Preprints
Chi Fung Willis Chow, Soumyadeep Ghosh, Anna Hadarovich, Agnes Toth-Petroczy. SHARK enables homology assessment in unalignable and disordered sequences. bioRxiv…
Former Research Page of Elisabeth Knust, last updated: January 2023
Control of Cell Polarity
Epithelial tissues in multicellular organisms are characterised by a pronounced apico-basal polarity, which is manifested in the asymmetric distribution of organelles and…
Projects
Our research concentrates on the evolutionarily conserved Crumbs (Crb) protein complex. crumbs encodes a large transmembrane protein, with 29 EGF-like repeats and four laminin A…
The Drosophila Crumbs protein complex is required for epithelial cell polarity in the embryo
The Crb protein complex is expressed in all epithelia derived from the ectoderm (epidermis, fore- and…
A Drosophila embryo expressing a GFP-tagged Crumbs protein. Anterior is left, dorsal up [Sven Klose, unpublished].
Cross-section through a Drosophila ommatidum. The apical membrane is subdivided into the most apical part, the rhabdomere (blue), a highly pleated membrane that contains the components of the…
The Drosophila Crumbs protein complex is required for photoreceptor morphogenesis
Photoreceptors develop from epithelial cells by a complex morphogenetic process. During this process and in adult…
Cross-sections through a wild-type and a crb mutant eye kept in constant illumination for 7 days. Most mutant photoreceptor cells have degenerated [From: Johnson et al., 2002]
The Drosophila Crumbs protein complex prevents light-dependent retinal degeneration
crb, sdt and DLin-7 are essential to prevent light-induced retinal degeneration. This phenotype is reminiscent to…
