cryo-electron microscopy and tomography
Since the ‘resolution revolution’ cryo-EM is a technique that can lead to high-resolution structures of proteins and protein complexes. In combination with…
Optical tweezers
To gain insights into the mechanism of nuclear reformation, we construct bottom-up models of membranes and DNA to reconstitute biological systems. By employing advanced tools such…
Mariya Genova
PhD Institut Curie, PSL University MSc and BSc, Heidelberg University
As a biologist, I am intrigued by the mechanisms behind fundamental cellular processes, and I believe that we…
To tackle these questions, we integrate diverse approaches to capture the structure and dynamics of large molecular assemblies.
Our research holds significant relevance as the critical protein…
Mechanisms of nuclear self-assembly
Welcome to the von Appen lab, where we explore the mechanisms of nuclear self-assembly. The nucleus, the largest organelle in human cells, plays a crucial role in…
To tackle these questions, we integrate diverse approaches to capture the structure and dynamics of large molecular assemblies.
Our research holds significant relevance as the critical protein…
Bingkun Li
Junior Specialist, University of California, San Francisco, USA, 2019-2021 BSc Biological Sciences, Sichuan University Chengdu, China, 2015-2019
I am interested in deciphering the…
cryo-CLEM
Light microscopy and electron microscopy have both individual strengths. The unmatched resolution of cryo-electron microscopy comes with the downside of lacking labels. Correlative light…
Integrated Modelling
We use a broad range of complementary techniques to capture the structure and dynamics of large molecular assemblies. Specifically, we focus on the dynamic molecular interaction…
