Clinical Variant Assessment
Assessing the phenotypic effects of single nucleotide variants remains a challenge even in genes with well-established clinical impact. We have developed DeMAG…
OmniSEC TDA max Malvern – SEC-SLS
an analytical size-exclusion chromatography system combined with a static light scattering detector for determining sample monodispersity at a higher level as…
Barbara Borgonovo – Head of Protein Characterisation
Barbara joined the Institute in 2006 and oversees all equipment and the biophysical technologies of the Facility. She studied Biology in Milan,…
Zetasizer ZSP Malvern – DLS
Evaluate the monodispersity and hydrodynamic radius of your sample, e.g., proteins or liposomes, by measuring the diffusion coefficient obtained by dynamic light…
Chirascan Applied Photophysics – Circular Dichroism
For measuring the secondary structure content, e.g., alpha-helices, beta-sheet, and disordered regions, of your target protein. Allows to assess…
Prometheus NanoTemper – nanoDSF
for label-free determination of the melting temperature and stability of your target protein. Allows to scout buffer conditions for optimal protein stability,…
Refeyn Two – mass photometer
for measuring the molecular weight between 30 kDa up to 5 MDa of purified proteins, DNA, or complexes composed of protein, DNA, and/or lipids. Allows the determination…
Knauer Azura with fluorescence detector – FSEC
automated analytical FPLC system with autosampler, dual wavelength fluorescence detector, and fraction collector. Allows the evaluation of protein…
Fastprep
for mechanical lysis using bead-beating of diverse biological materials, such as cell pellets and hard tissues. For sample volumes below 0.5 ml. Allows simultaneous processing of 24…
LM20 (Microfluidics)
for mechanical lysis of cells from bacterial, yeast, insect, or mammalian origin. Can reach pressures up to 32k psi and allows throughput of volumes between 50 and 500 ml.
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