Research Groups

2019

Stefan Münster, Akanksha Jain, Alexander Mietke, Anastasios Pavlopoulos, Stephan W. Grill, Pavel Tomancak
Attachment of the blastoderm to the vitelline envelope affects gastrulation of insects.
Nature, 568(7752) 395-399 (2019)
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Kerstin Klinkert, Nicolas Levernier, Peter Gross, Christian Gentili, Lukas von Tobel, Marie Pierron, Coralie Busso, Sarah Herrman, Stephan W. Grill, Karsten Kruse, Pierre Gönczy
Aurora A depletion reveals centrosome-independent polarization mechanism in C. elegans.
Elife, 8 Art. No. e44552 (2019)

2018

Louise Jawerth, Mahdiye Ijavi, Martine Ruer, Shambaditya Saha, Marcus Jahnel, Anthony A. Hyman, Frank Jülicher, Elisabeth Fischer-Friedrich
Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps.
Phys Rev Lett, 121(25) Art. No. 258101 (2018)
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Peter Gross, K Vijay Kumar, Nathan W. Goehring, Justin S. Bois, Carsten Hoege, Frank Jülicher, Stephan W. Grill
Guiding self-organized pattern formation in cell polarity establishment
Nat Phys, 15(3) 293-300 (2018)
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Sundar Ram Naganathan, Sebastian Fürthauer, Josana Rodriguez, Bruno Thomas Fievet, Frank Jülicher, Julie Ahringer, Carlo Vittorio Cannistraci, Stephan W. Grill
Morphogenetic degeneracies in the actomyosin cortex.
Elife, 7 Art. No. e37677 (2018)
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Lucas Lacasa, Inés P. Mariño, Joaquin Miguez, Vincenzo Nicosia, Édgar Roldán, Ana Lisica, Stephan W. Grill, Jesús Gómez-Gardeñes
Multiplex Decomposition of Non-Markovian Dynamics and the Hidden Layer Reconstruction Problem
Physical Review X, 8(3) Art. No. 031038 (2018)
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Radoslav Aleksandrov, Anton Dotchev, Ina Poser, Dragomir Krastev, Georgi Georgiev, Greta C Panova, Yordan Babukov, Georgi Danovski, Teodora Dyankova, Lars Hubatsch, Aneliya Ivanova, Aleksandar Atemin, Marina N Nedelcheva-Veleva, Susanne Hasse, Mihail Sarov, Frank Buchholz, Anthony Hyman, Stephan W. Grill, Stoyno Stoynov
Protein Dynamics in Complex DNA Lesions.
Mol Cell, 69(6) 1046-1061 (2018)
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Matthäus Mittasch, Peter Gross, Michael Nestler, Anatol W Fritsch, Christiane Iserman, Mrityunjoy Kar, Matthias Munder, Axel Voigt, Simon Alberti, Stephan W. Grill, Moritz Kreysing
Non-invasive perturbations of intracellular flow reveal physical principles of cell organization.
Nat Cell Biol, 20(3) 344-351 (2018)
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Matthäus Mittasch, Peter Gross, Michael Nestler, Anatol W Fritsch, Christiane Iserman, Mrityunjoy Kar, Matthias Munder, Axel Voigt, Simon Alberti, Stephan W. Grill, Moritz Kreysing
How to apply FLUCS in single cells and living embryos
Protocol Exchange, Art. No. doi:10.1038/protex.2017.157 (2018)
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Marcel Naumann, Arun Pal, Anand Goswami, Xenia Lojewski, Julia Japtok, Anne Vehlow, Maximilian Naujock, René Günther, Mengmeng Jin, Nancy Stanslowsky, Peter Reinhardt, Jared Sterneckert, Marie Frickenhaus, Francisco Pan-Montojo, Erik Storkebaum, Ina Poser, Axel Freischmidt, Jochen H Weishaupt, Karlheinz Holzmann, Dirk Troost, Albert C Ludolph, Tobias M Boeckers, Stefan Liebau, Susanne Petri, Nils Cordes, Anthony Hyman, Florian Wegner, Stephan W. Grill, Joachim Weis, Alexander Storch, Andreas Hermann
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.
Nat Commun, 9(1) Art. No. 335 (2018)

2017

Cordula Reuther, Matthäus Mittasch, Sundar Naganathan, Stephan W. Grill, Stefan Diez
Highly-Efficient Guiding of Motile Microtubules on Non-Topographical Motor Patterns.
Nano Lett, 17(9) 5699-5705 (2017)
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Stephan W. Grill
The mechanics of positioning skin follicles.
Science, 357(6353) 750-751 (2017)
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Peter Gross, K Vijay Kumar, Stephan W. Grill
How Active Mechanics and Regulatory Biochemistry Combine to Form Patterns in Development.
Ann Rev Biophys, 46 337-356 (2017)
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Bipul R Acharya, Selwin K Wu, Zi Zhao Lieu, Robert G. Parton, Stephan W. Grill, Alexander D Bershadsky, Guillermo A Gomez, Alpha S Yap
Mammalian Diaphanous 1 Mediates a Pathway for E-cadherin to Stabilize Epithelial Barriers through Junctional Contractility.
Cell Rep, 18(12) 2854-2867 (2017)
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Ana Lisica, Stephan W. Grill
Optical tweezers studies of transcription by eukaryotic RNA polymerases.
Biomol Concepts, 8(1) 1-11 (2017)
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Masatoshi Nishikawa, Sundar Naganathan, Frank Jülicher, Stephan W. Grill
Controlling contractile instabilities in the actomyosin cortex.
Elife, 6 Art. No. e19595 (2017)

2016

Veronika Fitz, Jaeoh Shin, Christoph Ehrlich, Lucas Farnung, Patrick Cramer, Vasily Zaburdaev, Stephan W. Grill
Nucleosomal arrangement affects single-molecule transcription dynamics.
Proc Natl Acad Sci U.S.A., 113(45) 12733-12738 (2016)
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Anne-Cecile Reymann, Fabio Staniscia, Anna Erzberger, Guillaume Salbreux, Stephan W. Grill
Cortical flow aligns actin filaments to form a furrow.
Elife, 5 Art. No. e17807 (2016)
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Shambaditya Saha, Christoph A. Weber, Marco Nousch, Omar Adame-Arana, Carsten Hoege, Marco Y Hein, Erin Osborne-Nishimura, Julia Mahamid, Marcus Jahnel, Louise Jawerth, Andrei Pozniakovski, Christian R. Eckmann, Frank Jülicher, Anthony Hyman
Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism.
Cell, 166(6) 1572-1584 (2016)
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David Murray, Marcus Jahnel, Janelle Lauer, Mario Avellaneda, Nicolas Brouilly, Alice Cezanne, Hernán Morales-Navarrete, Enrico Perini, Charles Ferguson, Andrei N Lupas, Yannis Kalaidzidis, Robert G. Parton, Stephan W. Grill, Marino Zerial
An endosomal tether undergoes an entropic collapse to bring vesicles together.
Nature, 537(7618) 107-111 (2016)
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Édgar Roldán, Ana Lisica, Daniel Sánchez-Taltavull, Stephan W. Grill
Stochastic resetting in backtrack recovery by RNA polymerases.
Phys Rev E, 93(6-1) Art. No. 062411 (2016)
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Arnab Saha, Masatoshi Nishikawa, Martin Behrndt, Carl-Philipp Heisenberg, Frank Jülicher, Stephan W. Grill
Determining Physical Properties of the Cell Cortex.
Biophys J, 110(6) 1421-1429 (2016)
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Ana Lisica, Christoph Engel, Marcus Jahnel, Édgar Roldán, Eric A. Galburt, Patrick Cramer, Stephan W. Grill
Mechanisms of backtrack recovery by RNA polymerases I and II.
Proc Natl Acad Sci U.S.A., 113(11) 2946-2951 (2016)
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Sundar Naganathan, Teije C Middelkoop, Sebastian Fürthauer, Stephan W. Grill
Actomyosin-driven left-right asymmetry: from molecular torques to chiral self organization.
Curr Opin Cell Biol, 38 24-30 (2016)

2015

Veronika Fitz
Chromatin transcription by RNA polymerase II - nucleosomal geometry matters
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2015)
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Avinash Patel, Hyun-Ok Kate Lee, Louise Jawerth, Shovamayee Maharana, Marcus Jahnel, Marco Y Hein, Stoyno Stoynov, Julia Mahamid, Shambaditya Saha, Titus Franzmann, Andrei Pozniakovski, Ina Poser, Nicola Maghelli, Loic Royer, Martin Weigert, Eugene W Myers, Stephan W. Grill, David N. Drechsel, Anthony Hyman, Simon Alberti
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.
Cell, 162(5) 1066-1077 (2015)
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Maria L Begasse, Mark Leaver, Federico Vazquez, Stephan W. Grill, Anthony Hyman
Temperature Dependence of Cell Division Timing Accounts for a Shift in the Thermal Limits of C. elegans and C. briggsae.
Cell Rep, 10(5) 647-653 (2015)

2014

Bi-Chang Chen, Wesley R Legant, Kai Wang, Lin Shao, Daniel E Milkie, Michael W Davidson, Chris Janetopoulos, Xufeng S Wu, John A Hammer, Zhe Liu, Brian P English, Yuko Mimori-Kiyosue, Daniel P Romero, Alex T Ritter, Jennifer Lippincott-Schwartz, Lillian Fritz-Laylin, R Dyche Mullins, Diana M Mitchell, Joshua N Bembenek, Anne-Cecile Reymann, Ralph Böhme, Stephan W. Grill, Jennifer T Wang, Geraldine Seydoux, U Serdar Tulu, Daniel P Kiehart, Eric Betzig
Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution.
Science, 346(6208) Art. No. 1257998 (2014)
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Philipp Khuc Trong, Ernesto M Nicola, Nathan W. Goehring, K Vijay Kumar, Stephan W. Grill
Parameter-space topology of models for cell polarity
New J Phys, 16 Art. No. 065009 (2014)
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K Vijay Kumar, Justin Bois, Frank Jülicher, Stephan W. Grill
Pulsatory Patterns in Active Fluids
Phys Rev Lett, 112 Art. No. 208101 (2014)
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Manuela Weitkunat, Aynur Kaya-Çopur, Stephan W. Grill, Frank Schnorrer
Tension and force-resistant attachment are essential for myofibrillogenesis in Drosophila flight muscle.
Curr Biol, 24(7) 705-716 (2014)
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Evan Heller, K Vijay Kumar, Stephan W. Grill, Elaine Fuchs
Forces generated by cell intercalation tow epidermal sheets in Mammalian tissue morphogenesis.
Dev Cell, 28(6) 617-632 (2014)
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Sundar Naganathan, Sebastian Fürthauer, Masatoshi Nishikawa, Frank Jülicher, Stephan W. Grill
Active torque generation by the actomyosin cell cortex drives left-right symmetry breaking.
Elife, 3 Art. No. e04165 (2014)

2013

Martin Depken, Juan Parrondo, Stephan W. Grill
Intermittent transcription dynamics for the rapid production of long transcripts of high fidelity.
Cell Rep, 5(2) 521-530 (2013)
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Sundar Naganathan
Regulation of mesoscale physical properties of the C.elegans actomyosin cortex
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2013)
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Nathan Goehring, Stephan W. Grill
Cell polarity: mechanochemical patterning.
Trends Cell Biol, 23(2) 72-80 (2013)
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Sebastian Fürthauer, M. Strempel, Stephan W. Grill, Frank Jülicher
Active Chiral Processes in Thin Films
Phys Rev Lett, 110(4) Art. No. 048103 (2013)
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Bruno Thomas Fievet, Josana Rodriguez, Sundar Naganathan, Christine Lee, Eva Zeiser, Takao Ishidate, Masaki Shirayama, Stephan W. Grill, Julie Ahringer
Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy.
Nat Cell Biol, 15(1) 103-112 (2013)

2012

Martin Behrndt, Guillaume Salbreux, Pedro Campinho, Robert Hauschild, Felix Oswald, Julia Roensch, Stephan W. Grill, Carl-Philipp Heisenberg
Forces driving epithelial spreading in zebrafish gastrulation.
Science, 338(6104) 257-260 (2012)
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S Fürthauer, M. Strempel, Stephan W. Grill, Frank Jülicher
Active chiral fluids.
Eur Phys J E Soft Matter, 35(9) Art. No. 89 (2012)
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Sebastian Fürthauer, Maaike Neeft, Stephan W. Grill, Karsten Kruse, Frank Jülicher
The Taylor-Couette motor: spontaneous flows of active polar fluids between two coaxial cylinders
New J Phys, 14(2) Art. No. e023001 (2012)
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Martin Depken, Juan MR Parrondo , Stephan W. Grill
Irregular transcription dynamics for rapid production of high-fidelity transcripts
arXiv, Art. No. 1201.5344 [q-bio.BM] (2012)
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Mirjam Mayer, Guillaume Salbreux, Stephan W. Grill
Biophysics of Cell Developmental Processes: A Lasercutter's Perspective
Comprehensive Biophysics, 7 194-207 (2012)

2011

Louis Leung, Abigail Klopper, Stephan W. Grill, William A Harris, Caren Norden
Apical migration of nuclei during G2 is a prerequisite for all nuclear motion in zebrafish neuroepithelia.
Development, 138(22) 5003-5013 (2011)
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Nathan Goehring, Philipp Khuc Trong, Justin Bois, Debanjan Chowdhury, Ernesto M Nicola, Anthony A. Hyman, Stephan W. Grill
Polarization of PAR Proteins by Advective Triggering of a Pattern-Forming System.
Science, 334(6059) 1137-1141 (2011)
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Stephan W. Grill
Growing up is stressful: biophysical laws of morphogenesis.
Curr Opin Genet Dev, 21(5) 647-652 (2011)
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Matilde Galli, Javier Muñoz, Vincent Portegijs, Mike Boxem, Stephan W. Grill, Albert J R Heck, Sander van den Heuvel
aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.
Nat Cell Biol, 13(9) 1132-1138 (2011)
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Eric A. Galburt, Juan Parrondo, Stephan W. Grill
RNA polymerase pushing.
Biophys Chem, 157(1-3) 43-47 (2011)
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Jonathon Howard, Stephan W. Grill, Justin Bois
Turing's next steps: the mechanochemical basis of morphogenesis.
Nat Rev Mol Cell Biol, 12(6) 400-406 (2011)
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Nathan Goehring, Carsten Hoege, Stephan W. Grill, Anthony A. Hyman
PAR proteins diffuse freely across the anterior-posterior boundary in polarized C. elegans embryos.
J Cell Biol, 193(3) 583-594 (2011)
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Marcus Jahnel, Martin Behrndt, Anita Jannasch, Erik Schäffer, Stephan W. Grill
Measuring the complete force field of an optical trap.
Opt Lett, 36(7) 1260-1262 (2011)
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Nicolas T Chartier, Diana P Salazar Ospina, Laura Benkemoun, Mirjam Mayer, Stephan W. Grill, Amy Shaub Maddox, Jean-Claude Labbé
PAR-4/LKB1 Mobilizes Nonmuscle Myosin through Anillin to Regulate C. elegans Embryonic Polarization and Cytokinesis.
Curr Biol, 21(4) 259-269 (2011)
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Justin Bois, Frank Jülicher, Stephan W. Grill
Pattern formation in active fluids
Phys Rev Lett, 106(2) Art. No. 028103 (2011)

2010

Mirjam Mayer
Mechanics of the C. elegans cell cortex
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2010)
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Stephan W. Grill
Forced to be unequal
Science, 330(6004) 597-598 (2010)
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Nathan W. Goehring, Debanjan Chowdhury, Anthony A. Hyman, Stephan W. Grill
FRAP analysis of membrane-associated proteins: lateral diffusion and membrane-cytoplasmic exchange
Biophys J, 99(8) 2443-2452 (2010)
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Abigail Klopper, Gabriel Krens, Stephan W. Grill, Carl-Philipp Heisenberg
Finite-size corrections to scaling behavior in sorted cell aggregates.
Eur Phys J E Soft Matter, 33(2) 99-103 (2010)
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Mirjam Mayer, Martin Depken, Justin Bois, Frank Jülicher, Stephan W. Grill
Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows.
Nature, 467(7315) 617-621 (2010)
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Abigail Klopper, Justin Bois, Stephan W. Grill
Influence of secondary structure on recovery from pauses during early stages of RNA transcription.
Phys Rev E, 81(3 Pt 1) Art. No. 030904 (2010)

2009

Nicholas Licata, Stephan W. Grill
The first-passage problem for diffusion through a cylindrical pore with sticky walls.
Eur Phys J E Soft Matter, 30(4) 439-447 (2009)
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Eric A. Galburt, Stephan W. Grill, Carlos Bustamante
Single molecule transcription elongation.
Methods, 48(4) 323-332 (2009)
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Martin Depken, Eric A. Galburt, Stephan W. Grill
The origin of short transcriptional pauses.
Biophys J, 96(6) 2189-2193 (2009)

2008

Gohta Goshima, Mirjam Mayer, Nan Zhang, Nico Stuurman, Ronald D Vale
Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle.
J Cell Biol, 181(3) 421-429 (2008)

2007

Eric A. Galburt, Stephan W. Grill, Anna Wiedmann, Lucyna Lubkowska, Jason Choy, Eva Nogales, Mikhail Kashlev, Carlos Bustamante
Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner.
Nature, 446(7137) 820-823 (2007)

2006

Jacques Pecreaux, Jens-Christian Röper, Karsten Kruse, Frank Jülicher, Anthony A. Hyman, Stephan W. Grill, Jonathon Howard
Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators.
Curr Biol, 16(21) 2111-2122 (2006)
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Yongli Zhang, Corey L Smith, Anjanabha Saha, Stephan W. Grill, Shirley Mihardja, Steven B Smith, Bradley R Cairns, Craig L Peterson, Carlos Bustamante
DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC.
Mol Cell, 24(4) 559-568 (2006)

2005

Stephan W. Grill, Karsten Kruse, Frank Jülicher
Theory of mitotic spindle oscillations.
Phys Rev Lett, 94(10) 108104-108104 (2005)

2003

Kelly Colombo, Stephan W. Grill, Randall J Kimple, Francis S Willard, David P Siderovski, Pierre Gönczy
Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.
Science, 300(5627) 1957-1961 (2003)

2001

Stephan W. Grill, Pierre Gönczy, Ernst H K Stelzer, Anthony A. Hyman
Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo.
Nature, 409(6820) 630-633 (2001)