Research Groups


Máté Pálfy, Gunnar Schulze, Eivind Valen, Nadine Vastenhouw
Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation.
PLoS Genet, 16(1) Art. No. e1008546 (2020)


Yuko Sato, Lennart Hilbert, Haruka Oda, Yinan Wan, John M Heddleston, Teng-Leong Chew, Vasily Zaburdaev, Philipp Keller, Timothee Lionnet, Nadine Vastenhouw, Hiroshi Kimura
Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis.
Development, 146(19) Art. No. dev179127 (2019)
Nadine Vastenhouw, Wen Xi Cao, Howard D Lipshitz
The maternal-to-zygotic transition revisited.
Development, 146(11) Art. No. dev161471 (2019)


Máté Pálfy
The role of transcription factors in shaping the chromatin landscape and regulating the timing of zygotic genome activation in zebrafish
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2018)
Pavel Vopalensky, Sabrina Pralow, Nadine Vastenhouw
Reduced expression of the Nodal co-receptor Oep causes loss of mesendodermal competence in zebrafish.
Development, 145(5) Art. No. dev158832 (2018)
Mukesh Kumar, Shai Joseph, Martina Augsburg, Aliona Bogdanova, David N. Drechsel, Nadine Vastenhouw, Frank Buchholz, Marc Gentzel, Andrej Shevchenko
MS Western, a Method of Multiplexed Absolute Protein Quantification is a Practical Alternative to Western Blotting.
Mol Cell Proteomics, 17(2) 384-396 (2018)
L Carine Stapel, Coleman Broaddus, Nadine Vastenhouw
Detection and Automated Analysis of Single Transcripts at Subcellular Resolution in Zebrafish Embryos.
Methods Mol Biol, 1649 143-162 (2018)


Shai Joseph
Competition for DNA binding between histones and transcription factors regulates the timing of zygotic genome activation in zebrafish embryos
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2017)
L Carine Stapel, Christoph Zechner, Nadine Vastenhouw
Uniform gene expression in embryos is achieved by temporal averaging of transcription noise.
Genes Dev, 31(16) 1635-1640 (2017)
Tobias Boothe, Lennart Hilbert, Michael Heide, Lea Berninger, Wieland B. Huttner, Vasily Zaburdaev, Nadine Vastenhouw, Eugene W Myers, David N. Drechsel, Jochen Rink
A tunable refractive index matching medium for live imaging cells, tissues and model organisms.
Elife, 6 Art. No. e27240 (2017)
Shai Joseph, Máté Pálfy, Lennart Hilbert, Mukesh Kumar, Jens Karschau, Vasily Zaburdaev, Andrej Shevchenko, Nadine Vastenhouw
Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos.
Elife, 6 Art. No. e23326 (2017)
Máté Pálfy, Shai Joseph, Nadine Vastenhouw
The timing of zygotic genome activation.
Curr Opin Genet Dev, 43 53-60 (2017)
Maximilian Krause
The role of Histone H3 Lysine 4 trimethylation in zebrafish embryonic development
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2017)


L Carine Stapel
The road to uniform gene expression
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2016)
L Carine Stapel, Benoit Lombardot, Coleman Broaddus, Dagmar Kainmueller, Florian Jug, Eugene W Myers, Nadine Vastenhouw
Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos.
Development, 143(3) 540-546 (2016)


L Carine Stapel, Nadine Vastenhouw
Message control in developmental transitions; deciphering chromatin's role using zebrafish genomics.
Brief Funct Genomics, 13(2) 106-120 (2014)
Yong Zhang, Nadine Vastenhouw, Jianxing Feng, Kai Fu, Chenfei Wang, Ying Ge, Paul van Hummelen, Alexander F Schier, Xiaole Shirley Liu
Canonical nucleosome organization at promoters forms during genome activation.
Genome Res, 24(2) 260-266 (2014)


Nadine Vastenhouw, Alexander F Schier
Bivalent histone modifications in early embryogenesis.
Curr Opin Cell Biol, 24(3) 374-386 (2012)
Andrea Pauli, Eivind Valen, Michael F Lin, Manuel Garber, Nadine Vastenhouw, Joshua Z Levin, Lin Fan, Albin Sandelin, John L Rinn, Aviv Regev, Alexander F Schier
Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis.
Genome Res, 22(3) 577-591 (2012)


Nadine Vastenhouw, Yong Zhang, Ian G Woods, Farhad Imam, Aviv Regev, X Shirley Liu, John L Rinn, Alexander F Schier
Chromatin signature of embryonic pluripotency is established during genome activation.
Nature, 464(7290) 922-926 (2010)


Nadine Vastenhouw, Karin Brunschwig, Kristy L Okihara, Fritz Müller, Marcel Tijsterman, Ronald H A Plasterk
Gene expression: long-term gene silencing by RNAi.
Nature, 442(7105) 882-882 (2006)


Gijs van Haaften, Nadine Vastenhouw, Ellen A A Nollen, Ronald H A Plasterk, Marcel Tijsterman
Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality.
Proc Natl Acad Sci U.S.A., 101(35) 12992-12996 (2004)
Nadine Vastenhouw, Ronald H A Plasterk
RNAi protects the Caenorhabditis elegans germline against transposition.
Trends Genet, 20(7) 314-319 (2004)
V J P Robert, Nadine Vastenhouw, Ronald H A Plasterk
RNA interference, transposon silencing, and cosuppression in the Caenorhabditis elegans germ line: similarities and differences.
Cold Spring Harb Symp Quant Biol, 69 397-402 (2004)


Nadine Vastenhouw, Steffi Fischer, V J P Robert, Karen L Thijssen, Andrew G Fraser, Ravi S Kamath, Julie Ahringer, Ronald H A Plasterk
A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans.
Curr Biol, 13(15) 1311-1316 (2003)


H Masselink, Nadine Vastenhouw, René Bernards
B-myb rescues ras-induced premature senescence, which requires its transactivation domain.
Cancer Lett, 171(1) 87-101 (2001)
B Berkhout, Nadine Vastenhouw, B I Klasens, H Huthoff
Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription.
RNA, 7(8) 1097-1114 (2001)