Organoids and Organisms

At the MPI-CBG we investigate how cells form tissues and organs, how these structures maintain and regenerate themselves, and how such processes change across development, age, and evolution. Our researchers combine studies in model organisms with advanced in vitro models to uncover the principles underlying tissue organization, morphogenesis, regeneration, and disease.

We study development and regeneration across a range of classical and emerging model systems, such as invertebrate species like Drosophila melanogaster and Caenorhabditis elegans, as well as vertebrate systems including zebrafish, mice and quail. These living systems enable the exploration of complex interactions within and between tissues that are not yet fully replicable in vitro. At the same time, we are advancing animal and human stem-cell- and tissue-derived organoids as well as embryonic organoids (“stembryos”) as powerful tools to study organ formation, tissue renewal, regeneration and disease mechanisms outside of the body. These 3D structures provide insights into cell biological processes and development by allowing us to reconstruct organ architecture and function, dissect cellular behaviors, model tissue repair and disease initiation and progression.

Our research spans topics such as fetal–maternal tissue communication, endomembrane dynamics in aging intestinal stem cells, pancreas and liver regeneration, physical principles of organ growth, fibrosis, cancer and the evolution of morphogenesis. By integrating experimental, biophysical, and computational approaches, we aim to build a comprehensive understanding of how tissues form, function, and fail.

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