Research Groups


Volker Hartenstein, Michaela Yuan, Amelia Younossi-Hartenstein, Aanavi Karandikar, F Javier Bernardo-Garcia, Simon Sprecher, Elisabeth Knust
Serial electron microscopic reconstruction of the drosophila larval eye: Photoreceptors with a rudimentary rhabdomere of microvillar-like processes.
Dev Biol, Art. No. doi: 10.1016/j.ydbio.2019.05.017 (2019)
Satu Kujawski, Mahendra Sonawane, Elisabeth Knust
penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina.
Biol Open, 8(4) Art. No. bio041830 (2019)
Sara Caviglia, David Flores-Benitez, Johanna Lattner, Stefan Luschnig, Marko Brankatschk
Rabs on the fly: Functions of Rab GTPases during development.
Small GTPases, 10(2) 89-98 (2019)
Dimitrios Papadopoulos, Kassiani Skouloudaki, Ylva Engström, Lars Terenius, Rudolf Rigler, Christoph Zechner, Vladana Vukojević, Pavel Tomancak
Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch.
Development, 146(12) Art. No. dev168179 (2019)
Kassiani Skouloudaki, Dimitrios Papadopoulos, Pavel Tomancak, Elisabeth Knust
The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation.
PLoS Genet, 15(1) Art. No. e1007852 (2019)
Malte Lehmann, Elisabeth Knust, Sarita Hebbar
Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa.
Methods Mol Biol, 1834 221-249 (2019)
Monalisa Mishra, Elisabeth Knust
Analysis of the Drosophila Compound Eye with Light and Electron Microscopy.
Methods Mol Biol, 1834 345-364 (2019)


Catia Crespo, Elisabeth Knust
Characterisation of maturation of photoreceptor cell subtypes during zebrafish retinal development.
Biol Open, 7(11) Art. No. bio036632 (2018)
Catia Crespo, Daniele Soroldoni, Elisabeth Knust
A novel transgenic zebrafish line for red opsin expression in outer segments of photoreceptor cells.
Dev Dyn, 247(7) 951-959 (2018)
Giorgos Tsoumpekos, Linda Nemetschke, Elisabeth Knust
Drosophila Big bang regulates the apical cytocortex and wing growth through junctional tension.
J Cell Biol, 217(3) 1033-1045 (2018)
Shradha Das, Elisabeth Knust
A dual role of the extracellular domain of DrosophilaCrumbs for morphogenesis of the embryonic neuroectoderm.
Biol Open, 7(1) Art. No. bio031435 (2018)
Alejandro Vignoni, Anna Bajur, Elisabeth Knust, Ivo F. Sbalzarini
Multi-objective identification from fluorescence recovery after photobleaching experiments: Understanding morphogenetic regulation of epithelial polarity
IFAC-PapersOnLine, 51(19) 8-11 (2018)


Arturo Raya-Sandino, Alejandro Castillo-Kauil, Alaide Domínguez-Calderón, Lourdes Alarcón, David Flores-Benitez, Francisco Cuellar-Perez, Bruno López-Bayghen, Bibiana Chávez-Munguía, José Vázquez-Prado, Lorenza González-Mariscal
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
Biochim Biophys Acta, 1864(10) 1714-1733 (2017)
Shradha Das, Elisabeth Knust
Stardust, the Janus-faced partner of Crumbs.
J Cell Biol, 216(5) 1219-1221 (2017)
Stephanie Spannl, Alexandra Kumichel, Sarita Hebbar, Katja Kapp, Marcos Gonzalez-Gaitan, Sylke Winkler, Rosana Blawid, Gregor Jessberger, Elisabeth Knust
The Crumbs_C isoform of Drosophila shows tissue- and stage-specific expression and prevents light-dependent retinal degeneration.
Biol Open, 6(2) 165-175 (2017)


Linda Nemetschke, Elisabeth Knust
Drosophila Crumbs prevents ectopic Notch activation in developing wings by inhibiting ligand-independent endocytosis.
Development, 143(23) 4543-4553 (2016)
Shradha Das
Dissecting Crumbs to understand its function in epithelial development of Drosophila embryos
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2016)
Anne Morbach
The Role of Cdep in the Embryonic Morphogenesis of Drosophila melanogaster
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2016)
David Flores-Benitez, Elisabeth Knust
Dynamics of epithelial cell polarity in Drosophila: how to regulate the regulators?
Curr Opin Cell Biol, 42 13-21 (2016)
Giorgos Tsoumpekos
big bang, a novel regulator of tissue growth in Drosophila melanogaster
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2016)
Mihail Sarov, Christiane Barz, Helena Jambor, Marco Y Hein, Christopher Schmied, Dana Suchold, Bettina Stender, Stephan Janosch, Vinay Vikas Kj, R T Krishnan, Aishwarya Krishnamoorthy, Irene R S Ferreira, Radoslaw K Ejsmont, Katja Finkl, Susanne Hasse, Philipp Kämpfer, Nicole Plewka, Elisabeth Vinis, Siegfried Schloissnig, Elisabeth Knust, Volker Hartenstein, Matthias Mann, Mani Ramaswami, K VijayRaghavan, Pavel Tomancak, Frank Schnorrer
A genome-wide resource for the analysis of protein localisation in Drosophila.
Elife, 5 Art. No. e12068 (2016)


Ya-Huei Lin, Heather Currinn, Shirin Pocha, Alice Rothnie, Thomas Wassmer, Elisabeth Knust
AP-2-complex-mediated endocytosis of Drosophila Crumbs regulates polarity by antagonizing Stardust.
J Cell Sci, 128(24) 4538-4549 (2015)
Sarita Hebbar, Ishtapran Sahoo, Artur Matysik, Irene Argudo Garcia, Kathleen Amy Osborne, Cyrus Papan, Federico Torta, Pradeep Narayanaswamy, Xiu Hui Fun, Markus R Wenk, Andrej Shevchenko, Dominik Schwudke, Rachel Kraut
Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.
Sci Rep, 5 Art. No. 15926 (2015)
David Flores-Benitez, Elisabeth Knust
Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila.
Elife, 4 Art. No. e07398 (2015)
David J. Jörg, Luis G. Morelli, Daniele Soroldoni, Andrew C. Oates, Frank Jülicher
Continuum theory of gene expression waves during vertebrate segmentation
New J Phys, 17 Art. No. 093042 (2015)
Ya-Huei Lin
The AP2 complex regulates epithelial polarity via regulating Crumbs endocytosis
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2015)
David Flores-Benitez, Elisabeth Knust
Ménage a Trois to Form the Tricellular Junction.
Dev Cell, 33(5) 501-503 (2015)
Alexandra Kumichel, Katja Kapp, Elisabeth Knust
A Conserved Di-Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export.
Traffic, 16(6) 604-616 (2015)


Sarita Hebbar, Wolf Dieter Schulz, Ulrich Sauer, Dominik Schwudke
Laser capture microdissection coupled with on-column extraction LC-MS(n) enables lipidomics of fluorescently labeled Drosophila neurons.
Anal Chem, 86(11) 5345-5352 (2014)
Nagananda Gurudev, Michaela Yuan, Elisabeth Knust
chaoptin, prominin, eyes shut and crumbs form a genetic network controlling the apical compartment of Drosophila photoreceptor cells.
Biol Open, 3(5) 332-341 (2014)
Ruth Rincon-Heredia, David Flores-Benitez, Catalina Flores-Maldonado, José Bonilla-Delgado, Vicky García-Hernández, Odette Verdejo-Torres, Aida M Castillo, Isabel Larré, Augusto C Poot-Hernández, Martha Franco, Patricio Gariglio, José L Reyes, Rubén G Contreras
Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways.
Exp Cell Res, 320(1) 108-118 (2014)
Gerit Linneweber, Jake Jacobson, Karl Emanuel Busch, Bruno Hudry, Christo P. Christov, Dirk Dormann, Michaela Yuan, Tomoki Otani, Elisabeth Knust, Mario de Bono, Irene Miguel-Aliaga
Neuronal Control of Metabolism through Nutrient-Dependent Modulation of Tracheal Branching.
Cell, 156(1-2) 69-83 (2014)
Alexandra Kumichel, Elisabeth Knust
Apical localisation of crumbs in the boundary cells of the Drosophila hindgut is independent of its canonical interaction partner stardust.
PLoS ONE, 9(4) Art. No. e94038 (2014)


Sandra Soukup, Shirin Pocha, Michaela Yuan, Elisabeth Knust
DLin-7 Is Required in Postsynaptic Lamina Neurons to Prevent Light-Induced Photoreceptor Degeneration in Drosophila.
Curr Biol, 23(14) 1349-1354 (2013)
Shirin Pocha, Elisabeth Knust
Complexities of Crumbs function and regulation in tissue morphogenesis.
Curr Biol, 23(7) 289-293 (2013)
Sven Klose, David Flores-Benitez, Falko Riedel, Elisabeth Knust
Fosmid-based structure-function analysis reveals functionally distinct domains in the cytoplasmic domain of Drosophila crumbs.
G3 (Bethesda), 3(2) 153-165 (2013)
Nagananda Gurudev, Mareike Florek, Denis Corbeil, Elisabeth Knust
Prominent role of prominin in the retina.
Adv Exp Med Biol, 777 55-71 (2013)
Marta Luz, Elisabeth Knust
Fluorescently tagged Lin7c is a dynamic marker for polarity maturation in the zebrafish retinal epithelium.
Biol Open, 2(9) 867-871 (2013)
Joao Firmino, Jean-Yves Tinevez, Elisabeth Knust
Crumbs affects protein dynamics in anterior regions of the developing Drosophila embryo.
PLoS ONE, 8(3) Art. No. e58839 (2013)
Monalisa Mishra, Elisabeth Knust
Analysis of the Drosophila compound eye with light and electron microscopy.
Methods Mol Biol, 935 161-182 (2013)


Monalisa Mishra, Michaela Rentsch, Elisabeth Knust
Crumbs regulates polarity and prevents light-induced degeneration of the simple eyes of Drosophila, the ocelli
Eur J Cell Biol, 91(9) 706-716 (2012)
Katja Kapp, Johannes Siemens, Hans-Ulrich Häring, Reiner Lammers
Proteolytic processing of the protein tyrosine phosphatase α extracellular domain is mediated by ADAM17/TACE.
Eur J Cell Biol, 91(9) 687-693 (2012)


Nadine Muschalik, Elisabeth Knust
Increased levels of the cytoplasmic domain of Crumbs repolarise developing Drosophila photoreceptors
J Cell Sci, 124(21) 3715-3725 (2011)
Shirin Pocha, Anna Shevchenko, Elisabeth Knust
Crumbs regulates rhodopsin transport by interacting with and stabilizing myosin V
J Cell Biol, 195(5) 827-838 (2011)
Sven Klose
Investigation of the signal peptide and establishment of a novel structure-function analysis of crumbs in drosophila melanogaster
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2011)
Shirin Pocha, Thomas Wassmer, Christian Niehage, Bernard Hoflack, Elisabeth Knust
Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs
Curr Biol, 21(13) 1111-1117 (2011)
Goran Stjepanovic, Katja Kapp, Gert Bange, Christian Graf, Richard Parlitz, Klemens Wild, Matthias P. Mayer, Irmgard Sinning
Lipids trigger a conformational switch that regulates signal recognition particle (SRP)-mediated protein targeting.
J Biol Chem, 286(26) 23489-23497 (2011)
Elisabeth Knust
An interview with Elisabeth Knust: President of the German Society for Developmental Biology
Development, 138(12) 2399-2400 (2011)


Natalia Bulgakova, Michaela Rentsch, Elisabeth Knust
Antagonistic functions of two stardust isoforms in Drosophila photoreceptor cells.
Mol Biol Cell, 21(22) 3915-3925 (2010)
Annett Kilic, Sven Klose, Bernhard Dobberstein, Elisabeth Knust, Katja Kapp
The Drosophila Crumbs signal peptide is unusually long and is a substrate for signal peptide peptidase.
Eur J Cell Biol, 89(6) 449-461 (2010)
André Bachmann, Oliver Kobler, Robert J Kittel, Carolin Wichmann, Jimena Sierralta, Stephan J Sigrist, Eckart D Gundelfinger, Elisabeth Knust, Ulrich Thomas
A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.
J Neurosci, 30(17) 5811-5824 (2010)
Nadine Muschalik
Epithelial cell polarity and photoreceptor morphogensis in Drosophila
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2010)


Mélisande Richard, Nadine Muschalik, Ferdi Grawe, Susann Ozüyaman, Elisabeth Knust
A role for the extracellular domain of Crumbs in morphogenesis of Drosophila photoreceptor cells.
Eur J Cell Biol, 88(12) 765-777 (2009)
Natalia Bulgakova, Elisabeth Knust
The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
J Cell Sci, 122(Pt 15) 2587-2596 (2009)
Kyra Campbell, Elisabeth Knust, Helen Skaer
Crumbs stabilises epithelial polarity during tissue remodelling.
J Cell Sci, 122(Pt 15) 2604-2612 (2009)
Elisabeth Knust, Rainer Hertel
Jose-Antonio Campos-Ortega (1940-2004) and his scientific work - a personal perspective.
Int J Dev Biol, 53(8-10) 1193-1203 (2009)
Ines Kock, Natalia Bulgakova, Elisabeth Knust, Irmgard Sinning, Valérie Panneels
Targeting of Drosophila rhodopsin requires helix 8 but not the distal C-terminus.
PLoS ONE, 4(7) Art. No. e6101 (2009)


Natalia Bulgakova, Ozlem Kempkens, Elisabeth Knust
Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila.
J Cell Sci, 121(Pt 12) 2018-2026 (2008)
André Bachmann, Ferdi Grawe, Kevin Johnson, Elisabeth Knust
Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration.
Eur J Cell Biol, 87(3) 123-136 (2008)
André Bachmann, Elisabeth Knust
The use of P-Element Transposons to Generate Transgenic Flies
In: Drosophila: Methods and Protocols. (Eds.) Christian Dahmann Methods in molecular biology, 420.,Totowa, USA,Humana Press (2008),61-77 Ch. 4
André Bachmann, Margarete Draga, Ferdi Grawe, Elisabeth Knust
On the role of the MAGUK proteins encoded by Drosophila varicose during embryonic and postembryonic development.
BMC Dev Biol, 8 55-55 (2008)
Elisabeth Knust, Wilfried Janning
Genetik : allgemeine Genetik, molekulare Genetik, Entwicklungsgenetik
Stuttgart, Thieme (2008), 515 S.


Elisabeth Knust
Photoreceptor morphogenesis and retinal degeneration: lessons from Drosophila.
Curr Opin Neurobiol, 17(5) 541-547 (2007)
Sandra Berger, Natalia Bulgakova, Ferdi Grawe, Kevin Johnson, Elisabeth Knust
Unraveling the genetic complexity of Drosophila stardust during photoreceptor morphogenesis and prevention of light-induced degeneration.
Genetics, 176(4) 2189-2200 (2007)
Elisabeth Knust, Wieland B. Huttner
Cell polarity from cell division.
Dev Cell, 12(5) 664-666 (2007)
Isabel Wasserscheid, Ulrich Thomas, Elisabeth Knust
Isoform-specific interaction of Flamingo/Starry Night with excess Bazooka affects planar cell polarity in the Drosophila wing.
Dev Dyn, 236(4) 1064-1071 (2007)


Kevin Johnson, Ferdi Grawe, Nicola Grzeschik, Elisabeth Knust
Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration.
Curr Biol, 12(19) 1675-1680 (2002)


André Bachmann, M Schneider, Eva Theilenberg, Ferdi Grawe, Elisabeth Knust
Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity.
Nature, 414(6864) 638-643 (2001)