Publications

 

2025

Muhar, M. F., Farnung, J., Cernakova, M., Hofmann, R., Henneberg, L. T., Pfleiderer, M. M., Denoth-Lippuner A., Kalčic F., Nievergelt  A.S., Peters Al-Bayati M., Sidiropoulos N.D., Beier V., Mann M., Jessberger S., Jinek M., Schulman B. A., Bode J. W., Corn, J. E. (2025). C-terminal amides mark proteins for degradation via SCF–FBXO31. Nature, 638(8050), 519-527. DOI: 10.1038/s41586-024-08475-w

2023

Farnung J., Muhar M., Liang J. R., Tolmachova K. A., Benoit,R. M., Corn,J. E., & Bode J. W. (2023). Semisynthetic LC3 probes for autophagy pathways reveal a noncanonical LC3 interacting region motif crucial for the enzymatic activity of human ATG3. ACS Central Science, 9(5), 1025-1034. DOI: 10.1021/acscentsci.3c00009

2021

Diesch J., Le Pannérer M. M., Winkler R., Casquero R., Muhar M., Van Der Garde M., Maher M., Martínez Herráez C., Bech-Serra J. J., Fellner M., Philipp Rathert P., Nigel Brooks N., Zamora L., Gentilella A., de la Torre C., Zuber J., Götze, K. S., Buschbeck M. (2021). Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis. Nature Communications, 12(1), 6060. DOI: 10.1038/s41467-021-26258-z

Endres, T., Solvie, D., Heidelberger, J. B., Andrioletti, V., Baluapuri, A., Ade, C. P., Muhar M., Eilers U., Vos S. M., Cramer P., Zuber J., Beli P., Popov N., Wolf E., Gallant P, Eilers, M. (2021). Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters. Molecular Cell, 81(4), 830-844. DOI: 10.1016/j.molcel.2020.12.035

2020

Liang J. R., Lingeman,E., Luong T., Ahmed S., Muhar M., Nguyen T., Olzman J. A., Corn J. E. (2020). A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-resident UFMylation. Cell, 180(6), 1160-1177. DOI: 10.1016/j.cell.2020.02.017

Thiecke M. J., Wutz G. Muhar M., Tang W., Bevan S., Malysheva V., Stocsits R., Neumann T., Zuber J., Fraser P., Schoenfelder S., Peters J., Spivakov M. (2020). Cohesin-dependent and-independent mechanisms mediate chromosomal contacts between promoters and enhancers. Cell Reports, 32(3). DOI: 10.1016/j.celrep.2020.107929

2019

Neumann T., Herzog V.A., Muhar M., von Haeseler A., Zuber J., Ameres S.L., Rescheneder P. (2019) Quantification of experimentally induced nucleotide conversions in high-throughput sequencing datasets. BMC bioinformatics, 20(1), 258. DOI: 10.1186/s12859-019-2849-7

2018

Muhar M., Ebert A., Neumann T., Umkehrer C., Jude J., Wieshofer C., Rescheneder P., Lipp J. J., Herzog V. A., Reichholf B., Cisneros D. A., Hoffmann T., Schlapansky M. F., Bhat P., Haeseler A. von, Köcher T., Obenauf A. C., Popow J., Ameres S. L., Zuber J., (2018) SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis. Science, 360(6390), 800-805. DOI: 10.1126/science.aao2793

Skucha A., Ebner J., Schmöllerl J., Roth M., Eder T., César-Razquin A., Stukalov A., Vittori S., Muhar M., Lu B., Aichinger M., Jude J., Müller A. C., Győrffy B., Vakoc C. R., Valent P., Bennett K. L., Zuber J., Superti-Furga G., Grebien F. (2018) MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nature Communications, 9(1), 1983. DOI: 10.1038/s41467-018-04329-y

2017

Wutz G., Várnai C., Nagasaka K., Cisneros D. A., Stocsits R. R., Tang W., Schoenfelder S., Jessberger G., Muhar M., Hossain M. J., Walther N., Koch B., Kueblbeck M., Ellenberg J., Zuber J., Fraser P., Peters J., (2017) Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins. EMBO Journal, 36(24), 3573-3599. DOI: 10.15252/embj.201798004

2016

Housden B. E., Muhar M., Gemberling M., Gersbach C. A., Stainier D. Y. R., Seydoux G., Mohr S. E., Zuber J., Perrimon N., (2016) Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. Nature Reviews Genetics, 18(1), 24-40. DOI: 10.1038/nrg.2016.118

2015

Rathert P., Roth M., Neumann T., Muerdter F., Roe J.-S., Muhar M., Deswal S., Cerny-Reiterer S., Peter B., Jude J., Hoffmann T., Boryń Ł. M., Axelsson E., Schweifer N., Tontsch-Grunt U., Dow L. E., Gianni D., Pearson M., Valent P., Stark A., Kraut N., Vakoc C. R., Zuber J., (2015) Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature, 525(7570), 543-547. DOI: 10.1038/nature14898

2013

Shi J., Whyte W. a., Zepeda-Mendoza C. J., Milazzo J. P., Shen C., Roe J.-S., Minder J. L., Mercan F., Wang E., Eckersley-Maslin M. a., Campbell  a. E., Kawaoka S., Shareef S., Zhu Z., Kendall J., Muhar M., Haslinger C., Yu M., Roeder R. G., Wigler M. A., Blobel G. A., Zuber J., Spector D. L., Young R. A., Vakoc C. R., (2013) Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes and Development, 27(24), 2648-2662. DOI: 10.1101/gad.232710.113

Fellmann C., Hoffmann T., Sridhar V., Hopfgartner B., Muhar M., Roth M., Lai D. Y., Barbosa I. A. M., Kwon J. S., Guan Y., Sinha N., Zuber J., (2013) An optimized microRNA backbone for effective single-copy RNAi. Cell Reports, 1704-1713. DOI: 10.1016/j.celrep.2013.11.020

Wienerroither S., Rauch I., Rosebrock F., Jamieson A. M., Bradner J., Muhar M., Zuber J., Müller M., Decker T., (2013) Regulation of NO synthesis, local inflammation and innate immunity to pathogens by BET family proteins. Molecular and Cellular Biology , 34(3), 415-427. DOI: 10.1128/MCB.01353-13