Our group aims to understand the restructuring in cell organisation through a combination of high-throughput transgenic techniques and in vivo imaging of cellar components on a systems scale. We are particularly interested in mapping the restructuring of nucleus in parallel with the establishment of cell specific gene expression patterns. We maintain a strong focus on technology development in the field of genome engineering and we collaborate with numerous labs on implementing and refining these techniques. We oversee the Genome Engineering Facility at the MPI-CBG, which provides access to this core technology the the MPI-CBG and the Dresden campus. Our lab is a member of the Center for Regenerative Therapies at the TU Dresden.