Michael Hiller

Scientific Career

since 2011
Research Group Leader, jointly at the MPI-CBG and the Max Planck Institute for the Physics of Complex Systems, Dresden
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2008-2011
Postdoctoral work at Stanford University, Department of Developmental Biology, USA
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2007-2008
Postdoctoral work at University of Freiburg, Bioinformatics Group, Germany
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2002-2006
PhD in Bioinformatics, University of Jena and University of Freiburg, Germany

Awards

2013
German Life Science Award
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2009-2011
Long-term Postdoc Fellowship from the Human Frontier Science Program (HFSP)
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2008-2009
Postdoc fellowship from the German Research Foundation

Popular Science

Hiller M. Forward Genomics – ein neuer Ansatz der vergleichenden Sequenzanalyse. Biologie in unserer Zeit, 43(1), 34–39, 2013 (in German)

Platzer M, Hiller M, Huse K, Szafranski K, Hampe J, Backofen R, and Schreiber S. Die Variabilität der Plastizität - Proteinvielfalt durch subtiles alternatives Spleißen an NAGNAG-Motiven. GenomXpress, Nr. 1/06, 4-6, 2006 (in German)

Platzer M, Huse K, and Hiller M. Alternatives Spleißen an NAGNAG-Motiven: kleine Ursache - große Protein-Vielfalt. Biologie In Unserer Zeit, 35(2), 80-82, 2005 (in German)

Selected publications

Sharma V, Hiller M (2017) Increased alignment sensitivity improves the usage of genome alignments for comparative gene annotation. Nucleic Acids Res, 45(14) 8369-8377.

Suarez H, Langer B, Ladde P, Hiller M (2017). chainCleaner improves genome alignment specificity and sensitivity. Bioinformatics, 33(11) 1596-1603.

Prudent X, Parra G, Schwede P, Roscito JG, Hiller M (2016). Controlling for phylogenetic relatedness and evolutionary rates improves the discovery of associations between species’ phenotypic and genomic differences. Mol Biol Evol, 33(8), 2135-5.
See also MBE News.

Sharma V, Elghafari A, Hiller M (2016): Coding Exon-Structure Aware Realigner (CESAR) utilizes genome alignments for accurate comparative gene annotation. Nucleic Acids Res, 44(11), e103.

Hiller M, Agarwal S, Notwell JH, Parikh R, Guturu H, Wenger AM, Bejerano G (2013): Computational methods to detect conserved non-genic elements in phylogenetically isolated genomes: application to zebrafish. Nucleic Acids Res, 41(15):e151.

Hiller M, Schaar BT, Indjeian VB, Kingsley DM, Hagey LR, and Bejerano G. (2012): A “forward genomics” approach links genotype to phenotype using independent phenotypic losses among related species. Cell Reports, 2(4), 817-823.
Read more on F1000 and HFSP

McLean CY, Bristor D, Hiller M, Clarke SL, Schaar BT, Lowe CB, Wenger AM, Bejerano G. (2010): GREAT improves functional interpretation of cis-regulatory regions. Nature Biotechnol., 28(5), 495-501

Hiller M, Findeiss S, Lein S, Marz M, Nickel C, Rose D, Schulz C, Backofen R, Prohaska SJ, Reuter G and Stadler PF. (2009):  Conserved Introns Reveal Novel Transcripts in Drosophila melanogaster. Genome Res. 19(7), 1289-1300

Hiller M*, Huse K*, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R, and Platzer M. (2004): Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity. Nature Genet. 36(12), 1255-7

Funding

In addition to generous funding from the Max Planck Society, our research is supported by