Prion-like proteins in Dictyostelium discoideum
Many compartment-forming proteins carry prion-like domains, which cause neurodegeneration and protein misfolding diseases in humans. However, why do…
Future Plans:
In the future, we aim to firmly establish that changes in the cytosolic pH regulate a liquid to solid phase transition of the cytoplasm. We further aim to determine the structure of…
The chemistry and physics of dormancy
How does the cytoplasm change under starvation conditions and how do cells survive and recover from starvation? Our recent findings suggest that the eukaryotic…
Future Plans:
Our primary goal is to study the phase behavior of several RNP granule-associated proteins and RNAs in vitro. Relying on such in vitro experiments and using a recently established…
RNP granules and cross-talk with the protein quality control machinery
Stress-inducible RNP granules form as a response to external stress and are associated with the protein quality control (PQC)…
Prion-like proteins and the formation of liquid-like compartments
Proteins containing intrinsically disordered domains of low sequence complexity (also called prion-like proteins when they mostly…
Future Plans:
To find out whether our findings extend to other proteins, we aim to investigate the phase behavior of additional disease-associated prion-like proteins. We will also study the…
