Research Groups

2018

Celina Galles, Gastón M Prez, Sider Penkov, Sebastian Boland, Exequiel O J Porta, Silvia G Altabe, Guillermo R Labadie, Ulrike Schmidt, Hans-Joachim Knölker, Teymuras V. Kurzchalia, Diego Mendoza
Endocannabinoids in Caenorhabditis elegans are essential for the mobilization of cholesterol from internal reserves.
Sci Rep, 8(1) Art. No. 6398 (2018)

2017

Yusuke Toyoda, Cedric J Cattin, Martin P Stewart, Ina Poser, Mirko Theis, Teymuras V. Kurzchalia, Frank Buchholz, Anthony Hyman, Daniel J. Müller
Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding.
Nat Commun, 8(1) Art. No. 1266 (2017)
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Sebastian Boland, Ulrike Schmidt, Vyacheslav Zagoriy, Julio Sampaio, Raphael F Fritsche, Regina Czerwonka, Tilo Lübken, Jakob Reimann, Sider Penkov, Hans-Joachim Knölker, Teymuras V. Kurzchalia
Phosphorylated glycosphingolipids essential for cholesterol mobilization in Caenorhabditis elegans.
Nat Chem Biol, 13(6) 647-654 (2017)
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Damla Kaptan
Metabolic Transition in Caenorhabditis elegans Dauer Larva
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2017)

2016

Cihan Erkut, Vamshidhar Gade, Sunil Laxman, Teymuras V. Kurzchalia
The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast.
Elife, 5 Art. No. e13614 (2016)
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Mykola Mylenko, Sebastian Boland, Sider Penkov, Julio Sampaio, Benoit Lombardot, Daniela Vorkel, Jean-Marc Verbavatz, Teymuras V. Kurzchalia
NAD+ Is a Food Component That Promotes Exit from Dauer Diapause in Caenorhabditis elegans.
PLoS ONE, 11(12) Art. No. e0167208 (2016)

2015

Mykola Mylenko
Identification and biochemical characterization of food signal in Caenorhabditis elegans
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2015)
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Cihan Erkut, Teymuras V. Kurzchalia
The C. elegans dauer larva as a paradigm to study metabolic suppression and desiccation tolerance.
Planta, 242(2) 389-396 (2015)
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Sider Penkov, Damla Kaptan, Cihan Erkut, Mihail Sarov, Fanny Mende, Teymuras V. Kurzchalia
Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans.
Nat Commun, 6 Art. No. 8060 (2015)

2014

Sawsan E Abusharkh, Cihan Erkut, Jana Oertel, Teymuras V. Kurzchalia, Karim Fahmy
The Role of Phospholipid Headgroup Composition and Trehalose in the Desiccation Tolerance of Caenorhabditis elegans.
Langmuir, 30(43) 12897-12906 (2014)
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Yusuke Toyoda, Cihan Erkut, Francisco Pan-Montojo, Sebastian Boland, Martin P Stewart, Daniel J. Müller, Wolfgang Wurst, Anthony Hyman, Teymuras V. Kurzchalia
Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival.
Biol Open, 3(8) 777-784 (2014)
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Sider Penkov, Akira Ogawa, Ulrike Schmidt, Dhananjay Tate, Vyacheslav Zagoriy, Sebastian Boland, Margit Gruner, Daniela Vorkel, Jean-Marc Verbavatz, Ralf J Sommer, Hans-Joachim Knölker, Teymuras V. Kurzchalia
A wax ester promotes collective host finding in the nematode Pristionchus pacificus.
Nat Chem Biol, 10(4) 281-285 (2014)
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Cyrus Papan, Sider Penkov, Ronny Herzog, Christoph Thiele, Teymuras V. Kurzchalia, Andrej Shevchenko
Systematic screening for novel lipids by shotgun lipidomics.
Anal Chem, 86(5) 2703-2710 (2014)

2013

Cihan Erkut, Andrej Vasilj, Sebastian Boland, Bianca Habermann, Andrej Shevchenko, Teymuras V. Kurzchalia
Molecular Strategies of the Caenorhabditis elegans Dauer Larva to Survive Extreme Desiccation.
PLoS ONE, 8(12) Art. No. e82473 (2013)

2012

Kim Schneider, Thomas Köcher, Teemu Andersin, Teymuras V. Kurzchalia, Ueli Schibler, David Gatfield
CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions.
EMBO Rep, 13(12) 1138-1144 (2012)
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Ratni Saini, Sebastian Boland, Olga Kataeva, Arndt W Schmidt, Teymuras V. Kurzchalia, Hans-Joachim Knölker
Stereoselective synthesis and hormonal activity of novel dafachronic acids and naturally occurring steroids isolated from corals.
Org Biomol Chem, 10(21) 4159-4163 (2012)
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Cihan Erkut, Sider Penkov, Karim Fahmy, Teymuras V. Kurzchalia
How worms survive desiccation: Trehalose pro water.
Worm, 1(1) 61-65 (2012)

2011

Ulrike Pässler, Margit Gruner, Sider Penkov, Teymuras V. Kurzchalia, Hans-Joachim Knölker
Synthesis of Ten Members of the Maradolipid Family; Novel Diacyltrehalose Glycolipids from Caenorhabditis elegans
SYNLETT, 22(17) 2482-2486 (2011)
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Cihan Erkut, Sider Penkov, Hassan Khesbak, Daniela Vorkel, Jean-Marc Verbavatz, Karim Fahmy, Teymuras V. Kurzchalia
Trehalose renders the dauer larva of Caenorhabditis elegans resistant to extreme desiccation.
Curr Biol, 21(15) 1331-1336 (2011)
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Sider Penkov
Trehalose and trehalose lipids in Caenorhabditis elegans dauer larva
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2011)

2010

Sider Penkov, Fanny Mende, Vyacheslav Zagoriy, Cihan Erkut, René Martin, Ulrike Pässler, Kai Schuhmann, Dominik Schwudke, Margit Gruner, Jana Mäntler, Thomas Müller-Reichert, Andrej Shevchenko, Hans-Joachim Knölker, Teymuras V. Kurzchalia
Maradolipids: Diacyltrehalose Glycolipids Specific to Dauer Larva in Caenorhabditis elegans.
Angew Chem Int Ed Engl, 49(49) 9430-9435 (2010)
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Maria Carvalho, Dominik Schwudke, Julio Sampaio, Wilhelm Palm, Isabelle Riezman, Gautam Dey, Gagan D Gupta, Satyajit Mayor, Howard Riezman, Andrej Shevchenko, Teymuras V. Kurzchalia, Suzanne Eaton
Survival strategies of a sterol auxotroph.
Development, 137(21) 3675-3685 (2010)
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Vyacheslav Zagoriy, Vitali Matyash, Teymuras V. Kurzchalia
Long-chain O-ascarosyl-alkanediols are constitutive components of Caenorhabditis elegans but do not induce dauer larva formation.
Chem Biodivers, 7(8) 2016-2022 (2010)
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Pablo S Aguilar, Maxwell G Heiman, Tobias C Walther, Alex Engel, Dominik Schwudke, Nathan Gushwa, Teymuras V. Kurzchalia, Peter Walter
Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating.
Proc Natl Acad Sci U.S.A., 107(9) 4170-4175 (2010)
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René Martin, Eugeni V. Entchev, Teymuras V. Kurzchalia, Hans-Joachim Knölker
Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology.
Org Biomol Chem, 8(4) 739-750 (2010)

2009

Vyacheslav Zagoriy
Long chain O-ascarosyl alkanediols (ascarosides) of Caenorhabditis elegans
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2009)
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René Martin, Tina Schäfer, Gabriele Theumer, Eugeni V. Entchev, Teymuras V. Kurzchalia, Hans-Joachim Knölker
Improved Synthesis of an Ascaroside Pheromone Controlling Dauer Larva Development in Caenorhabditis elegans
Synthesis, 41(20) 3488-3492 (2009)
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René Martin, Eugeni V. Entchev, Frank Däbritz, Teymuras V. Kurzchalia, Hans-Joachim Knölker
Synthesis and Hormonal Activity of the (25S)-Cholesten-26-oic Acids – Potent Ligands for the DAF-12 Receptor in Caenorhabditis elegans
Eur J Org Chem, (22) 3703-3714 (2009)
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J Thomas Hannich, Eugeni V. Entchev, Fanny Mende, Hristio Boytchev, René Martin, Vyacheslav Zagoriy, Gabriele Theumer, Isabelle Riezman, Howard Riezman, Hans-Joachim Knölker, Teymuras V. Kurzchalia
Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans.
Dev Cell, 16(6) 833-843 (2009)
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René Martin, Ratni Saini, Ingmar Bauer, Margit Gruner, Olga Kataeva, Vyacheslav Zagoriy, Eugeni V. Entchev, Teymuras V. Kurzchalia, Hans-Joachim Knölker
4Alpha-bromo-5alpha-cholestan-3beta-ol and nor-5alpha-cholestan-3beta-ol derivatives-stereoselective synthesis and hormonal activity in Caenorhabditis elegans.
Org Biomol Chem, 7(11) 2303-2309 (2009)
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René Martin, Arndt W Schmidt, Gabriele Theumer, Tilo Krause, Eugeni V. Entchev, Teymuras V. Kurzchalia, Hans-Joachim Knölker
Synthesis and biological activity of the (25R)-cholesten-26-oic acids--ligands for the hormonal receptor DAF-12 in Caenorhabditis elegans.
Org Biomol Chem, 7(5) 909-920 (2009)
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Gaspare Benenati, Sider Penkov, Thomas Müller-Reichert, Eugeni V. Entchev, Teymuras V. Kurzchalia
Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and the polarization of embryo.
Mech Dev, 126(5-6) 382-393 (2009)
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J Thomas Hannich
Lipid methylation in the development of Caenorhabditits elegans
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2009)

2008

René Martin, Frank Däbritz, Eugeni V. Entchev, Teymuras V. Kurzchalia, Hans-Joachim Knölker
Stereoselective synthesis of the hormonally active (25S)-delta7-dafachronic acid, (25S)-Delta4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid.
Org Biomol Chem, 6(23) 4293-4295 (2008)
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Eugeni V. Entchev, Dominik Schwudke, Vyacheslav Zagoriy, Vitali Matyash, Aliona Bogdanova, Bianca Habermann, Lin Zhu, Andrej Shevchenko, Teymuras V. Kurzchalia
LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans.
J Biol Chem, 283(25) 17550-17560 (2008)
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Susanne Heimerl, Gerhard Liebisch, Soazig Le Lay, Alfred Böttcher, Philipp Wiesner, Silke Lindtner, Teymuras V. Kurzchalia, Kai Simons, Gerd Schmitz
Caveolin-1 deficiency alters plasma lipid and lipoprotein profiles in mice.
Biochem Biophys Res Commun, 367(4) 826-833 (2008)
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Magalie Lebreton
New outlooks on the transport of cholesterol in Caenorhabditis elegans
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2008)

2006

Manuel A Fernández, Cecilia Albor, Mercedes Ingelmo-Torres, Susan J. Nixon, Charles Ferguson, Teymuras V. Kurzchalia, Francesc Tebar, Carlos Enrich, Robert G. Parton, Albert Pol
Caveolin-1 is essential for liver regeneration.
Science, 313(5793) 1628-1632 (2006)
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Jens Waschke, Nikola Golenhofen, Teymuras V. Kurzchalia, Detlev Drenckhahn
Protein kinase C-mediated endothelial barrier regulation is caveolin-1-dependent.
Histochem Cell Biol, 126(1) 17-26 (2006)
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Jun Yu, Sonia Bergaya, Takahisa Murata, Ilkay F. Alp, Michael P. Bauer, Michelle I Lin, Marek Drab, Teymuras V. Kurzchalia, Radu V Stan, William C Sessa
Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels.
J Clin Invest, 116(5) 1284-1291 (2006)
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Arndt W Schmidt, Thomas Doert, Sigrid Goutal, Margit Gruner, Fanny Mende, Teymuras V. Kurzchalia, Hans-Joachim Knölker
Regio- and Stereospecific Synthesis of Cholesterol Derivatives and their Hormonal Activity in Caenorhabditis elegans
Eur J Org Chem, 16 3687-3706 (2006)

2005

Soazig Le Lay, Teymuras V. Kurzchalia
Getting rid of caveolins: phenotypes of caveolin-deficient animals.
Biochim Biophys Acta, 1746(3) 322-333 (2005)
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Agathi Papanikolaou, Alexandra Papafotika, Carol Murphy, Thomais Papamarcaki, Orestes Tsolas, Marek Drab, Teymuras V. Kurzchalia, Michael Kasper, Savvas Christoforidis
Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39.
J Biol Chem, 280(28) 26406-26414 (2005)
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Eugeni V. Entchev, Teymuras V. Kurzchalia
Requirement of sterols in the life cycle of the nematode Caenorhabditis elegans.
Semin Cell Dev Biol, 16(2) 175-182 (2005)
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Kirsten Bacia, Petra Schwille, Teymuras V. Kurzchalia
Sterol structure determines the separation of phases and the curvature of the liquid-ordered phase in model membranes.
Proc Natl Acad Sci U.S.A., 102(9) 3272-3277 (2005)
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Matthew Kirkham, Akikazu Fujita, Rahul Chadda, Susan J. Nixon, Teymuras V. Kurzchalia, Deepak K Sharma, Richard E Pagano, John F. Hancock, Satyajit Mayor, Robert G. Parton
Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles.
J Cell Biol, 168(3) 465-476 (2005)
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Eva-Maria Damm, Lucas Pelkmans, Jürgen Kartenbeck, Anna Mezzacasa, Teymuras V. Kurzchalia, Ari Helenius
Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae.
J Cell Biol, 168(3) 477-488 (2005)

2004

Vitali Matyash, Eugeni V. Entchev, Fanny Mende, Michaela Wilsch-Bräuninger, Christoph Thiele, Arndt W Schmidt, Hans-Joachim Knölker, Samuel Ward, Teymuras V. Kurzchalia
Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16.
PLoS Biol, 2(10) 280-280 (2004)

2003

Teymuras V. Kurzchalia, Samuel Ward
Why do worms need cholesterol?
Nat Cell Biol, 5(8) 684-688 (2003)
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H Lucius, Tim Friedrichson, Teymuras V. Kurzchalia, G R Lewin
Identification of caveolae-like structures on the surface of intact cells using scanning force microscopy.
J Membr Biol, 194(2) 97-108 (2003)
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Teymuras V. Kurzchalia
Anthrax toxin rafts into cells.
J Cell Biol, 160(3) 295-296 (2003)
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Bruce D. Wyse, Ian A. Prior, Hongwei Qian, Isabel C. Morrow, Susan J. Nixon, Cornelia Muncke, Teymuras V. Kurzchalia, Walter G. Thomas, Robert G. Parton, John F. Hancock
Caveolin Interacts with the Angiotensin II Type 1 Receptor during Exocytic Transport but Not at the Plasma Membrane
J Biol Chem, 278(26) 23738-23746 (2003)

2001

Marek Drab, Paul Verkade, Marlies Elger, Michael Kasper, Matthias Lohn, Birgit Lauterbach, Jan Menne, Carsten Lindschau, Fanny Mende, Friedrich C. Luft, Aandreas Schedl, Hermann Haller, Teymuras V. Kurzchalia
Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice.
Science, 293(5539) 2449-2452 (2001)
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Vitali Matyash, Christian Geier, Annemarie Henske, Sushmita Mukherjee, David Hirsh, Christoph Thiele, Barth Grant, Frederick R. Maxfield, Teymuras V. Kurzchalia
Distribution and transport of cholesterol in Caenorhabditis elegans.
Mol Biol Cell, 12(6) 1725-1736 (2001)

1999

Mikael Simons, Tim Friedrichson, Jörg B Schulz, Marina Pitto, Massimo Masserini, Teymuras V. Kurzchalia
Exogenous administration of gangliosides displaces GPI-anchored proteins from lipid microdomains in living cells.
Mol Biol Cell, 10(10) 3187-3196 (1999)
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Teymuras V. Kurzchalia, Robert G. Parton
Membrane microdomains and caveolae.
Curr Opin Cell Biol, 11(4) 424-431 (1999)
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Jochen Scheel, Jagan Srinivasan, Ulrike Honnert, Annemarie Henske, Teymuras V. Kurzchalia
Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans.
Nat Cell Biol, 1(2) 127-129 (1999)