Research Groups
- Alexander von Appen
- Jan Brugués
- Dye / Eaton
- Anne Grapin-Botton
- Stephan Grill
- Pierre Haas
- Alf Honigmann
- Meritxell Huch
- Wieland Huttner
- Anthony Hyman
- Florian Jug
- Elisabeth Knust
- Moritz Kreysing
- Rita Mateus
- Carl Modes
- Gene Myers
- André Nadler
- Gaia Pigino
- Jonathan Rodenfels
- Ivo Sbalzarini
- Andrej Shevchenko
- Jacqueline Tabler
- Dora Tang
- Pavel Tomancak
- Agnes Toth-Petroczy
- Jesse Veenvliet
- Christoph Zechner
- Marino Zerial
Publications
* joined first author
# joined corresponding author
2021
Thomas Quail, Stefan Golfier, Maria Elsner, Keisuke Ishihara, Vasanthanarayan Murugesan, Roman Renger, Frank Jülicher#, Jan Brugués#
Force generation by protein-DNA co-condensation.
Nat Phys, 17(9) 1007-1012 (2021)
Open Access DOI
Force generation by protein-DNA co-condensation.
Nat Phys, 17(9) 1007-1012 (2021)
Open Access DOI
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Chang-Yu Chang✳︎, Jean C C Vila✳︎, Madeline Bender, Richard Li, Madeleine C Mankowski, Molly Bassette, Julia Borden, Stefan Golfier, Paul Gerald L Sanchez, Rachel Waymack, Xinwen Zhu, Juan Diaz-Colunga, Sylvie Estrela, Maria Rebolleda-Gomez, Alvaro Sanchez
Engineering complex communities by directed evolution.
Nat Ecol Evol, 5(7) 1011-1023 (2021)
DOI
Chang-Yu Chang✳︎, Jean C C Vila✳︎, Madeline Bender, Richard Li, Madeleine C Mankowski, Molly Bassette, Julia Borden, Stefan Golfier, Paul Gerald L Sanchez, Rachel Waymack, Xinwen Zhu, Juan Diaz-Colunga, Sylvie Estrela, Maria Rebolleda-Gomez, Alvaro Sanchez
Engineering complex communities by directed evolution.
Nat Ecol Evol, 5(7) 1011-1023 (2021)
DOI
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Benjamin Dalton✳︎, David Oriola✳︎, Franziska Decker✳︎, Frank Jülicher, Jan Brugués
A gelation transition enables the self-organization of bipolar metaphase spindles.
bioRxiv, Art. No. https://doi.org/10.1101/2021.01.15.426844 (2021)
Open Access DOI
Benjamin Dalton✳︎, David Oriola✳︎, Franziska Decker✳︎, Frank Jülicher, Jan Brugués
A gelation transition enables the self-organization of bipolar metaphase spindles.
bioRxiv, Art. No. https://doi.org/10.1101/2021.01.15.426844 (2021)
Open Access DOI
---
Keisuke Ishihara, Franziska Decker, Paulo Caldas, James F. Pelletier, Martin Loose, Jan Brugués, Timothy J. Mitchison
Spatial Variation of Microtubule Depolymerization in Large Asters.
Mol Biol Cell, 32(9) 869-879 (2021)
DOI
Keisuke Ishihara, Franziska Decker, Paulo Caldas, James F. Pelletier, Martin Loose, Jan Brugués, Timothy J. Mitchison
Spatial Variation of Microtubule Depolymerization in Large Asters.
Mol Biol Cell, 32(9) 869-879 (2021)
DOI
2020
Elisa Maria Rieckhoff, Frederic Berndt, Maria Elsner, Stefan Golfier, Franziska Decker, Keisuke Ishihara, Jan Brugués
Spindle Scaling Is Governed by Cell Boundary Regulation of Microtubule Nucleation.
Curr Biol, 30(24) 4973-4983 (2020)
Open Access DOI
Spindle Scaling Is Governed by Cell Boundary Regulation of Microtubule Nucleation.
Curr Biol, 30(24) 4973-4983 (2020)
Open Access DOI
---
Patrick M McCall, Kyoohyun Kim, Anatol W Fritsch, Juan M Iglesias-Artola, Louise Jawerth, Jie Wang, Martine Ruer, Jan Peychl, Andrey Poznyakovskiy, Jochen Guck, Simon Alberti, Anthony A. Hyman, Jan Brugues
Quantitative phase microscopy enables precise and efficient determination of biomolecular condensate composition.
bioRxiv, Art. No. https://doi.org/10.1101/2020.10.25.352823 (2020)
Open Access DOI
Patrick M McCall, Kyoohyun Kim, Anatol W Fritsch, Juan M Iglesias-Artola, Louise Jawerth, Jie Wang, Martine Ruer, Jan Peychl, Andrey Poznyakovskiy, Jochen Guck, Simon Alberti, Anthony A. Hyman, Jan Brugues
Quantitative phase microscopy enables precise and efficient determination of biomolecular condensate composition.
bioRxiv, Art. No. https://doi.org/10.1101/2020.10.25.352823 (2020)
Open Access DOI
---
Thomas Quail, Stefan Golfier, Maria Elsner, Keisuke Ishihara, Frank Jülicher, Jan Brugués
Capillary forces drive pioneer transcription factor-mediated DNA condensation.
bioRxiv, Art. No. https://doi.org/10.1101/2020.09.17.302299 (2020)
Open Access DOI
Thomas Quail, Stefan Golfier, Maria Elsner, Keisuke Ishihara, Frank Jülicher, Jan Brugués
Capillary forces drive pioneer transcription factor-mediated DNA condensation.
bioRxiv, Art. No. https://doi.org/10.1101/2020.09.17.302299 (2020)
Open Access DOI
---
Keisuke Ishihara#, Ashish B George, Ryan Cornelius, Kirill S Korolev#
Traveling fronts in self-replicating persistent random walks with multiple internal states.
New J Phys, 22(8) Art. No. 083034 (2020)
Open Access DOI
Keisuke Ishihara#, Ashish B George, Ryan Cornelius, Kirill S Korolev#
Traveling fronts in self-replicating persistent random walks with multiple internal states.
New J Phys, 22(8) Art. No. 083034 (2020)
Open Access DOI
---
David Oriola, Frank Jülicher#, Jan Brugués#
Active forces shape the metaphase spindle through a mechanical instability.
Proc Natl Acad Sci U.S.A., 117(28) 16154-16159 (2020)
DOI
David Oriola, Frank Jülicher#, Jan Brugués#
Active forces shape the metaphase spindle through a mechanical instability.
Proc Natl Acad Sci U.S.A., 117(28) 16154-16159 (2020)
DOI
---
Keisuke Ishihara, Franziska Decker, Paulo Caldas, James F. Pelletier, Martin Loose, Jan Brugués, Timothy J. Mitchison
Spatial Variation of Microtubule Depolymerization in Large Asters Suggests Regulation by MAP Depletion.
bioRxiv, Art. No. https://doi.org/10.1101/2020.06.26.172783 (2020)
Open Access DOI
Keisuke Ishihara, Franziska Decker, Paulo Caldas, James F. Pelletier, Martin Loose, Jan Brugués, Timothy J. Mitchison
Spatial Variation of Microtubule Depolymerization in Large Asters Suggests Regulation by MAP Depletion.
bioRxiv, Art. No. https://doi.org/10.1101/2020.06.26.172783 (2020)
Open Access DOI
---
Elisa Maria Rieckhoff, Frederic Berndt, Stefan Golfier, Franziska Decker, Maria Elsner, Keisuke Ishihara, Jan Brugués
Spindle scaling is governed by cell boundary regulation of microtubule nucleation.
bioRxiv, Art. No. https://doi.org/10.1101/2020.06.15.136937 (2020)
Open Access DOI
Elisa Maria Rieckhoff, Frederic Berndt, Stefan Golfier, Franziska Decker, Maria Elsner, Keisuke Ishihara, Jan Brugués
Spindle scaling is governed by cell boundary regulation of microtubule nucleation.
bioRxiv, Art. No. https://doi.org/10.1101/2020.06.15.136937 (2020)
Open Access DOI
---
Stefan Golfier, Thomas Quail, Hiroshi Kimura, Jan Brugués
Cohesin and condensin extrude DNA loops in a cell-cycle dependent manner.
Elife, 9 Art. No. e53885 (2020)
Open Access DOI
Stefan Golfier, Thomas Quail, Hiroshi Kimura, Jan Brugués
Cohesin and condensin extrude DNA loops in a cell-cycle dependent manner.
Elife, 9 Art. No. e53885 (2020)
Open Access DOI
---
Jonathan Rodenfels, Pablo Sartori, Stefan Golfier, Kartikeya Nagendra, Karla M. Neugebauer, Jonathon Howard
Contribution of increasing plasma membrane to the energetic cost of early zebrafish embryogenesis.
Mol Biol Cell, 31(7) 520-526 (2020)
DOI
Jonathan Rodenfels, Pablo Sartori, Stefan Golfier, Kartikeya Nagendra, Karla M. Neugebauer, Jonathon Howard
Contribution of increasing plasma membrane to the energetic cost of early zebrafish embryogenesis.
Mol Biol Cell, 31(7) 520-526 (2020)
DOI
---
Gunar Fabig#, Robert Kiewisz, Norbert Lindow, James A Powers, Vanessa Cota, Luis J Quintanilla, Jan Brugués, Steffen Prohaska, Diana S Chu, Thomas Müller-Reichert#
Male meiotic spindle features that efficiently segregate paired and lagging chromosomes.
Elife, 9 Art. No. e50988 (2020)
Open Access DOI
Gunar Fabig#, Robert Kiewisz, Norbert Lindow, James A Powers, Vanessa Cota, Luis J Quintanilla, Jan Brugués, Steffen Prohaska, Diana S Chu, Thomas Müller-Reichert#
Male meiotic spindle features that efficiently segregate paired and lagging chromosomes.
Elife, 9 Art. No. e50988 (2020)
Open Access DOI
---
David Oriola, Frank Jülicher, Jan Brugués
Active force generation shapes the metaphase spindle through a mechanical instability.
bioRxiv, Art. No. doi: 10.1101/2020.02.08.939868 (2020)
Open Access DOI
David Oriola, Frank Jülicher, Jan Brugués
Active force generation shapes the metaphase spindle through a mechanical instability.
bioRxiv, Art. No. doi: 10.1101/2020.02.08.939868 (2020)
Open Access DOI
2019
Paulo Caldas, Mar López-Pelegrín, Daniel J G Pearce, Nazmi Burak Budanur, Jan Brugués, Martin Loose
Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA.
Nat Commun, 10(1) Art. No. 5744 (2019)
Open Access DOI
Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA.
Nat Commun, 10(1) Art. No. 5744 (2019)
Open Access DOI
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Johannes Baumgart✳︎, Marcel Kirchner✳︎, Stefanie Redemann, Alec Bond, Jeffrey Woodruff, Jean-Marc Verbavatz, Frank Jülicher, Thomas Müller-Reichert, Anthony Hyman, Jan Brugués
Soluble tubulin is significantly enriched at mitotic centrosomes.
J Cell Biol, 218(12) 3977-3985 (2019)
DOI
Johannes Baumgart✳︎, Marcel Kirchner✳︎, Stefanie Redemann, Alec Bond, Jeffrey Woodruff, Jean-Marc Verbavatz, Frank Jülicher, Thomas Müller-Reichert, Anthony Hyman, Jan Brugués
Soluble tubulin is significantly enriched at mitotic centrosomes.
J Cell Biol, 218(12) 3977-3985 (2019)
DOI
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Stefan Golfier, Thomas Quail, Hiroshi Kimura, Jan Brugués
Cohesin and condensin extrude loops in a cell-cycle dependent manner
bioRxiv, Art. No. doi: 10.1101/821306 (2019)
Open Access
Stefan Golfier, Thomas Quail, Hiroshi Kimura, Jan Brugués
Cohesin and condensin extrude loops in a cell-cycle dependent manner
bioRxiv, Art. No. doi: 10.1101/821306 (2019)
Open Access
---
Elisa Maria Rieckhoff, Keisuke Ishihara, Jan Brugués
How to tune spindle size relative to cell size?
Curr Opin Cell Biol, 60 139-144 (2019)
DOI
Elisa Maria Rieckhoff, Keisuke Ishihara, Jan Brugués
How to tune spindle size relative to cell size?
Curr Opin Cell Biol, 60 139-144 (2019)
DOI
2018
Frederic Berndt, Gopi Shah, Rory M Power, Jan Brugués, Jan Huisken
Dynamic and non-contact 3D sample rotation for microscopy.
Nat Commun, 9(1) Art. No. 5025 (2018)
Open Access DOI
Dynamic and non-contact 3D sample rotation for microscopy.
Nat Commun, 9(1) Art. No. 5025 (2018)
Open Access DOI
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David Oriola, Daniel Needleman, Jan Brugués
The Physics of the Metaphase Spindle.
Ann Rev Biophys, 47 655-673 (2018)
DOI
David Oriola, Daniel Needleman, Jan Brugués
The Physics of the Metaphase Spindle.
Ann Rev Biophys, 47 655-673 (2018)
DOI
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Franziska Decker, David Oriola, Benjamin Dalton, Jan Brugues
Autocatalytic microtubule nucleation determines the size and mass of Xenopus laevis egg extract spindles.
Elife, 7 Art. No. e31149 (2018)
Open Access DOI
Franziska Decker, David Oriola, Benjamin Dalton, Jan Brugues
Autocatalytic microtubule nucleation determines the size and mass of Xenopus laevis egg extract spindles.
Elife, 7 Art. No. e31149 (2018)
Open Access DOI
2017
Stefanie Redemann, Johannes Baumgart, Norbert Lindow, Michael Shelley#, Ehssan Nazockdast, Andrea Kratz, Steffen Prohaska, Jan Brugués, Sebastian Fürthauer, Thomas Müller-Reichert#
C. elegans chromosomes connect to centrosomes by anchoring into the spindle network.
Nat Commun, 8 Art. No. 15288 (2017)
Open Access DOI
C. elegans chromosomes connect to centrosomes by anchoring into the spindle network.
Nat Commun, 8 Art. No. 15288 (2017)
Open Access DOI
2015
Ricard Alert, Jaume Casademunt, Jan Brugués, Pierre Sens
Model for probing membrane-cortex adhesion by micropipette aspiration and fluctuation spectroscopy.
Biophys J, 108(8) 1878-1886 (2015)
DOI
Model for probing membrane-cortex adhesion by micropipette aspiration and fluctuation spectroscopy.
Biophys J, 108(8) 1878-1886 (2015)
DOI
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Franziska Decker, Jan Brugués
Dissecting microtubule structures by laser ablation.
Methods Cell Biol, 125 61-75 (2015)
DOI
Franziska Decker, Jan Brugués
Dissecting microtubule structures by laser ablation.
Methods Cell Biol, 125 61-75 (2015)
DOI
2014
Jan Brugues, Daniel Needleman
Physical basis of spindle self-organization.
Proc Natl Acad Sci U.S.A., 111(52) 18496-18500 (2014)
PDF DOI
Physical basis of spindle self-organization.
Proc Natl Acad Sci U.S.A., 111(52) 18496-18500 (2014)
PDF DOI
---
Che-Hang Yu, Noah Langowitz, Hai-Yin Wu, Reza Farhadifar, Jan Brugues, Tae Yeon Yoo, Daniel Needleman
Measuring microtubule polarity in spindles with second-harmonic generation.
Biophys J, 106(8) 1578-1587 (2014)
PDF DOI
Che-Hang Yu, Noah Langowitz, Hai-Yin Wu, Reza Farhadifar, Jan Brugues, Tae Yeon Yoo, Daniel Needleman
Measuring microtubule polarity in spindles with second-harmonic generation.
Biophys J, 106(8) 1578-1587 (2014)
PDF DOI
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Dan Needleman, Jan Brugues
Determining physical principles of subcellular organization.
Dev Cell, 29(2) 135-138 (2014)
DOI
Dan Needleman, Jan Brugues
Determining physical principles of subcellular organization.
Dev Cell, 29(2) 135-138 (2014)
DOI
2012
Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel Needleman
Nucleation and transport organize microtubules in metaphase spindles.
Cell, 149(3) 554-564 (2012)
DOI
Nucleation and transport organize microtubules in metaphase spindles.
Cell, 149(3) 554-564 (2012)
DOI
2010
Javier G Orlandi, Carles Blanch-Mercader, Jan Brugués, Jaume Casademunt
Cooperativity of self-organized Brownian motors pulling on soft cargoes.
Phys Rev E, 82(6 Pt 1) 61903-61903 (2010)
Cooperativity of self-organized Brownian motors pulling on soft cargoes.
Phys Rev E, 82(6 Pt 1) 61903-61903 (2010)
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Benoît Maugis, Jan Brugués, Pierre Nassoy, Nancy Guillen, Pierre Sens, François Amblard
Dynamic instability of the intracellular pressure drives bleb-based motility.
J Cell Sci, 123(Pt 22) 3884-3892 (2010)
DOI
Benoît Maugis, Jan Brugués, Pierre Nassoy, Nancy Guillen, Pierre Sens, François Amblard
Dynamic instability of the intracellular pressure drives bleb-based motility.
J Cell Sci, 123(Pt 22) 3884-3892 (2010)
DOI
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Leann L Norman, Jan Brugués, Kheya Sengupta, Pierre Sens, Helim Aranda-Espinoza
Cell blebbing and membrane area homeostasis in spreading and retracting cells.
Biophys J, 99(6) 1726-1733 (2010)
DOI
Leann L Norman, Jan Brugués, Kheya Sengupta, Pierre Sens, Helim Aranda-Espinoza
Cell blebbing and membrane area homeostasis in spreading and retracting cells.
Biophys J, 99(6) 1726-1733 (2010)
DOI
---
Jan Brugués, Benoît Maugis, Jaume Casademunt, Pierre Nassoy, François Amblard, Pierre Sens
Dynamical organization of the cytoskeletal cortex probed by micropipette aspiration.
Proc Natl Acad Sci U.S.A., 107(35) 15415-15420 (2010)
DOI
Jan Brugués, Benoît Maugis, Jaume Casademunt, Pierre Nassoy, François Amblard, Pierre Sens
Dynamical organization of the cytoskeletal cortex probed by micropipette aspiration.
Proc Natl Acad Sci U.S.A., 107(35) 15415-15420 (2010)
DOI
---
Jan Brugués, Daniel Needleman
Nonequilibrium fluctuations in metaphase spindles: polarized light microscopy, image registration, and correlation functions
Proc SPIE, 7618 Art. No. 76180L (2010)
Jan Brugués, Daniel Needleman
Nonequilibrium fluctuations in metaphase spindles: polarized light microscopy, image registration, and correlation functions
Proc SPIE, 7618 Art. No. 76180L (2010)
2009
Jan Brugués, Jaume Casademunt
Self-organization and cooperativity of weakly coupled molecular motors under unequal loading.
Phys Rev Lett, 102(11) 118104-118104 (2009)
Self-organization and cooperativity of weakly coupled molecular motors under unequal loading.
Phys Rev Lett, 102(11) 118104-118104 (2009)
2008
Jan Brugués, Jordi Ignés-Mullol, Jaume Casademunt, Francesc Sagués
Probing elastic anisotropy from defect dynamics in Langmuir monolayers.
Phys Rev Lett, 100(3) 37801-37801 (2008)
Probing elastic anisotropy from defect dynamics in Langmuir monolayers.
Phys Rev Lett, 100(3) 37801-37801 (2008)
2006
Jan Brugués, Joaquim Gomis, Kiyoshi Kamimura
Newton-Hooke algebras, nonrelativistic branes, and generalized pp-wave metrics
Physical Review D, 73(8) Art. No. 085011 (2006)
Newton-Hooke algebras, nonrelativistic branes, and generalized pp-wave metrics
Physical Review D, 73(8) Art. No. 085011 (2006)
2005
Jan Brugués, Joan Rojo, Jorge G. Russo
Nonperturbative states in type II superstring theory from classical spinning membranes
Nucl Phys B, 710(1-2) 117-138 (2005)
Nonperturbative states in type II superstring theory from classical spinning membranes
Nucl Phys B, 710(1-2) 117-138 (2005)
2004
Jan Brugués, Thomas Curtright, Joaquim Gomis, Luca Mezincescu
Non-relativistic strings and branes as non-linear realizations of Galilei groups
Phys Lett B, 594(1-2) 227-233 (2004)
Non-relativistic strings and branes as non-linear realizations of Galilei groups
Phys Lett B, 594(1-2) 227-233 (2004)
2003
Jan Brugués, Joaquim Gomis, T. Mateos, T. Ramirez
Commutative and noncommutative= 2 SYM in (2+ 1) from wrapped D6-branes
Classical And Quantum Gravity, 20 null-null (2003)
Commutative and noncommutative= 2 SYM in (2+ 1) from wrapped D6-branes
Classical And Quantum Gravity, 20 null-null (2003)
2002
Jan Brugués, Joaquim Gomis, T. Mateos, T. Ramirez
Supergravity Duals of Noncommutative Wrapped D6 Branes and Supersymmetry without Supersymmetry
J High Energy Phys, 2002 null-null (2002)
Supergravity Duals of Noncommutative Wrapped D6 Branes and Supersymmetry without Supersymmetry
J High Energy Phys, 2002 null-null (2002)