Mechanical and biochemical cues interacting to shape the pancreas
We investigate how the network of ducts and the branching patterns form during pancreas organogenesis. Using organoids, in vivo…
Contributions of individual cells to an organ community
Using human and mouse organoids, 2D stem cell cultures, mouse genetics, and live imaging, we study how each cell makes a decision to…
Self-organization in organoid models of pancreas development
We have developed 2D and 3D (organoid) models of pancreas development in a dish starting from mouse embryonic cells or engineered from…
Wikipedia page ORCID 0000-0002-1202-5235 Google Scholar
Louis Hewitt Predoc
Organoids serve as an excellent model for investigating the underlying principles of development. However, our current understanding of how cells self-organise into these…
Katharina Hilbig Predoc
Pancreatic development can be followed using 3D cell culture of pancreatic organoids and by interfering with the development of pancreatic progenitor cells. To date,…
Self-organization of cells into organ communities
We study how single cells self-organize as a community to generate an organ, using the pancreas as a model.
To do so, we developed 3D in vitro…
Methodological and technical expertise
Organoids and pluripotent stem cell models Live imaging and quantitative analysis of imaged data Mouse genetics High-content…
Our research encompasses three main axes:
The development of in vitro organoid models that recapitulate aspects of organogenesis in vitro Using this models in a systems biology approach…
