Unraveling biological complexities using super-resolution approaches

Pierre Mangeol joins MPI-CBG and CSBD as ELBE visiting faculty.

Pierre Mangeol © Katrin Boes/MPI-CBG

As a part of the ELBE Visiting Faculty Program of the Center for Systems Biology Dresden (CSBD), Pierre Mangeol arrived at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and CSBD for a six-month visit in the research group of Pavel Tomancak. Pierre is a principal investigator at the Institut de Biologie du Développement de Marseille (IBDM) and holds the position of Assistant Professor at the Aix-Marseille Université in Marseille. His research primarily focuses on exploring the nanoscopic organization of biological systems using super-resolution approaches, automated data analysis, and modeling.

Originally trained as a physicist, Pierre transitioned to the field of quantitative biology during his PhD at the École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI). His postdoctoral research at the University of Amsterdam and IBDM Marseille focused on deciphering the complexities of cellular organization using super-resolution microscopy. Pierre remarks about his research, “The organization of the cell is often hypothesized rather than directly observed. With the rise of super-resolution methods, reaching a novel understanding of cell organization is now possible. Techniques such as DNA-PAINT can achieve a resolution of 5 nanometers, enabling us to uncover the organization of the developing muscle.”

Regarding the ELBE visiting faculty program, he expresses, “The research focus of MPI-CBG and CSBD aligns with my interests: exploring developmental biology through the integration of experimental and theoretical approaches. In this hiatus from teaching, I aim to focus on research and delve into new topics such as utilizing deep learning for data analysis.” During his stay in Dresden, Pierre is looking forward to the exchange of innovative ideas and opportunities to form new collaborations. He holds a particular interest in employing deep learning methodologies for denoising and automating image analysis. Additionally, he aims to develop spatial transcriptomics as a means to further explore morphogenesis in biological systems. He says, “People interested in super-resolution imaging techniques as well as image analysis and modeling should reach out to me.”

The ELBE Visiting Faculty Program at the CSBD continuously offers funded opportunities for researchers working in the area of its mission. During their stay, visiting faculty closely interact with research groups at the CSBD, with labs at the MPI-CBG, and with the Max Planck Institute for the Physics of Complex Systems (MPIPKS).