Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads
Epithelial cells share their apical surfaces to form a tubular lumen in many organs. In the liver, however, hepatocytes share…
An endosomal tether undergoes an entropic collapse to bring vesicles together
An early step in intracellular transport is the selective recognition of a vesicle by its appropriate target membrane, a…
Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale
Delivery of exogenous mRNA using lipid nanoparticles (LNP) is a promising strategy for therapeutics.…
How do subcellular structures shape cellular morphology (and vice-versa)? At a completely different length scale, membrane bound organelles also have stereotypical size and shape. This, together…
How do organs measure and control their size? This is a crucial question that has remained long unresolved in Biology. We aim to answer it by looking at cells. We are focused on studying…
To form an adult body with stereotyped morphology, the size of an organism crosses many orders of magnitude. Its underlying tissues and cells mediate how much and how fast growth will occur: growth…
We use the zebrafish larva as an in vivo vertebrate model, as it allows for optimal quantitative live imaging and amenable genetics. Importantly, zebrafish regenerate their organs! This allows us…
Growth across scales: Dynamic signaling impacts tissue size and shape
Organ and tissue growth result from an integration of biophysical communication across biological scales, both in time and…
