Veranstaltungen & Vorträge Kalendar

Hier finden Sie eine Übersicht zu allen öffentlichen wissenschaftlichen Vorträgen und Veranstaltungen, sowie zu Veranstaltungen für die Öffentlichkeit am MPI-CBG. Nicht-öffentliche Vorträge werden im Intranet des Instituts bekanntgegeben. Umfassende Information zu Vorträgen und Workshops an weiteren Dresdner Wissenschaftseinrichtungen finden Sie im Dresden Science Calendar.

Aktuelle Veranstaltungen

Aktuelle Vorträge

  • May 20, 2026 14:00 - 15:00

    Using targeted manipulation of cell adhesion to study tissue properties during morphogenesis

    Gerald Lerchbaumer

    University of Toronto, Canada

    CBG SR 4

    Host: Rita Mateus

    Physics of Living Systems

    Abstract

    Cell adhesion is essential for shaping tissues during animal development, yet how adhesion is tuned to support different morphogenetic movements remains unclear. We used optogenetics in the Drosophila embryo to address this question by enhancing clustering of E-cadherin, a core component of adherens junctions. Increasing E-cadherin clustering enriches E-cadherin at junctions and reduces its mobility, consistent with enhanced adhesion strength. This approach allows targeted manipulation of cellular adhesive properties in vivo and makes it possible to address questions that were previously difficult to test directly. By analyzing animal development while increasing cell adhesion throughout the epithelial tissue, we found that this causes a strong reduction in cell rearrangements during epithelial morphogenesis and disrupts convergent extension of the embryonic axis. To further understand these effects, we adapted a vertex model to include adhesion-dependent friction between cells. The model predicts that stronger adhesion increases resistance to neighbor exchange and thereby limits tissue remodeling. To test this idea, we analyzed different morphogenetic movements in the fly and their dependence on cell adhesion. We found that enhanced E-cadherin clustering strongly slows morphogenetic processes that depend on both cell shape change and cell rearrangement, while movements that rely primarily on apical constriction can still proceed. Together, these findings suggest that E-cadherin clustering is an important regulator of tissue mechanics and that tuning adhesion is critical for morphogenetic events that require dynamic cell-cell rearrangements

  • May 21, 2026 11:00 - 12:00

    TBA

    Jacqueline Tabler

    Max Planck Institute of Cell Biology and Genetics

    CBG Large Auditorium

    Host: Stephan Grill

    Molecular and Cellular Systems Organoids and Organisms

    Abstract

    TBA

  • Jun 11, 2026 11:00 - 12:00

    Chemical Precision Tools to Dissect Protein Glycosylation

    Benjamin Schumann

    TU Dresden

    CBG Large Auditorium

    Host: André Nadler

    Abstract

    Alterations in glycoprotein expression and composition are an undisputed corollary of developmental processes, host-pathogen interactions and cancer formation. Consequently, some of the most important tumor biomarkers are heavily glycosylated. Understanding cellular glycoproteome changes is paramount but hampered by experimental limitations. Protein glycosylation is mediated by the activities of >200 glycosyltransferases mainly located in the secretory pathway. Since these transferases are interdependent through compensation and competition, traditional methods of molecular cell biology fail to fully address the complexity of glycoprotein biosynthesis. Furthermore, workflows in mass spec-glycoproteome analysis are often restricted to isolated cell lines that do not adequately reflect the interactions within tissues or between tumor and microenvironment. Thus, we lack strategies to understand 1) the protein substrate specificities of individual glycosyltransferases and 2) which glycoproteins are made by cells in response to their microenvironment. We also 3) miss chemical probes to investigate and disrupt cancer-relevant glycosylation. Here, I describe our development of chemical “Precision Tools” to dissect cellular glycosylation. We employ bump-and-hole (BH) engineering to render glycosyltransferases receptive to a chemically modified nucleotide-sugar substrate that carries a bioorthogonal tag and is not used by wildtype transferases. Engineering individual transferases allows differential profiling of their protein substrate specificities. We found that establishing cellular BH systems required innovation in the delivery of corresponding nucleotide-sugarsto the secretory pathway. We have also taken initiative in the development of small molecule inhibitors against cancer-relevant glycosylation enzymes. Thus, chemical Precision Tools allow us to profile protein glycosylation as a key player in cancer biology.

  • Sep 17, 2026 11:00 - 12:00

    TBA

    Takashi Hiiragi

    Hubrecht Institute, Netherlands

    CBG Large Auditorium

    Host: Augusto Ortega Granillo and Jonathan Jackson

  • Sep 24, 2026 11:00 - 12:00

    TBA

    Maria Elena Torres-Padilla

    Helmholtz Zentrum München, Germany

    CBG Large Auditorium

    Host: Merixtell Huch

  • Oct 29, 2026 11:00 - 12:00

    TBA

    Katharina Sonnen

    Hubrecht Institute, Netherlands

    CBG Large Auditorium

    Host: Rita Mateus

    Molecular and Cellular Systems Organoids and Organisms Physics of Living Systems

  • Nov 5, 2026 00:00 - 00:05

    TBA

    Anne-Claude Gavin

    University of Geneva, Switzerland

    CBG Large Auditorium

    Host: Martin Buitrago Arango and Koichiro Takenaka

    Molecular and Cellular Systems Organoids and Organisms

    Abstract

    TBA

  • Nov 12, 2026 11:00 - 12:00

    TBA

    Madeline Lancaster

    University of Cambridge

    CBG Large Auditorium

    Host: Claudia Gerri

  • Dec 3, 2026 11:00 - 12:30

    TBA

    Martin Beck

    Max Planck Institute of Biophysics, Germany

    CBG Large Auditorium

    Host: Alexander von Appen

    Molecular and Cellular Systems Physics of Living Systems Organoids and Organisms

  • Dec 10, 2026 11:00 - 12:00

    TBA

    David Pellman

    Harvard Medical School, USA

    CBG Large Auditorium

    Host: Alexander von Appen