Research Groups

Future projects and goals

Define the information flows that shape the (st)embryo: Which cellular interactions drive mammalian embryo-like architecture? How are forces, form and fate coordinated? By direct comparison of stembryos with different levels of morphogenetic complexity, we define the inputs that sculpt the embryo across space and time.

Learning from variation: The embryo is always right. The stembryo is often wrong. We develop frameworks to leverage variation by backtracking causative developmental dynamics. This delivers novel biological insights and provides means to control and steer development in a dish.

Building better models: We implement design principles of the embryo to build better stembryos. Moreover, we aim to establish human stembryos from pluripotent stem cells to study the molecular, cellular and morphogenetic processes that shape the human embryo in health and disease. 

Philosophy

We will work with a small team on big questions. This means that, just like the cells we study, we have to communicate and act as a collective to ensure that Team Stembryo is more than the sum of its parts. Many projects are cross-disciplinary and will involve dynamic dialogues with biophysicists, modellers and engineers. Science is more fun when you collaborate!

Are you an out-of-the-box thinker and tinkerer? Do you prefer collaboration over competition? Are you excited about stembryogenesis, while appreciating the rich history of embryogenesis? Then we might be a great match! 

For collaborations, internships, PhD and postdoc positions, please contact veenvliet@mpi-cbg.de

Methodological and technical expertise

  • 3D in vitro modelling of mammalian development (a.o. gastruloids, trunk-like-structures)
  • Comparative (single-cell) transcriptomics
  • High-throughput wide-field live imaging
  • Embryonic stem cell culture and differentiation