Heather Harrington Group

D Beers, D Goniotaki, DP Hanger, A Goriely, HA Harrington
Barcodes distinguishing morphology of neuronal tauopathy
Physical Review Research 5 (4), 043006
DOI

H Oliveri, DE Moulton, HA Harrington, A Goriely
Active shape control by plants in dynamic environments
arXiv preprint arXiv:2309.08950

W Reise, X Fernández, M Dominguez, HA Harrington, M Beguerisse-Díaz
Topological fingerprints for audio identification
arXiv preprint arXiv:2309.03516

Robert A. McDonald, Rosanna Neuhausler, Martin Robinson, Laurel G. Larsen, Heather A. Harrington, Maria Bruna
Zigzag persistence for coral reef resilience using a stochastic spatial model.
Journal of the Royal Society Interface 20 (205), 20230280

BJ Stolz, J Dhesi, JA Bull, HA Harrington, HM Byrne, IHR Yoon
Relational persistent homology for multispecies data with application to the tumor microenvironment
arXiv preprint arXiv:2308.06205

Jingjie Yang, Heidi Fang, Jagdeep Dhesi, Iris H.R. Yoon, Joshua A. Bull, Helen M. Byrne, Heather A. Harrington, Gillian Grindstaff
Topological classification of tumour-immune interactions and dynamics
arXiv preprint arXiv:2308.05294

Katherine Benjamin, Lamisah Mukta, Gabriel Moryoussef, Christopher Uren, Heather A. Harrington, Ulrike Tillmann and Agnese Barbensi
Homology of homologous knotted proteins
Journal of the Royal Society Interface 20 (201), 20220727
DOI

Z Gao, D Ghosh, HA Harrington, JG Restrepo, D Taylor
Dynamics on networks with higher-order interactions
Chaos: An Interdisciplinary Journal of Nonlinear Science 33 (4)
DOI

R Dong, C Goodbrake, HA Harrington, G Pogudin
Differential elimination for dynamical models via projections with applications to structural identifiability
SIAM Journal on Applied Algebra and Geometry 7 (1), 194-235

Hosuk Ryou, Korsuk Sirinukunwattana, Alan Aberdeen, Gillian Grindstaff, Bernadette J. Stolz, Helen Byrne, Heather A. Harrington, Nikolaos Sousos, Anna L. Godfrey, Claire N. Harrison, Bethan Psaila, Adam J. Mead, Gabrielle Rees, Gareth D. H. Turner, Jens Rittscher & Daniel Royston
Continuous Indexing of Fibrosis (CIF): Improving the assessment and classification of MPN patients
Leukemia 37 (2), 348-358
DOI

Uzu Lim, Rodrigo Leal Cervantes, Gillian Coughlan, Renaud Lambiotte, Hugo J. Spiers, Michael Hornberger, Heather A. Harrington
Geometry of navigation identifies genetic-risk and clinical Alzheimer's disease
medRxiv, 2023.10. 01.23296035
DOI

C Bick, E Gross, HA Harrington, MT Schaub
​​​​​​​What are higher-order networks?
SIAM Review 65 (3), 686-731

Lewis Marsh, Felix Y. Zhou, Xiao Qin, Xin Lu, Helen M. Byrne, Heather A. Harrington
Detecting Temporal shape changes with the Euler Characteristic Transform
arXiv preprint arXiv:2212.10883
DOI

Wilfred Offord, Michael Coughlan, Ian J. Hewitt, Heather A. Harrington, Gillian Grindstaff
Topological Data Analysis Detects Percolation Thresholds in Arctic Melt-Pond Evolution
arXiv preprint arXiv:2212.07961
DOI

Katherine Benjamin, Aneesha Bhandari, Zhouchun Shang, Yanan Xing, Yanru An, Nannan Zhang, Yong Hou, Ulrike Tillmann, Katherine R. Bull, Heather A. Harrington
Multiscale topology classifies and quantifies cell types in subcellular spatial transcriptomics
arXiv preprint arXiv:2212.06505
DOI

Heather A. Harrington, Mike Stillman, Alan Veliz-Cuba
Algebraic network reconstruction of discrete dynamical systems
arXiv preprint arXiv:2212.02601
DOI

Lewis Marsh, Emilie Dufresne, Helen M. Byrne, Heather A. Harrington
Algebra, geometry and topology of ERK kinetics
Bulletin of Mathematical Biology 84 (12), 137
DOI

David Beers, Heather A. Harrington, Alain Goriely
Stability of topological descriptors for neuronal morphology
arXiv preprint arXiv:2211.09058
DOI

Thomas Chaplin, Heather A. Harrington, Ulrike Tillmann
Grounded persistent path homology: a stable, topological descriptor for weighted digraphs
arXiv preprint arXiv:2210.11274
DOI

A Barbensi, HR Yoon, CD Madsen, DO Ajayi, MPH Stumpf, HA Harrington
Hypergraphs for multiscale cycles in structured data
arXiv preprint arXiv:2210.07545

CP Kotanidis, C Xie, D Alexander, JCL Rodrigues, K Burnham, A Mentzer, ...
Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19
The Lancet Digital Health 4 (10), e705-e716

RA McDonald, R Neuhausler, M Robinson, LG Larsen, HA Harrington, ...
Topological descriptors for coral reef resilience using a stochastic spatial model
arXiv preprint arXiv:2209.08974

C Goodbrake, D Beers, TB Thompson, HA Harrington, A Goriely
Brain Chains as Topological Signatures for Alzheimer's Disease
arXiv preprint arXiv:2208.12748

RS Hoekzema, L Marsh, O Sumray, TM Carroll, X Lu, HM Byrne, ...
Multiscale methods for signal selection in single-cell data
Entropy 24 (8), 1116

BJ Stolz, J Kaeppler, B Markelc, F Braun, F Lipsmeier, RJ Muschel, ...
Multiscale topology characterizes dynamic tumor vascular networks
Science Advances 8 (23), eabm2456

EL Brown, TL Lefebvre, PW Sweeney, BJ Stolz, J Gröhl, L Hacker, ...
Quantification of vascular networks in photoacoustic mesoscopy
Photoacoustics 26, 100357

T Thorne, PDW Kirk, HA Harrington
Topological approximate Bayesian computation for parameter inference of an angiogenesis model
Bioinformatics 38 (9), 2529-2535

A Seigal, HA Harrington, V Nanda
Principal components along quiver representations
Foundations of Computational Mathematics, 1-37

D Beers, D Goniotaki, DP Hanger, A Goriely, HA Harrington
Barcodes distinguish morphology of neuronal tauopathy
arXiv preprint arXiv:2204.03348

DJ Ahern, Z Ai, M Ainsworth, C Allan, A Allcock, B Angus, MA Ansari, ...
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Cell 185 (5), 916-938. e58

O Vipond, JA Bull, PS Macklin, U Tillmann, CW Pugh, HM Byrne, ...
Multiparameter persistent homology landscapes identify immune cell spatial patterns in tumors
Proceedings of the National Academy of Sciences 118 (41), e2102166118

JT Nardini, BJ Stolz, KB Flores, HA Harrington, HM Byrne
Topological data analysis distinguishes parameter regimes in the Anderson-Chaplain model of angiogenesis
PLOS Computational Biology 17 (6), e1009094

BJ Stolz, T Emerson, S Nahkuri, MA Porter, HA Harrington
Topological data analysis of task-based fMRI data from experiments on schizophrenia
Journal of Physics: Complexity 2 (3), 035006

E Dufresne, HA Harrington, JD Hauenstein, PG Kevrekidis, P Tripoli
On some configurations of oppositely charged trapped vortices in the plane
Advances in Applied Mathematics 124, 102099

COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium (203 authors, HAH member of integrative data analysis team).
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Cell 2022 185:916-938. medRXiv.

R Dong, C Goodbrake, HA Harrington, G Pogudin
Computing input-output projections of dynamical models with applications to structural identifiability.
CoRR

BJ Stolz, J Tanner, HA Harrington, V Nanda
Geometric anomaly detection in data
Proceedings of the national academy of sciences 117 (33), 19664-19669

E Gross, H Harrington, N Meshkat, A Shiu
Joining and decomposing reaction networks
Journal of mathematical biology 80, 1683-1731

MF Adamer, HA Harrington, EA Gaffney, TE Woolley
Coloured noise from stochastic inflows in reaction–diffusion systems
Bulletin of Mathematical Biology 82, 1-28

E Yeung, S McFann, L Marsh, E Dufresne, S Filippi, HA Harrington, ...
Inference of multisite phosphorylation rate constants and their modulation by pathogenic mutations
Current Biology 30 (5), 877-882. e6

A Barbensi, D Celoria, HA Harrington, A Stasiak, D Buck
Grid diagrams as tools to investigate knot spaces and topoisomerase-mediated simplification of DNA topology
Science advances 6 (9), eaay1458

HA Harrington, D Mehta, HM Byrne, JD Hauenstein
Decomposing the parameter space of biological networks via a numerical discriminant approach
Maple in Mathematics Education and Research: Third Maple Conference, MC 2019 …

Dufresne E, Edwards PB, Harrington HA, Hauenstein JD
Sampling real algebraic varieties for topological data analysis
2019 18th IEEE International Conference On Machine Learning And Applications (ICMLA) 2020 1531-1536. arXiv:1802.07716.

Byrne HM, Harrington HA,Muschel R, Reinert G, Stolz BJ, Tillmann U
Topology characterises spatial networks of tumour vasculature
Mathematics Today, 2019 55(5):206-210. arXiv:1907.08711.

E Gross, H Harrington, N Meshkat, A Shiu
Linear compartmental models: input-output equations and operations that preserve identifiability
SIAM Journal on Applied Mathematics 79 (4), 1423-1447

HA Harrington, N Otter, H Schenck, U Tillmann
Stratifying multiparameter persistent homology
SIAM Journal on Applied Algebra and Geometry 3 (3), 439-471

A Barbensi, D Buck, HA Harrington, M Lackenby
Double branched covers of knotoids
arXiv preprint arXiv:1811.09121

L Speidel, HA Harrington, SJ Chapman, MA Porter
Topological data analysis of continuum percolation with disks
Physical Review E 98 (1), 012318

MF Adamer, TE Woolley, HA Harrington
Graph-facilitated resonant mode counting in stochastic interaction networks
Journal of the Royal Society Interface 14 (137), 20170447

N Otter, MA Porter, U Tillmann, P Grindrod, HA Harrington
A roadmap for the computation of persistent homology
EPJ Data Science 6, 1-38

Smith RCG, Stumpf PS, Ridden SJ, Sim A, Filippi S, Harrington HA, MacArthur BD
Nanog fluctuations in embryonic stem cells highlight the problem of measurement in cell biology
Biophysical journal 112 (12), 2641-2652
DOI

BJ Stolz, HA Harrington, MA Porter
Persistent homology of time-dependent functional networks constructed from coupled time series
Chaos: An Interdisciplinary Journal of Nonlinear Science 27 (4)
DOI

Drellich E, Gainer-Dewar A, Harrington HA, He Q, Heitsch C, Poznanovic S.
Geometric combinatorics and computational molecular biology: Branching polytopes for RNA sequences
Accepted (to appear AMS Contemporary Mathematics Volume). arXiv:1509.04090. 

Kay SK, Harrington HA, Shepherd S, Brennan K, Dale T, Osborne JM, Gavaghan DJ, Byrne HM
The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt
PLoS computational biology 13 (2), e1005400
DOI

R Van Gorder, H Harrington
Reduction of dimension for nonlinear dynamical systems
Nonlinear Dynamics 88 (1)

E Gross, B Davis, KL Ho, DJ Bates, HA Harrington
Numerical algebraic geometry for model selection and its application to the life sciences
Journal of The Royal Society Interface 13 (123), 20160256
DOI

BJ Stolz, HA Harrington, MA Porter
The topological" shape" of Brexit
arXiv preprint arXiv:1610.00752

E Dufresne, HA Harrington, DV Raman
The geometry of sloppiness
arXiv preprint arXiv:1608.05679

D Levy, HA Harrington, RA Van Gorder
Role of seasonality on predator–prey–subsidy population dynamics
Journal of theoretical biology 396, 163-181

HA Harrington, KL Ho, N Meshkat
Differential algebra for model comparison
arXiv preprint arXiv:1603.09730

A Seigal, M Beguerisse-Diaz, B Schoeberl, M Niepel, HA Harrington
Tensors and algebra give interpretable groups for crosstalk mechanisms in breast cancer
arXiv preprint arXiv:1612.08116 1

E Gross, HA Harrington, Z Rosen, B Sturmfels
Algebraic systems biology: a case study for the Wnt pathway
Bulletin of mathematical biology 78, 21-51
DOI

AL MacLean, HA Harrington, MPH Stumpf, HM Byrne
Mathematical and statistical techniques for systems medicine: the Wnt signaling pathway as a case study
Systems Medicine, 405-439

*Taylor D, *Klimm F, Harrington HA, Kramar M, Mischaikow K, Porter MA, Mucha PJ.
Topological data analysis of contagion maps for examining spreading processes on networks
Nature communications 6 (1), 7723 

AL MacLean, Z Rosen, HM Byrne, HA Harrington
Parameter-free methods distinguish Wnt pathway models and guide design of experiments
Proceedings of the National Academy of Sciences 112 (9), 2652-2657

Jonanovic G, Sheng X, Ale A, Feliu E, Harrington HA, Kirk P, Wiuf C, Buck M, Stumpf MPH.
Phosphorelay of non-orthodox two component systems functions through a bi-molecular mechanism in vivo: the case of ArcB
Molecular BioSystems 11 (5), 1348-1359

AL MacLean, HA Harrington, MPH Stumpf, MDH Hansen
Epithelial-mesenchymal transition in metastatic cancer cell populations affects tumor dormancy in a simple mathematical model
Biomedicines 2 (4), 384-402

Michailovici I, Harrington H, Azogui HH, Yahalom-Ronen Y, Plotnikov A, Ching S, Stumpf MPH, Klein OD, Seger R, Tzahor E.
Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells
Development 141 (13), 2611-2620

HA Harrington, E Feliu, C Wiuf, MPH Stumpf
Cellular compartments cause multistability and allow cells to process more information
Biophysical journal 104 (8), 1824-1831

HA Harrington, MB Díaz, MP Rombach, LM Keating, MA Porter
Teach network science to teenagers
arXiv preprint arXiv:1302.6567

Chaidos A, Barnes C, Cowan G, May P, Melo V, Hatjiharissi E, Papaioannou M, Harrington H, Doolittle H, Terpos E, Abdalla S, Yarranton H, Naresh K, Foroni L, Reid A, Rahemtulla A, Stumpf M, Roberts I, Karadimitris A.
Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma
Blood, The Journal of the American Society of Hematology 121 (2), 318-328