Stembryogenesis
Reconstructing development in a dish to understand how embryos build themselves
Previous and current research
Just like bird flocks and snowflakes, post-implantation embryogenesis…
Fig. 1: Left: live imaging of the development a trunk-like-structure (TLS). Middle: embryo-like architecture is unlocked in TLS (bottom) compared to gastruloids (top). Right: 3D…
Stembryogenesis
Reconstructing development in a dish to understand how embryos build themselves
Previous and current research
Just like bird flocks and snowflakes, post-implantation embryogenesis…
What is metabolic rate and how can we infer it?
Living systems are active and open systems constantly exchange energy and matter with their environment. They function out of equilibrium and require…
Christmas Party 2024 (MPI-CBG, 13.12.)
Lab retreat 2024 in Schlepzig (Spreewald, 30.09.-02.10.)
Joint ATPlab & von Appen lab retreat in Stolpen 2023
Lab photos May 2023
Xmas celebration 2022 - we…
Preprints
not available
Publications
Google Scholar
http://scholar.google.com/citations?user=7KjpSCgAAAAJ&hl=en
Follow @agnestothp
Protein plasticity and evolution
In order for the cell to function properly, proteins must be robust to both changes in their environment and errors made during their synthesis.…
I am a computational biologist interested in the evolution of proteins. My broad background in chemistry, molecular evolution, structural bioinformatics and clinical genetics facilitates the…
Methodological and Technical Expertise
Ex vivo imaging of mammalian tissues Quantitative microscopy Mammalian genetics Primary cell culture
Future Projects and Goals
Our overall goal is to address fundamental questions in developmental biology and evolution; how are tissues shaped and what are the regulators of tissue shape generation…
