The annotated database also provides information on where these proteins are expressed, with data for six different tissues comprising 23 cell types. The microscopy images were acquired in Drosophila melanogaster. The research team introduced the image library in the current issue of Developmental Cell.
The images are stored in an open access database, enabling the user to view and download all 3D image data. Moreover, all images have linked annotations that can also be searched.
The Rab machinery controls specific steps in intracellular lipid and protein traffic and thus serves researchers as logical target for manipulation of certain transport routes.
rablibrary.mpi-cbg.de
original paper:
Sebastian Dunst, Tom Kazimiers, Felix von Zadow, Helena Jambor, Andreas Sagner, Beate Brankatschk, Ali Mahmoud, Stephanie Spannl, Pavel Tomancak, Suzanne Eaton, Marko Brankatschk:
Endogenously Tagged Rab Proteins: A Resource to Study Membrane Trafficking in Drosophila
Developmental Cell, 4 May 2015