Technology Development Groups

Biological membranes efficiently divide space into two compartments. Transport proteins in these membranes enable selective passage of solutes and consequently play a central role in controlling the internal milieu of cells, and strongly affect cellular physiology. The Geertsma lab combines structural and functional studies to obtain a complete mechanistic understanding of transport by solute carriers and to guide our efforts in modulating their activities in complex environmnents as living cells. In parallel and to support these aims, we develop novel enabling technologies for protein research.

The Sarov lab is developing tools that allow the systematic tracking of the protein components that build up the various cell structures. We are particularly interested in how the cell nucleus is restructured during development.