MS-Facilities and MS-research groups from the MPI CBG, UKD, CMCB (TUD), CRTD and NCT, and Lipotype GmbH. The sites host more than 20 high-end MS instruments and have expertise in MS-based Lipidomics, Proteomics and Metabolomics. We work on service base and open for research collaborations. To our activities belong regular meetings, organization of ms-events, MS journal club and scientific consulting.

Events schedule

2022

X-Mass updates'22

This year we will host our FIFTH anniversary traditional get-together! X-Mass updates is an event that is open to all. We will announce the speakers soon. Stay tuned!Host: Andrej Shevchenko
Date and time: 06.12.2022, 14:00-17:00 CET
Location: online, Zoom TBA

Time Speaker Affiliation Titles
14:00-14:05 Andrej Shevchenko Shevchenko Lab, MPI-CBG, Dresden Welcome
14:05-14:15 Silvia Radrezza Shevchenko Lab, MPI-CBG, Dresden Laser capture microdissection for spatial resolved lipidomics and proteomics
14:15-14:25 Christer Ejsing Ejsing Lab, SDU, Denmark An oral choline tolerance test with systems-level metabolic flux profiling
14:25-14:35 Zhixu Ni Fedorova Lab, ZMBL, TUD, Dresden Build your data analysis pipeline for lipidomcis
14:35-14:45 Robert Ahrends Ahrends Lab, University of Vienna, Austria Strategies for the exploration of large-scale lipidomics studies
14:45-14:55 Christian Klose Lipotype, Dresden Lipotype R&D updates 2022
14:55-15:10 Break breakout room for speakers session 1  
15:10-15:20 Bernhard Küster Küster Lab, TUM, Germany Proteome expression profiling in response to drugs by single-shot micro-LC-FAIMS-MS/MS
15:20-15:30 Alex von Appen von Appen Lab, MPI-CBG, Dresden Discovery-driven Structural Biology with Proteomics and AlphaFold
15:30-15:40 Ignacy Rzagalinski Shevchenko Lab, MPI-CBG, Dresden Absolute quantification of neurological protein markers by FastCAT workflow
15:40-15:50 Josch Pauling Pauling Lab, TUM, Germany All I want for Christmas: Smart Tools for lipidomics data analyses
15:50-16:00 Jens Rister Rister Lab, UMass Boston, US A fly eye therapy for vitamin A deficiency
16:00-16:15 Break breakout room for speakers session 2  
16:15-16:25 Anna Shevchenko Shevchenko Lab, MPI-CBG, Dresden Let it glow: Absolute Quantifcation of Fluorescent Proteins
16:25-16:35 Vadim Arshavsky Arshavski Lab, Duke University, US Simultaneous absolute quantification of multiple proteins from the photoreceptor outer segment
16:35-16:45 Canan Has Centogene, Germany Advancing rare disease patient diagnostics and treatment with multiomics
16:45-16:55 Yury Tsybin Spectroswiss, Switzerland Suspect-driven direct feature extraction in metabolomics and proteomics
16:55-17:00 Andrej Shevchenko Shevchenko Lab, MPI-CBG, Dresden Closing remarks

You can check the info about previous X-Mass updates below by selecting the year you are interested in.

Community Journal Club

Host: Mirko Peitzsch
Topic: Development of an Accurate Mass Retention Time Database for Untargeted Metabolomic Analysis and Its Application to Plasma and Urine Pediatric Samples
Paper: https://www.mdpi.com/1420-3049/26/14/4256/htm
Date and time: 22.11.2022, 14:00 CET.
Location: https://us02web.zoom.us/j/86402738879?pwd=bVh3U29ucmwrbmFXNUZ3b1NiVERqdz09

Community Journal Club

Host: Sofia Traikov
Topic: Analysis of endocannabinoids and cortisol in hairs
Speaker: Dr. Wei Gao (Biopsychology, TU Dresden)
Paper: doi: doi.org/10.1016/j.cca.2022.09.026 and doi.org/10.1016/j.pnpbp.2022.110658
Date and time: 15.11.2022, 14:00 CET.
Location: https://us02web.zoom.us/j/84144832724?pwd=bHRPaFFBeEY5UE5xTDBGRXpUZHNYUT09

The Lipidomics Webinar #9: CNS Regeneration

Speaker: Mikael Simons
Topic: Role of lipids in CNS regeneration
Date and time: 25.10.2022 17:00 CEST
More info and Registration: https://www.lipotype.com/lipidomics-webinars/role-of-lipids-in-central-nervous-system-regeneration/

Journal Club

Host: Vannur Garikapati
Topic: "Quantitative profiling of octadecanoids (oxylipins) using SFC-MS/MS and LC-MS/MS"
Paper: https://pubs.acs.org/doi/full/10.1021/acs.analchem.2c02601
Date and time: 18.10.2022, 14:00.
Location: Zoom https://us02web.zoom.us/j/83356276311?pwd=QnV0UHQxeHNGa2dBSFl0WkNnNVlyUT09
Meeting ID: 833 5627 6311
Passcode: 284374

MS Community Summer Digest

Host: MS Dresden Community and Marc Gentzel
Topic: Summer Digest
Paper: Let us know if you read anything cool!

#ms fundamentals: 10.1002/ange.202202165
#proteomics: 10.1021/acs.analchem.2c02777
#lipidomics: 10.1038/s41598-022-14690-0
#bioinformatics: 10.1038/s41592-022-01496-1
10.1186/s13059-022-02625-x
#metabolomics: 10.1002/anie.201904416

Date and time: 14.09.2022 14:00 CEST
Location: ZOOM https://zoom.us/j/5587099875

The Lipidomics Webinar #8: Plasma Membranes

Speaker: Ilya Levental
Topic: Composition, Organization & Function of Plasma Membranes
Date and time: 13.09.2022 17:00 CEST

More info and Registration: www.lipotype.com/lipidomics-webinars/composition-organization-and-function-of-plasma-membranes/

Journal Club

Host: Anna Shevchenko
Topic: Single-molecule protein sequencing
Paper: doi: 10.1063/5.0065509 and doi.org/10.1038/s41592-021-01143-1
Date and time: 12.07.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

The Lipidomics Webinar #7: Lipids and Obesity Pandemic

Speaker: Prof. Kai Simons
Topic: What Have Lipids to Do With the Worst Pandemic Ever?
Date and time: 29.06.2022 17:00

More info and Registration: www.lipotype.com/lipidomics-webinars/lipids-and-the-obesity-pandemic/

MS Community Journal Club

Host: Yuting Wang (former Shevchenko) and Maren Rudolph (Zeissig Group, TU Hospital/CRTD)
Topic: Clinical Lipidomics. Sortase A-cleavable CD1d identifies sphingomyelins as major class of CD1d-associated lipids.
Paper: https://www.frontiersin.org/articles/10.3389/fimmu.2022.897873/abstract
Date and time: 28.06.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal Club

Host: Ignacy Rzagalinski
Topic: Global Extraction from Parallel Reaction Monitoring to Quantify Background Peptides for Improved Normalization and Quality Control in Targeted Proteomics
Paper: https://pubs.acs.org/doi/10.1021/acs.analchem.1c01375?ref=pdf
Date and time: 14.06.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal Club

Host: Marc Gentzel (MS Facility, TU Dresren)
Speaker: Dr. Weißker/Dr.Roudini, Leibniz Institute for Solid State and Materials Research Dresden (IFW)
Topic: Nanotechnology and Aerosol Generation
Paper: https://pubs.rsc.org/en/content/articlelanding/2015/lc/c5lc00756a/unauth
Date and time: 18.05.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

The Lipidomics Webinar #6: Shotgun Lipidomics of Tissue Biopsies

Speaker: Andrej Shevchenko
Topic: Direct analysis of tissue biopsies could be in a better position to elucidate pathophysiological mechanisms than liquid biopsies.
Date and time: 17.05.2022 17:00
More info and Registration: https://www.lipotype.com/lipidomics-webinars/shotgun-lipidomics-of-tissue-biopsies

Video: youtu.be/reVBBEKdDIM

The Lipidomics Webinar #5: How to Yeast Lipidomics Research

Speaker: Christian Klose
Topic: Yeast is a powerful model system for cell and molecular biology research. What should be considered when conducting yeast lipidomics?
Date and time: 05.04.2022 17:00
More info and Registration: www.lipotype.com/how-to-yeast-lipidomics-research

Journal Club

Host: Maria Fedorova Lab
Topic: Achieving Absolute Molar Lipid Concentrations: A Phospholipidomics Cross-Validation Study
Paper: https://pubs.acs.org/doi/10.1021/acs.analchem.1c03743
Date and time: 22.03.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal Club

Host: Silvia Radrezza
Topic: Handheld Mass Spectrometer with Intelligent Adaptability for On-Site and Point-of-Care Analysis
Paper: https://doi.org/10.1021/acs.analchem.1c02508
Date and time: 15.03.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

The Lipidomics Webinar #4: How to Make Sense of Lipidomics Data

Speaker: Mathias Gerl
Topic: The amount and complexity of lipidomics data sets can be intimidating initially - but this does not need to be the case.
Date and time: 24.02.2022 17:00
More info and Registration: www.lipotype.com/lipidomics-webinars/how-to-make-sense-of-lipidomics-data

MS4U Discussion club

Host: Jonas Pohls (Agnes Toth-Petroczy/Shevchenko labs) and MS Community
Topic: Interplay between transcriptomics and proteomics
Paper: https://doi.org/10.1016/j.molcel.2020.03.031
Date and time: 22.02.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal Club

Host: Tobias Jumel
Topic: Does Data-Independent acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer's Disease
Paper: pubs.acs.org/doi/10.1021/acs.jproteome.1c00558
Date and time: 08.02.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

Journal Club

Host: Kai Schuhmann
Topic: Nontargeted High-Resolution Mass Spectrometric Workflow for the Detection of Butyrylcholinesterase-Derived Adducts with Organophosphorus Toxicants and Structural Characterization of Their Phosphyl Moity after In-Source Fragmentation
Paper: pubs.acs.org/doi/abs/10.1021/acs.analchem.1c04116
Date and time: 25.01.2022, 14:00.
Location: ZOOM https://zoom.us/j/5587099875

The JC rules are the following:

  1. The assigned person choses the paper in advance and sends it around, but does not present it.
  2. Most importantly, Everyone Reads the Paper!
  3. Starting person (randomly chosen) describes (questiones, criticizes) the first figure/paragraph/topic, and all together we try to figure out what authors wanted to say. The second person (randomly chosen) describes the second figure and so on.
  4. Please come if you read the paper.
  5. If you bring your colleagues or friends, make sure that they are aware of the rules.

For more information please contact

Olga Vvedenskaya

News

13 October 2022

Dr. Andrej Shevchenko and Prof. Dr. Kai Simons win DGKL award

For the development of the world’s first quantitative shotgun lipidomics platform

More info

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MS Journal Club for Users (MS4U)

MS4U was launched in 2020 to build a bridge between MS Community and scientists working in biological and clinical research at Dresdner campus. Here we discuss articles selected by YOU.
You found a hot paper related to your scientific topic but...
- do not understand ms-method?
- unsure if it fosters YOUR project?
- unclear if this is routine or only runs in a single lab?
- and, how it practically works?
Once you suggest an article or topic, we will look for complementary articles published by leading practitioners in this field and then analyze them together with you. MS-Lipidomics, MS-proteomics, MS-metabolomics, MS-imaging, any MS - let's discuss it with MS-Profis from the entire Dresden campus!
Submit YOUR HOT PAPER suggestion by clinical.lipidomics@mpi-cbg.de