Research Groups

2019

Livia Goto-Silva, Marisa P. McShane, Sara Salinas, Yannis Kalaidzidis, Giampietro Schiavo, Marino Zerial
Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome.
Sci Rep, 9(1) Art. No. 2433 (2019)
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Egon Deyaert, Margaux Leemans, Ranjan Kumar Singh, Rodrigo Gallardo, Jan Steyaert, Arjan Kortholt, Janelle Lauer, Wim Versées
Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein.
Biochem J, 476(1) 51-66 (2019)

2018

Martin Weigert, Uwe Schmidt, Tobias Boothe, Andreas Müller, Alexandr Dibrov, Akanksha Jain, Benjamin Wilhelm, Deborah Schmidt, Coleman Broaddus, Sian Culley, Mauricio Rocha-Martins, Fabián Segovia-Miranda, Caren Norden, Ricardo Henriques, Marino Zerial, Michele Solimena, Jochen Rink, Pavel Tomancak, Loic Royer, Florian Jug, Eugene W Myers
Content-aware image restoration: pushing the limits of fluorescence microscopy.
Nat Methods, 15(12) 1090-1097 (2018)
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Hiroo Tanaka, Mitsunobu Imasato, Yuji Yamazaki, Kengo Matsumoto, Koshi Kunimoto, Julien Delpierre, Kirstin Meyer, Marino Zerial, Naho Kitamura, Mitsuhiro Watanabe, Atsushi Tamura, Sachiko Tsukita
Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice.
J Hepatol, 69(6) 1308-1316 (2018)
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Oskar Knittelfelder, Sofia Traikov, Olga Vvedenskaya, Andrea Schuhmann, Sandra Segeletz, Anna Shevchenko, Andrej Shevchenko
Shotgun Lipidomics Combined with Laser Capture Microdissection: A Tool To Analyze Histological Zones in Cryosections of Tissues.
Anal Chem, 90(16) 9868-9878 (2018)
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FoSheng Hsu, Stephanie Spannl, Charles Ferguson, Anthony Hyman, Robert G. Parton, Marino Zerial
Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.
Elife, 7 Art. No. e32282 (2018)

2017

Andreas Müller, Martin Neukam, Anna Ivanova, Anke Sönmez, Carla Münster, Susanne Kretschmar, Yannis Kalaidzidis, Thomas Kurth, Jean-Marc Verbavatz, Michele Solimena
A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags.
Sci Rep, 7 Art. No. 23 (2017)
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Simone Pigolotti, Izaak Neri, Édgar Roldán, Frank Jülicher
Generic Properties of Stochastic Entropy Production.
Phys Rev Lett, 119(14) 140604-140604 (2017)
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Meik Dörpinghaus, Édgar Roldán, Izaak Neri, Heinrich Meyr, Frank Jülicher
An information theoretic analysis of sequential decision-making
In: 2017 IEEE International Symposium on Information Theory (ISIT) : 25-30 June 2017 (2017)(Eds.) Gerhard Kramer, Piscataway, N.J., IEEE (2017), 3050-3054
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Yannis Kalaidzidis
Fluorescence Microscopy Noise Model: Estimation of Poisson Noise Parameters from Snap-Shot Image
In: Proceedings of the 2017 International Conference on Bioinformatics & Computational Biology : BIOCOMP 2017 (2017)(Eds.) Hamid R Arabnia, United States, CSREA Press (2017), 63-66
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J Gray Camp, Keisuke Sekine, Tobias Gerber, Henry Loeffler-Wirth, Hans Binder, Malgorzata Gac, Sabina Kanton, Jorge Kageyama, Georg Damm, Daniel Seehofer, Lenka Belicova, Marc Bickle, Rico Barsacchi, Ryo Okuda, Emi Yoshizawa, Masashi Kimura, Hiroaki Ayabe, Hideki Taniguchi, Takanori Takebe, Barbara Treutlein
Multilineage communication regulates human liver bud development from pluripotency.
Nature, 546(7659) 533-538 (2017)
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Christoph Metzendorf, Anja Zeigerer, Sarah Seifert, Richard Sparla, Bahar Najafi, François Canonne-Hergaux, Marino Zerial, Martina Muckenthaler
Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis.
Sci Rep, 7(1) Art. No. 4023 (2017)
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Kirstin Meyer, Oleksandr Ostrenko, George Bourantas, Hernán Morales-Navarrete, Natalie Porat-Shliom, Fabián Segovia-Miranda, Hidenori Nonaka, Ali Ghaemi, Jean-Marc Verbavatz, Lutz Brusch, Ivo F. Sbalzarini, Yannis Kalaidzidis, Roberto Weigert, Marino Zerial
A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule.
Cell Syst, 4(3) 277-290 (2017)
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Izaak Neri, Édgar Roldán, Frank Jülicher
Statistics of Infima and Stopping Times of Entropy Production and Applications to Active Molecular Processes
Physical Review X, 7(1) Art. No. 011019 (2017)
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Kamil Jastrzębski, Daria Zdżalik-Bielecka, Agnieszka Mamińska, Yannis Kalaidzidis, C Hellberg, Marta Miaczynska
Multiple routes of endocytic internalization of PDGFRβ contribute to PDGF-induced STAT3 signaling.
J Cell Sci, 130(3) 577-589 (2017)
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Anja Zeigerer, Anne Wuttke, Giovanni Marsico, Sarah Seifert, Yannis Kalaidzidis, Marino Zerial
Functional properties of hepatocytes in vitro are correlated with cell polarity maintenance.
Exp Cell Res, 350(1) 242-252 (2017)

2016

Izaak Neri, Fernando Lucas Metz
Eigenvalue Outliers of Non-Hermitian Random Matrices with a Local Tree Structure.
Phys Rev Lett, 117(22) Art. No. 224101 (2016)
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Veronica Astro, Diletta Tonoli, Sara Chiaretti, Sabrina Badanai, Kristyna Sala, Marino Zerial, Ivan de Curtis
Liprin-α1 and ERC1 control cell edge dynamics by promoting focal adhesion turnover.
Sci Rep, 6 Art. No. 33653 (2016)
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David Murray, Marcus Jahnel, Janelle Lauer, Mario Avellaneda, Nicolas Brouilly, Alice Cezanne, Hernán Morales-Navarrete, Enrico Perini, Charles Ferguson, Andrei N Lupas, Yannis Kalaidzidis, Robert G. Parton, Stephan W. Grill, Marino Zerial
An endosomal tether undergoes an entropic collapse to bring vesicles together.
Nature, 537(7618) 107-111 (2016)
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Hassan Mziaut, Bernard Mulligan, Peter Hoboth, Oliver Otto, Anna Ivanova, Maik Herbig, Desiree Schumann, Tobias Hildebrandt, J Dehghany, Anke Sönmez, Carla Münster, M Meyer-Hermann, Jochen Guck, Yannis Kalaidzidis, Michele Solimena
The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.
Mol Metab, 5(8) 656-668 (2016)
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Hernán Morales-Navarrete, Hidenori Nonaka, Fabián Segovia-Miranda, Marino Zerial, Yannis Kalaidzidis
Automatic recognition and characterization of different non-parenchymal cells in liver tissue.
In: 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI) (2016), Piscataway, N.J., IEEE (2016), 536-540
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Hao Yin, Roman L Bogorad, Carmen Barnes, Stephen Walsh, Iris Zhuang, Hidenori Nonaka, Vera M Ruda, Satya Kuchimanchi, Lubomir Nechev, Akin Akinc, Wen Xue, Marino Zerial, Robert Langer, Daniel G Anderson, Victor Koteliansky
RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver.
J Hepatol, 64(4) 899-907 (2016)
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Gregory A O'Sullivan, Peter Jedlicka, Hong-Xing Chen, Heba Kalbouneh, Angelo Ippolito, Thomas Deller, Ralph A Nawrotzki, Jochen Kuhse, Yannis Kalaidzidis, Joachim Kirsch, Stephan W Schwarzacher, Heinrich Betz
Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.
Mol Cell Neurosci, 72 101-113 (2016)
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Kirstin Meyer
An in vivo investigation on the mechanosensory function of the mouse liver
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2016)
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Roberto Villaseñor, Yannis Kalaidzidis, Marino Zerial
Signal processing by the endosomal system.
Curr Opin Cell Biol, 39 53-60 (2016)
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Michael Kuhn, Ivica Letunic, Lars Juhl Jensen, Peer Bork
The SIDER database of drugs and side effects.
Nucleic Acids Res, 44(D1) 1075-1079 (2016)
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Damian Szklarczyk, Alberto Santos, Christian von Mering, Lars Juhl Jensen, Peer Bork, Michael Kuhn
STITCH 5: augmenting protein-chemical interaction networks with tissue and affinity data.
Nucleic Acids Res, 44(D1) 380-384 (2016)
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Jaime Huerta-Cepas, Damian Szklarczyk, Kristoffer Forslund, Helen Cook, Davide Heller, Mathias C Walter, Thomas Rattei, Daniel R Mende, Shinichi Sunagawa, Michael Kuhn, Lars Juhl Jensen, Christian von Mering, Peer Bork
eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences.
Nucleic Acids Res, 44(D1) 286-293 (2016)
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Jon M Carthy, Martin Stöter, Claudia Bellomo, Michael Vanlandewijck, Angelos Heldin, Anita Morén, Dimitris Kardassis, Timothy C Gahman, Andrew K Shiau, Marc Bickle, Marino Zerial, Carl-Henrik Heldin, Aristidis Moustakas
Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.
Sci Rep, 6 Art. No. 29868 (2016)
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Linda Cerofolini, Sabrina Amar, Janelle Lauer, Tommaso Martelli, Marco Fragai, Claudio Luchinat, Gregg B Fields
Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.
Sci Rep, 6 Art. No. 29511 (2016)

2015

Édgar Roldán, Izaak Neri, Meik Dörpinghaus, Heinrich Meyr, Frank Jülicher
Decision Making in the Arrow of Time.
Phys Rev Lett, 115(25) Art. No. 250602 (2015)
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Hernán Morales-Navarrete, Fabián Segovia-Miranda, Piotr Klukowski, Kirstin Meyer, Hidenori Nonaka, Giovanni Marsico, Mikhail Chernykh, Alexander Kalaidzidis, Marino Zerial, Yannis Kalaidzidis
A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture.
Elife, 4 Art. No. e11214 (2015)
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Inna Kalaidzidis, Marta Miaczynska, Marta Brewińska-Olchowik, Anna Hupalowska, Charles Ferguson, Robert G. Parton, Yannis Kalaidzidis, Marino Zerial
APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments.
J Cell Biol, 211(1) 123-144 (2015)
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Jerome Gilleron, Prasath Paramasivam, Anja Zeigerer, William Querbes, Giovanni Marsico, Cordula Andree, Sarah Seifert, Pablo Amaya, Martin Stöter, Victor Koteliansky, Herbert Waldmann, Kevin Fitzgerald, Yannis Kalaidzidis, Akin Akinc, Martin A Maier, Muthiah Manoharan, Marc Bickle, Marino Zerial
Identification of siRNA delivery enhancers by a chemical library screen.
Nucleic Acids Res, 43(16) 7984-8001 (2015)
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J Dehghany, Peter Hoboth, Anna Ivanova, Hassan Mziaut, Andreas Müller, Yannis Kalaidzidis, Michele Solimena, M Meyer-Hermann
A Spatial Model of Insulin-Granule Dynamics in Pancreatic β-Cells.
Traffic, 16(8) 797-813 (2015)
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Jovan Tanevski, Ljupčo Todorovski, Yannis Kalaidzidis, Sašo Džeroski
Domain-specific model selection for structural identification of the Rab5-Rab7 dynamics in endocytosis.
BMC Syst Biol, 9 Art. No. 31 (2015)
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Anja Zeigerer, Roman L Bogorad, Kirti Sharma, Jerome Gilleron, Sarah Seifert, Susanne Sales, Nikolaus Berndt, Sascha Bulik, Giovanni Marsico, Rochelle C J D'Souza, Naharajan Lakshmanaperumal, Kesavan Meganathan, Karthick Natarajan, Agapios Sachinidis, Andreas Dahl, Hermann-Georg Holzhütter, Andrej Shevchenko, Matthias Mann, Victor Koteliansky, Marino Zerial
Regulation of Liver Metabolism by the Endosomal GTPase Rab5.
Cell Rep, 11(6) 884-892 (2015)
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Marisa P. McShane, Tim Friedrichson, Angelika Giner, Felix Meyenhofer, Rico Barsacchi, Marc Bickle, Marino Zerial
A Combination of Screening and Computational Approaches for the Identification of Novel Compounds That Decrease Mast Cell Degranulation.
J Biomol Screen, 20(6) 720-728 (2015)
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Peter Hoboth, Andreas Müller, Anna Ivanova, Hassan Mziaut, J Dehghany, Anke Sönmez, Martina Lachnit, M Meyer-Hermann, Yannis Kalaidzidis, Michele Solimena
Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies.
Proc Natl Acad Sci U.S.A., 112(7) 667-676 (2015)
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Roberto Villaseñor, Hidenori Nonaka, Perla Del Conte-Zerial, Yannis Kalaidzidis, Marino Zerial
Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes.
Elife, 4 Art. No. e06156 (2015)
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Damian Szklarczyk, Andrea Franceschini, Stefan Wyder, Kristoffer Forslund, Davide Heller, Jaime Huerta-Cepas, Milan Simonovic, Alexander Roth, Alberto Santos, Kalliopi P Tsafou, Michael Kuhn, Peer Bork, Lars Juhl Jensen, Christian von Mering
STRING v10: protein-protein interaction networks, integrated over the tree of life.
Nucleic Acids Res, 43(D1) 447-452 (2015)
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Amulya Priya, Inna Kalaidzidis, Yannis Kalaidzidis, David Lambright, Sunando Datta
Molecular insights into rab7-mediated endosomal recruitment of core retromer: deciphering the role of vps26 and vps35.
Traffic, 16(1) 68-84 (2015)
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Yannis Kalaidzidis, Inna Kalaidzidis, Marino Zerial
A Probabilistic Method to Quantify the Colocalization of Markers on Intracellular Vesicular Structures Visualized by Light Microscopy.
In: BAYESIAN INFERENCE AND MAXIMUM ENTROPY METHODS IN SCIENCE AND ENGINEERING (MAXENT 2014) (2015)(Eds.) A. Mohammad-Djafari, F. Barbaresco AIP Conference Proceedings ; 1641, Melville, N.Y., AIP (2015), 580-587

2014

Dirk Drasdo, Johannes Bode, Uta Dahmen, Olaf Dirsch, Steven Dooley, Rolf Gebhardt, Ahmed Ghallab, Patricio Godoy, Dieter Häussinger, Seddik Hammad, Stefan Hoehme, Hermann-Georg Holzhütter, Ursula Klingmüller, Lars Kuepfer, Jens Timmer, Marino Zerial, Jan G Hengstler
The virtual liver: state of the art and future perspectives.
Arch Toxicol, 88(12) 2071-2075 (2014)
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Mihaela Anitei, Ramu Chenna, Cornelia Czupalla, Milan Esner, Sara Christ, Steffi Lenhard, Kerstin Korn, Felix Meyenhofer, Marc Bickle, Marino Zerial, Bernard Hoflack
A high-throughput siRNA screen identifies genes that regulate mannose 6-phosphate receptor trafficking.
J Cell Sci, 127(23) 5079-5092 (2014)
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Norman Gerstner
Endocytic Modulation of Developmental Signaling during Zebrafish Gastrulation
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2014)
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Angela Wandinger-Ness, Marino Zerial
Rab proteins and the compartmentalization of the endosomal system.
Cold Spring Harb Perspect Biol, 6(11) Art. No. a022616 (2014)
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Sandra L Schmid, Alexander Sorkin, Marino Zerial
Endocytosis: Past, Present, and Future.
Cold Spring Harb Perspect Biol, 6(12) Art. No. a022509 (2014)
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Marnix Wieffer, Marisa P. McShane, Marino Zerial
Rab Proteins and the Organization of Organelle Membrane Domains.
In: Ras Superfamily Small G Proteins: Biology and Mechanisms : 2. (Eds.) Alfred Wittinghofer,Cham,Springer International Publishing (2014),17-38 Ch. 2
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Angela Simeone, Giovanni Marsico, Claudio Collinet, Thierry Galvez, Yannis Kalaidzidis, Marino Zerial, Andreas Beyer
Revealing molecular mechanisms by integrating high-dimensional functional screens with protein interaction data.
PLoS Comput Biol, 10(9) Art. No. e1003801 (2014)
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Enrico Perini, Ramona Schaefer, Martin Stöter, Yannis Kalaidzidis, Marino Zerial
Mammalian CORVET Is Required for Fusion and Conversion of Distinct Early Endosome Subpopulations.
Traffic, 15(12) 1366-1389 (2014)
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Milan Esner, Felix Meyenhofer, Michael Kuhn, Melissa Thomas, Yannis Kalaidzidis, Marc Bickle
Development of a Kinetic Assay for Late Endosome Movement.
J Biomol Screen, 19(7) 1070-1078 (2014)
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Varadharajan Sundaramurthy, Rico Barsacchi, Mikhail Chernykh, Martin Stöter, Nadine Tomschke, Marc Bickle, Yannis Kalaidzidis, Marino Zerial
Deducing the mechanism of action of compounds identified in phenotypic screens by integrating their multiparametric profiles with a reference genetic screen.
Nat Protoc, 9(2) 474-490 (2014)
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Roman L Bogorad, Hao Yin, Anja Zeigerer, Hidenori Nonaka, Vera M Ruda, Marino Zerial, Daniel G Anderson, Victor Koteliansky
Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice.
Nat Commun, 5 Art. No. 3869 (2014)

2013

Anna Ivanova, Yannis Kalaidzidis, Ronald Dirkx, Mihail Sarov, Michael Gerlach, Britta Schroth-Diez, Andreas Müller, Yanmei Liu, Cordula Andree, Bernard Mulligan, Carla Münster, Thomas Kurth, Marc Bickle, Stephan Speier, Konstantinos Anastassiadis, Michele Solimena
Age-dependent labeling and imaging of insulin secretory granules.
Diabetes, 62(11) 3687-3696 (2013)
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Jerome Gilleron, William Querbes, Anja Zeigerer, Anna Borodovsky, Giovanni Marsico, Undine Schubert, Kevin Manygoats, Sarah Seifert, Cordula Andree, Martin Stöter, Hila Epstein-Barash, Ligang Zhang, Victor Koteliansky, Kevin Fitzgerald, Eugenio Fava, Marc Bickle, Yannis Kalaidzidis, Akin Akinc, Martin A Maier, Marino Zerial
Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape.
Nat Biotechnol, 31(7) 638-646 (2013)
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A Kyrkou, M Soufi, R Bahtz, Charles Ferguson, M Bai, Robert G. Parton, Ingrid Hoffmann, Marino Zerial, Theodore Fotsis, Carol Murphy
The RhoD to centrosomal duplication.
Small GTPases, 4(2) 116-122 (2013)
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A Kyrkou, M Soufi, R Bahtz, Charles Ferguson, M Bai, Robert G. Parton, I Hoffmann, Marino Zerial, Theodore Fotsis, C Murphy
RhoD participates in the regulation of cell-cycle progression and centrosome duplication.
Oncogene, 32(14) 1831-1842 (2013)
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Enrico Perini
In vitro reconstitution of the molecular mechanisms of vesicle tethering and membrane fusion
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2013)
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Varadharajan Sundaramurthy, Rico Barsacchi, Nikolay Samusik, Giovanni Marsico, Jerome Gilleron, Inna Kalaidzidis, Felix Meyenhofer, Marc Bickle, Yannis Kalaidzidis, Marino Zerial
Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing.
Cell Host Microbe, 13(2) 129-142 (2013)

2012

Jerome Gilleron, Anja Zeigerer, Giovanni Marsico, Thierry Galvez, Marino Zerial
[Key role of Rab5: from endosome biogenesis to liver metabolism].
Med Sci (Paris), 28(12) 1041-1044 (2012)
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Thierry Galvez, Jerome Gilleron, Marino Zerial, Gregory A O'Sullivan
SnapShot: Mammalian Rab proteins in endocytic trafficking.
Cell, 151(1) Art. No. 234-234.e2. (2012)
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Lionel Foret, Jonathan E Dawson, Roberto Villaseñor, Claudio Collinet, Andreas Deutsch, Lutz Brusch, Marino Zerial, Yannis Kalaidzidis, Frank Jülicher
A General Theoretical Framework to Infer Endosomal Network Dynamics from Quantitative Image Analysis.
Curr Biol, 22(15) 1381-1390 (2012)
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David B Thompson, Roberto Villaseñor, Brent M Dorr, Marino Zerial, David R Liu
Cellular uptake mechanisms and endosomal trafficking of supercharged proteins.
Chem Biol, 19(7) 831-843 (2012)
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Simone Fietz, Robert Lachmann, Holger Brandl, Martin Kircher, Nikolay Samusik, Roland Schröder, Naharajan Lakshmanaperumal, Ian Henry, Johannes Vogt, Axel Riehn, Wolfgang Distler, Robert Nitsch, Wolfgang Enard, Svante Pääbo, Wieland B. Huttner
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal.
Proc Natl Acad Sci U.S.A., 109(29) 11836-11841 (2012)
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C Schmees, Roberto Villaseñor, W Zheng, H Ma, Marino Zerial, Carl-Henrik Heldin, C Hellberg
Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V.
Mol Biol Cell, 23(13) 2571-2582 (2012)
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Julia Franziska Winter, Sebastian Höpfner, Kerstin Korn, Benjamin Farnung, Charles R. Bradshaw, Giovanni Marsico, Michael Volkmer, Bianca Habermann, Marino Zerial
Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity.
Nat Cell Biol, 14(7) 666-676 (2012)
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Rico Barsacchi, Varadharajan Sundaramurthy, Kees Korbee, Jacques Neefjes, Tom H. M. Ottenhoff, Tiziana Scanu, Marino Zerial
Manipulating the Fight Between Human Host Cells and Intracellular Pathogens
In: Systems Microbiology: Current Topics and Applications. (Eds.) Brian D. Robertson, Brendan W. Wren,Norfolk,Caister Acad. Press (2012),77-94 Ch. 5
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Anja Zeigerer, Jerome Gilleron, Roman L Bogorad, Giovanni Marsico, Hidenori Nonaka, Sarah Seifert, Hila Epstein-Barash, Satya Kuchimanchi, Chang Geng Peng, Vera M Ruda, Perla Del Conte-Zerial, Jan G Hengstler, Yannis Kalaidzidis, Victor Koteliansky, Marino Zerial
Rab5 is necessary for the biogenesis of the endolysosomal system in vivo.
Nature, 485(7399) 465-470 (2012)
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Matthias Stein, Manohar Pilli, Sabine Bernauer, Bianca Habermann, Marino Zerial, Rebecca C Wade
The interaction properties of the human Rab GTPase family--comparative analysis reveals determinants of molecular binding selectivity.
PLoS ONE, 7(4) Art. No. e34870 (2012)
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Francisco Pan-Montojo, Mathias Schwarz, Christian Winkler, Mike Arnhold, Gregory A O'Sullivan, Arun Pal, Jonas Said, Giovanni Marsico, Jean-Marc Verbavatz, Margarita Rodrigo-Angulo, Gabriele Gille, Richard Funk, Heinz Reichmann
Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice.
Sci Rep, 2 Art. No. 898 (2012)

2011

Anton A Poznyakovskiy, Thomas Zahnert, Yannis Kalaidzidis, Nikoloz Lazurashvili, Rolf Schmidt, Hans-Jürgen Hardtke, Björn Fischer, Yury M Yarin
A segmentation method to obtain a complete geometry model of the hearing organ.
Hear Res, 282(1-2) 25-34 (2011)
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Asifa Akhtar, Elaine Fuchs, Timothy J. Mitchison, Reuben J Shaw, Daniel St Johnston, Andreas Strasser, Susan Taylor, Claire E. Walczak, Marino Zerial
A decade of molecular cell biology: achievements and challenges.
Nat Rev Mol Cell Biol, 12(10) 669-674 (2011)
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Anna Urbanska, Lukasz Sadowski, Yannis Kalaidzidis, Marta Miaczynska
Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment
Traffic, 12(9) 1227-1241 (2011)
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Iwona Pilecka, Lukasz Sadowski, Yannis Kalaidzidis, Marta Miaczynska
Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment
Exp Cell Res, 317(8) 1093-1107 (2011)
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Giovanni Marsico
Analysis of the interplay between endocytosis and cell morphology through the development of computational methods
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2011)
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Danming Tang, Yi Xiang, Stefano de Renzis, Jochen Rink, Gen Zheng, Marino Zerial, Yanzhuang Wang
The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle.
Nat Commun, 2 Art. No. 501 (2011)

2010

Akhila Chandrashaker
Systems analysis of early endosome motility through identification of molecular motors
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2010)
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Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K Narayanannair Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G Rajeev, William L Cantley, J Robert Dorkin, James S Butler, Liuliang Qin, Timothy Racie, Andrew Sprague, Eugenio Fava, Anja Zeigerer, Michael J Hope, Marino Zerial, Dinah W Y Sah, Kevin Fitzgerald, Mark A Tracy, Muthiah Manoharan, Victor Koteliansky, Antonin de Fougerolles, Martin A Maier
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.
Mol Ther, 18(7) 1357-1364 (2010)
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Giovanna Mottola, Anne-Kathrin Classen, Marcos González-Gaitán, Suzanne Eaton, Marino Zerial
A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity.
Development, 137(14) 2353-2364 (2010)
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Hesso Farhan, Markus W Wendeler, Sandra Mitrovic, Eugenio Fava, Yael Silberberg, Roded Sharan, Marino Zerial, Hans-Peter Hauri
MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.
J Cell Biol, 189(6) 997-1011 (2010)
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Dmitry Poteryaev, Sunando Datta, Karin Ackema, Marino Zerial, Anne Spang
Identification of the switch in early-to-late endosome transition.
Cell, 141(3) 497-508 (2010)
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Claudio Collinet, Martin Stöter, Charles R. Bradshaw, Nikolay Samusik, Jochen Rink, Denise Kenski, Bianca Habermann, Frank Buchholz, Robert Henschel, Matthias S Mueller, Wolfgang E Nagel, Eugenio Fava, Yannis Kalaidzidis, Marino Zerial
Systems survey of endocytosis by multiparametric image analysis.
Nature, 464(7286) 243-249 (2010)
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Livia Goto-Silva
Characterization of APPL signalling endosomes in neurons
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2010)

2009

Dirk Helbing, Andreas Deutsch, Stefan Diez, Karsten Peters, Yannis Kalaidzidis, Kathrin Padberg-Gehle, Stefan Lämmer, Anders Johansson, Georg Breier, Frank Schulze, Marino Zerial
Biologistics and the struggle for efficiency: concepts and perspectives
Adv complex systems, 12(6) 533-548 (2009)
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Takeshi Ohya, Marta Miaczynska, Uenal Coskun, Barbara Lommer, Anja Runge, David N. Drechsel, Yannis Kalaidzidis, Marino Zerial
Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.
Nature, 459(7250) 1091-1097 (2009)
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Jesper B Bramsen, Maria B Laursen, Anne F Nielsen, Thomas B Hansen, Claus Bus, Niels Langkjaer, B Ravindra Babu, Torben Højland, Mikhail Abramov, Arthur Van Aerschot, Dalibor Odadzic, Romualdas Smicius, Jens Haas, Cordula Andree, Jharna Barman, Malgorzata Wenska, Puneet Srivastava, Chuanzheng Zhou, Dmytro Honcharenko, Simone Hess, Elke Müller, Georgii V Bobkov, Sergey N Mikhailov, Eugenio Fava, Thomas F Meyer, Jyoti Chattopadhyaya, Marino Zerial, Joachim W Engels, Piet Herdewijn, Jesper Wengel, Jørgen Kjems
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Nucleic Acids Res, 37(9) 2867-2881 (2009)
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Claudio Collinet
System survey of endocytosis by functional genomics and quantitative multi-parametric image analysis
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2009)
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Yonathan Lissanu Deribe, Philipp Wild, Akhila Chandrashaker, Jasna Curak, Mario Schmidt, Yannis Kalaidzidis, Natasa Milutinovic, Irina Kratchmarova, Lukas Buerkle, Michael J Fetchko, Philipp Schmidt, Saranya Kittanakom, Kevin R Brown, Igor Jurisica, Blagoy Blagoev, Marino Zerial, Igor Stagljar, Ivan Dikic
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.
Sci Signal, 2(102) Art. No. ra84 (2009)
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Yannis Kalaidzidis
Multiple objects tracking in fluorescence microscopy.
J Math Biol, 58(1-2) 57-80 (2009)
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Charles R. Bradshaw
Improving the analysis of genome-wide screens through the detection of weakly conserved domains
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2009)

2008

Anton A Poznyakovskiy, Thomas Zahnert, Yannis Kalaidzidis, Rolf Schmidt, Björn Fischer, Johannes Baumgart, Yury M Yarin
The creation of geometric three-dimensional models of the inner ear based on micro computer tomography data.
Hear Res, 243(1-2) 95-104 (2008)
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Marisa P. McShane, Marino Zerial
Survival of the weakest: signaling aided by endosomes.
J Cell Biol, 182(5) 823-825 (2008)
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Annette Schenck, Livia Goto-Silva, Claudio Collinet, Muriel Rhinn, Angelika Giner, Bianca Habermann, Michael Brand, Marino Zerial
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development.
Cell, 133(3) 486-497 (2008)
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Arun Pal, Fedor F. Severin, Sebastian Höpfner, Marino Zerial
Regulation of endosome dynamics by Rab5 and Huntingtin-HAP40 effector complex in physiological versus pathological conditions
In: Small GTPases in disease. (Eds.) William E. Balch Methods in enzymology ; 438.,Amsterdam, Netherlands,Elsevier (2008),239-257 Ch. 17
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Perla Del Conte-Zerial, Lutz Brusch, Jochen Rink, Claudio Collinet, Yannis Kalaidzidis, Marino Zerial, Andreas Deutsch
Membrane identity and GTPase cascades regulated by toggle and cut-out switches.
Mol Syst Biol, 4 206-206 (2008)
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Julia Franziska Winter
Genome-wide analysis of membrane trafficking in polarised epithelial cells in the C. elegans intestine
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2008)

2007

Yannis Kalaidzidis
Intracellular objects tracking.
Eur J Cell Biol, 86(9) 569-578 (2007)
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Torben Lessmann, Michele G Leuenberger, Sascha Menninger, Meritxell Lopez-Canet, Oliver Müller, Stefan Hümmer, Jenny Bormann, Kerstin Korn, Eugenio Fava, Marino Zerial, Thomas U Mayer, Herbert Waldmann
Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase.
Chem Biol, 14(4) 443-451 (2007)
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Anna Kicheva, Periklis Pantazis, Tobias Bollenbach, Yannis Kalaidzidis, Thomas Bittig, Frank Jülicher, Marcos González-Gaitán
Kinetics of morphogen gradient formation.
Science, 315(5811) 521-525 (2007)

2006

Arun Pal, Fedor F. Severin, Barbara Lommer, Anna Shevchenko, Marino Zerial
Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease.
J Cell Biol, 172(4) 605-618 (2006)

2005

Sally Martin, Kim Driessen, Susan J. Nixon, Marino Zerial, Robert G. Parton
Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism.
J Biol Chem, 280(51) 42325-42335 (2005)
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Jochen Rink, Eric Ghigo, Yannis Kalaidzidis, Marino Zerial
Rab conversion as a mechanism of progression from early to late endosomes.
Cell, 122(5) 735-749 (2005)
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Gaëtane Macé, Marta Miaczynska, Marino Zerial, Angel R Nebreda
Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis.
EMBO J, 24(18) 3235-3246 (2005)
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Hye-Won Shin, Mitsuko Hayashi, Savvas Christoforidis, Sandra Lacas-Gervais, Sebastian Hoepfner, Markus R Wenk, Jan Modregger, Sandrine Uttenweiler-Joseph, Matthias Wilm, Arne Nystuen, Wayne N Frankel, Michele Solimena, Pietro De Camilli, Marino Zerial
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway.
J Cell Biol, 170(4) 607-618 (2005)
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Lucas Pelkmans, Marino Zerial
Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae.
Nature, 436(7047) 128-133 (2005)
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Lucas Pelkmans, Eugenio Fava, Hannes Grabner, Michael Hannus, Bianca Habermann, Eberhard Krausz, Marino Zerial
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis.
Nature, 436(7047) 78-86 (2005)
---
Sebastian Höpfner
Modulation of Cargo Transport and Sorting through Endosome Motility and Positioning
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2005)
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Sebastian Hoepfner, Fedor F. Severin, Alicia Cabezas, Bianca Habermann, Anja Runge, David J. Gillooly, Harald Stenmark, Marino Zerial
Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B.
Cell, 121(3) 437-450 (2005)
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Eberhard Krausz, Lucas Pelkmans, Eugenio Fava, Michael Hannus, Claudia Möbius, Kerstin Korn, Francoise Halley, Annett Lohmann, Hannes Grabner, Marino Zerial
Genomweite funktionelle Analyse des Kinoms mittels RNA-Interfernz
BIOspektrum, 11(SH) 518-520 (2005)

2004

Carsten Schnatwinkel, Savvas Christoforidis, Margaret R Lindsay, Sandrine Uttenweiler-Joseph, Matthias Wilm, Robert G. Parton, Marino Zerial
The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.
PLoS Biol, 2(9) 261-261 (2004)
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Lucas Pelkmans, Thomas Bürli, Marino Zerial, Ari Helenius
Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic.
Cell, 118(6) 767-780 (2004)
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Marta Miaczynska, Lucas Pelkmans, Marino Zerial
Not just a sink: endosomes in control of signal transduction.
Curr Opin Cell Biol, 16(4) 400-406 (2004)
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Marta Miaczynska, Savvas Christoforidis, Angelika Giner, Anna Shevchenko, Sandrine Uttenweiler-Joseph, Bianca Habermann, Matthias Wilm, Robert G. Parton, Marino Zerial
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.
Cell, 116(3) 445-456 (2004)

2003

Stéphane Gasman, Yannis Kalaidzidis, Marino Zerial
RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.
Nat Cell Biol, 5(3) 195-204 (2003)
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Rafael Mattera, Cecilia N Arighi, Robert Lodge, Marino Zerial, Juan S Bonifacino
Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex.
EMBO J, 22(1) 78-88 (2003)

2002

James T Murray, Christina Panaretou, Harald Stenmark, Marta Miaczynska, Jonathan M Backer
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome.
Traffic, 3(6) 416-427 (2002)
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Ekaterini Panopoulou, David J. Gillooly, Jeffrey L Wrana, Marino Zerial, Harald Stenmark, Carol Murphy, Theodore Fotsis
Early endosomal regulation of Smad-dependent signaling in endothelial cells.
J Biol Chem, 277(20) 18046-18052 (2002)
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Stefano de Renzis, Birte Sönnichsen, Marino Zerial
Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes.
Nat Cell Biol, 4(2) 124-133 (2002)
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Marta Miaczynska, Marino Zerial
Mosaic organization of the endocytic pathway.
Exp Cell Res, 272(1) 8-14 (2002)

2001

Roger Lippé, Marta Miaczynska, Vladimir Rybin, Anja Runge, Marino Zerial
Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex.
Mol Biol Cell, 12(7) 2219-2228 (2001)
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Heike Esters, Kirill Alexandrov, Andrei Iakovenko, Tania Ivanova, Nicolas Thomä, Vladimir Rybin, Marino Zerial, Axel J. Scheidig, Roger S. Goody
Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins.
J Mol Biol, 310(1) 141-156 (2001)
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Carol Murphy, Rainer Saffrich, Jean-Christophe Olivo-Marin, Angelika Giner, Wilhelm Ansorge, Theodore Fotsis, Marino Zerial
Dual function of rhoD in vesicular movement and cell motility.
Eur J Cell Biol, 80(6) 391-398 (2001)
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Sandrine Uttenweiler-Joseph, Gitte Neubauer, Savvas Christoforidis, Marino Zerial, Matthias Wilm
Automated de novo sequencing of proteins using the differential scanning technique.
Proteomics, 1(5) 668-682 (2001)
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Tom Van de Putte, An Zwijsen, Olivier Lonnoy, Vladimir Rybin, Miranda Cozijnsen, Annick Francis, Veerle Baekelandt, Christine A. Kozak, Marino Zerial, Danny Huylebroeck
Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development.
Mech Dev, 102(1-2) 33-44 (2001)
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Marino Zerial, Heidi M. McBride
Rab proteins as membrane organizers.
Nat Rev Mol Cell Biol, 2(2) 107-117 (2001)
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Savvas Christoforidis, Marino Zerial
Purification of EEA1 from bovine brain cytosol using Rab5 affinity chromatography and activity assays
In: GTPases involved in vesicular traffic. (Eds.) William E. Balch Methods in enzymology ; 329.,Amsterdam, Netherlands,Academic Press (2001),120-132 Ch. 14
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Harald Stenmark, Marino Zerial
Molecular mechanisms of membrane fusion in the endocytic pathway
In: Endocytosis. (Eds.) Mark Marsh Frontiers in molecular biology ; 36.,Oxford, UK,Oxford University Press (2001),94-110 Ch. 5
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Erik Nielsen, Fedor F. Severin, Anthony A. Hyman, Marino Zerial
In vitro reconstitution of endosome motility along microtubules
In: Kinesin protocols. (Eds.) Isabelle Vernos Methods in molecular biology ; 164.,Totowa, USA,Humana Press (2001),133-146 Ch. 12
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Roger Lippé, Hisanori Horiuchi, Anja Runge, Marino Zerial
Expression, purification, and characterization of Rab5 effector complex, rabaptin-5/rabex-5
In: GTPases involved in vesicular traffic. (Eds.) William E. Balch Methods in enzymology ; 329.,Amsterdam, Netherlands,Elsevier (2001),132-145

2000

Letizia Lanzetti, Vladimir Rybin, Maria Grazia Malabarba, Savvas Christoforidis, Giorgio Scita, Marino Zerial, Pier Paolo Di Fiore
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.
Nature, 408(6810) 374-377 (2000)
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Erik Nielsen, Savvas Christoforidis, Sandrine Uttenweiler-Joseph, Marta Miaczynska, Frederique Dewitte, Matthias Wilm, Bernard Hoflack, Marino Zerial
Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain.
J Cell Biol, 151(3) 601-612 (2000)
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Sanna Lehtonen, Ari Ora, Vesa M Olkkonen, Lin Geng, Marino Zerial, Stefan Somlo, Eero Lehtonen
In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2.
J Biol Chem, 275(42) 32888-32893 (2000)
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Birte Sönnichsen, Stefano de Renzis, Erik Nielsen, Jens Rietdorf, Marino Zerial
Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11.
J Cell Biol, 149(4) 901-914 (2000)
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Savvas Christoforidis, Marino Zerial
Purification and identification of novel Rab effectors using affinity chromatography.
Methods, 20(4) 403-410 (2000)
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Mariantonietta Rubino, Marta Miaczynska, Roger Lippé, Marino Zerial
Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes.
J Biol Chem, 275(6) 3745-3748 (2000)

1999

Savvas Christoforidis, Marta Miaczynska, Keith Ashman, Matthias Wilm, Liyun Zhao, Shu-Chin Yip, Michael D. Waterfield, Jonathan M Backer, Marino Zerial
Phosphatidylinositol-3-OH kinases are Rab5 effectors.
Nat Cell Biol, 1(4) 249-252 (1999)
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Heidi M. McBride, Vladimir Rybin, Carol Murphy, Angelika Giner, Rohan Teasdale, Marino Zerial
Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13.
Cell, 98(3) 377-386 (1999)
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Jon Mulholland, James Konopka, Birgit Singer-Kruger, Marino Zerial, David Botstein
Visualization of receptor-mediated endocytosis in yeast.
Mol Biol Cell, 10(3) 799-817 (1999)
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Savvas Christoforidis, Heidi M. McBride, Robert D. Burgoyne, Marino Zerial
The Rab5 effector EEA1 is a core component of endosome docking.
Nature, 397(6720) 621-625 (1999)

1998

Sanna Lehtonen, Vesa M Olkkonen, Mark Stapleton, Marino Zerial, Eero Lehtonen
HMG-17, a chromosomal non-histone protein, shows developmental regulation during organogenesis.
Int J Dev Biol, 42(6) 775-782 (1998)
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Anne Simonsen, Roger Lippé, Savvas Christoforidis, Jean-Michel Gaullier, Andreas Brech, Judy Callaghan, Ban-Hock Toh, Carol Murphy, Marino Zerial, Harald Stenmark
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion.
Nature, 394(6692) 494-498 (1998)
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Helene Gournier, Harald Stenmark, Vladimir Rybin, Roger Lippé, Marino Zerial
Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion.
EMBO J, 17(7) 1930-1940 (1998)
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Gaetano Vitale, Vladimir Rybin, Savvas Christoforidis, Per-Ove Thornqvist, Mary McCaffrey, Harald Stenmark, Marino Zerial
Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5.
EMBO J, 17(7) 1941-1951 (1998)
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Paola Zacchi, Harald Stenmark, Robert G. Parton, Donata Orioli, Filip Lim, Angelika Giner, Ira Mellman, Marino Zerial, Carol Murphy
Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells.
J Cell Biol, 140(5) 1039-1053 (1998)
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Harald Stenmark, Marino Zerial
Transient Expression Using the T7 RNA Polymerase Recombinant Vaccinia Virus System
In: Cell Biology: A Laboratory Handbook, 2nd Edition, Vol. 4. (Eds.) Julio E. Celis,Amsterdam, Netherlands,Academic Press (1998),201-203 Ch. 14
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Harald Stenmark, Marino Zerial
Stock Preparation of Recombinant Vaccinia Virus
In: Cell Biology: A Laboratory Handbook, 2nd Edition, Vol. 1. (Eds.) Julio E. Celis,Amsterdam, Netherlands,Academic Press (1998),540-543
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Marino Zerial
Membranes and sorting
Curr Opin Cell Biol, 10 475-476 (1998)

1997

Harald Stenmark, Marino Zerial
Lipofection
In: Cell Biology: A Laboratory Handbook, 2nd Edition, Vol. 4. (Eds.) Julio E. Celis,Amsterdam, Netherlands,Academic Press (1997),141-144 Ch. 13