Allan Distinguished Investigator Award: Visualizing lipid nutrient turnover in human tissue models
Our bodies rely on fats and their molecular cousins, collectively known as lipids. These slippery…
BileCanMet
Cholangiocarcinoma (CCA) has a bleak outlook, with less than 10% of patients surviving five years post-diagnosis due to late detection and limited treatment options. This project seeks to…
Cluster of Excellence – Physics of Life
The Cluster of Excellence “Physics of Life” unites the University and many non-University research institutes in Dresden to elucidate the laws of physics that…
Multiscale MRE: in vivo physics of cancer (FOR5628)
What mechanical changes in soft tissue create an environment that supports cancer growth, and how can these changes be detected early and used to…
Liver Systems Medicine Cancer – LiSyM-Krebs
is an innovative research network that brings together experts from various disciplines to tackle the challenge of liver cancer. Funded by the German…
Organoid development: toward complex organ models
The Huch lab has made ground-breaking contributions to the organoid field, by pioneering the development of organoid models for stomach, liver and…
Mechanism of liver cancer development: when tissue regeneration derails
The Huch group has pioneered the creation of liver cancer organoids from patient tissue. These organoids are tiny, lab-grown…
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state
RNF43/ZNRF3 negatively regulate WNT signalling. Both…
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively…
Long-term culture of genome-stable bipotent stem cells from adult human liver
Despite the enormous replication potential of the human liver, there are currently no culture systems available that…
