Research Groups

* joined first author # joined corresponding author

2021

Sarita Hebbar, Elisabeth Knust
Reactive oxygen species (ROS) constitute an additional player in regulating epithelial development.
Bioessays, 43(8) Art. No. 2100096 (2021)
Open Access   DOI
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Sarita Hebbar✳︎, Malte Lehmann✳︎, Sarah Behrens, Catrin Hälsig, Weihua Leng, Michaela Yuan, Sylke Winkler, Elisabeth Knust
Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila.
Biol Open, 10(1) Art. No. bio052332 (2021)
Open Access   DOI
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Srija Bhagavatula
First person - Srija Bhagavatula.
J Cell Sci, 134(2) Art. No. jcs258327 (2021)
DOI
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Sarita Hebbar, Malte Lehmann
First person - Sarita Hebbar and Malte Lehmann.
Biol Open, 10(1) Art. No. bio058519 (2021)
Open Access   DOI

2020

Srija Bhagavatula, Elisabeth Knust
A putative stem-loop structure in Drosophila crumbs is required for mRNA localisation in epithelia and germline cells.
J Cell Sci, 134(2) Art. No. jcs236497 (2020)
Open Access   DOI
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Sarita Hebbar, Kai Schuhmann, Andrej Shevchenko, Elisabeth Knust
Hydroxylated sphingolipid biosynthesis regulates photoreceptor apical domain morphogenesis.
J Cell Biol, 219(12) Art. No. e201911100 (2020)
DOI
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Bharath Kumar Raghuraman✳︎, Sarita Hebbar✳︎, Mukesh Kumar, HongKee Moon, Ian Henry, Elisabeth Knust, Andrej Shevchenko
Absolute Quantification of Proteins in the Eye of Drosophila melanogaster.
Proteomics, 20(23) Art. No. e1900049 (2020)
Open Access   DOI
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Satu Kujawski✳︎, Catia Crespo✳︎, Marta Luz, Michaela Yuan, Sylke Winkler, Elisabeth Knust
Loss of Crb2b-lf leads to anterior segment defects in old zebrafish.
Biol Open, 9(2) Art. No. bio.047555 (2020)
Open Access   DOI

2019

Johanna Lattner, Weihua Leng, Elisabeth Knust, Marko Brankatschk#, David Flores-Benitez#
Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P2 in Drosophila.
Elife, 8 Art. No. e50900 (2019)
Open Access   DOI
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Elisabeth Knust#, Kai Simons#
Suzanne Eaton (1959-2019): A pioneer in quantitative tissue morphogenesis.
J Cell Biol, 218(9) 2819-2821 (2019)
DOI
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Volker Hartenstein, Michaela Yuan, Amelia Younossi-Hartenstein, Aanavi Karandikar, F Javier Bernardo-Garcia, Simon Sprecher, Elisabeth Knust
Serial electron microscopic reconstruction of the drosophila larval eye: Photoreceptors with a rudimentary rhabdomere of microvillar-like processes.
Dev Biol, 453(1) 56-67 (2019)
DOI
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Anna Bajur, K Venkatesan Iyer, Elisabeth Knust
Cytocortex-dependent dynamics of Drosophila Crumbs controls junctional stability and tension during germ band retraction.
J Cell Sci, 132(15) Art. No. jcs228338 (2019)
DOI
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Kassiani Skouloudaki#, Ioannis Christodoulou, Dilan Khalili, Vasilios Tsarouhas, Christos Samakovlis, Pavel Tomancak, Elisabeth Knust#, Dimitrios Papadopoulos#
Yorkie controls tube length and apical barrier integrity during airway development.
J Cell Biol, 218(8) 2762-2781 (2019)
DOI
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Satu Kujawski, Mahendra Sonawane, Elisabeth Knust
penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina.
Biol Open, 8(4) Art. No. bio041830 (2019)
Open Access   DOI
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Sara Caviglia, David Flores-Benitez, Johanna Lattner, Stefan Luschnig, Marko Brankatschk
Rabs on the fly: Functions of Rab GTPases during development.
Small GTPases, 10(2) 89-98 (2019)
Open Access   DOI
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Dimitrios Papadopoulos#, Kassiani Skouloudaki, Ylva Engström, Lars Terenius, Rudolf Rigler, Christoph Zechner, Vladana Vukojević, Pavel Tomancak#
Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch.
Development, 146(12) Art. No. dev168179 (2019)
Open Access   DOI
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Kassiani Skouloudaki✳︎#, Dimitrios Papadopoulos✳︎, Pavel Tomancak, Elisabeth Knust#
The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation.
PLoS Genet, 15(1) Art. No. e1007852 (2019)
Open Access   DOI
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Joan Sim, Kathleen Amy Osborne, Irene Argudo García, Artur Matysik, Rachel Kraut
The BEACH Domain Is Critical for Blue Cheese Function in a Spatial and Epistatic Autophagy Hierarchy.
Front Cell Dev Biol, 7 Art. No. 129 (2019)
Open Access   DOI
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Sarita Hebbar, Elisabeth Knust, Guillaume Thibault#, Rachel Kraut#
Editorial: Connections to Membrane Trafficking Where You Least Expect Them: Diseases, Dynamics, Diet and Distance.
Front Cell Dev Biol, 7 Art. No. 327 (2019)
Open Access   DOI
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Malte Lehmann, Elisabeth Knust, Sarita Hebbar
Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa.
Methods Mol Biol, 1834 221-249 (2019)
DOI
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Rachel Kraut, Elisabeth Knust
Changes in endolysosomal organization define a pre-degenerative state in the crumbs mutant Drosophila retina.
PLoS ONE, 14(12) Art. No. e220220 (2019)
Open Access   DOI
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Monalisa Mishra, Elisabeth Knust
Analysis of the Drosophila Compound Eye with Light and Electron Microscopy.
Methods Mol Biol, 1834 345-364 (2019)
DOI

2018

Catia Crespo, Elisabeth Knust
Characterisation of maturation of photoreceptor cell subtypes during zebrafish retinal development.
Biol Open, 7(11) Art. No. bio036632 (2018)
Open Access   DOI
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Catia Crespo, Daniele Soroldoni, Elisabeth Knust
A novel transgenic zebrafish line for red opsin expression in outer segments of photoreceptor cells.
Dev Dyn, 247(7) 951-959 (2018)
Open Access   DOI
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Giorgos Tsoumpekos, Linda Nemetschke, Elisabeth Knust
Drosophila Big bang regulates the apical cytocortex and wing growth through junctional tension.
J Cell Biol, 217(3) 1033-1045 (2018)
DOI
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Shradha Das, Elisabeth Knust
A dual role of the extracellular domain of DrosophilaCrumbs for morphogenesis of the embryonic neuroectoderm.
Biol Open, 7(1) Art. No. bio031435 (2018)
Open Access   DOI
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Alejandro Vignoni, Anna Bajur, Elisabeth Knust, Ivo F. Sbalzarini
Multi-objective identification from fluorescence recovery after photobleaching experiments: Understanding morphogenetic regulation of epithelial polarity
IFAC-PapersOnLine, 51(19) 8-11 (2018)
Open Access  

2017

Arturo Raya-Sandino, Alejandro Castillo-Kauil, Alaide Domínguez-Calderón, Lourdes Alarcón, David Flores-Benitez, Francisco Cuellar-Perez, Bruno López-Bayghen, Bibiana Chávez-Munguía, José Vázquez-Prado, Lorenza González-Mariscal
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
Biochim Biophys Acta, 1864(10) 1714-1733 (2017)
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Shradha Das, Elisabeth Knust
Stardust, the Janus-faced partner of Crumbs.
J Cell Biol, 216(5) 1219-1221 (2017)
DOI
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Stephanie Spannl✳︎, Alexandra Kumichel✳︎, Sarita Hebbar, Katja Kapp, Marcos Gonzalez-Gaitan, Sylke Winkler, Rosana Blawid, Gregor Jessberger, Elisabeth Knust
The Crumbs_C isoform of Drosophila shows tissue- and stage-specific expression and prevents light-dependent retinal degeneration.
Biol Open, 6(2) 165-175 (2017)
Open Access   PDF    DOI

2016

Linda Nemetschke, Elisabeth Knust
Drosophila Crumbs prevents ectopic Notch activation in developing wings by inhibiting ligand-independent endocytosis.
Development, 143(23) 4543-4553 (2016)
DOI
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Shradha Das
Dissecting Crumbs to understand its function in epithelial development of Drosophila embryos
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2016)
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Anne Morbach
The Role of Cdep in the Embryonic Morphogenesis of Drosophila melanogaster
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2016)
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David Flores-Benitez, Elisabeth Knust
Dynamics of epithelial cell polarity in Drosophila: how to regulate the regulators?
Curr Opin Cell Biol, 42 13-21 (2016)
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Giorgos Tsoumpekos
big bang, a novel regulator of tissue growth in Drosophila melanogaster
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2016)
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Mihail Sarov#, Christiane Barz, Helena Jambor, Marco Y Hein, Christopher Schmied, Dana Suchold, Bettina Stender, Stephan Janosch, Vinay Vikas Kj, R T Krishnan, Aishwarya Krishnamoorthy, Irene R S Ferreira, Radoslaw K Ejsmont, Katja Finkl, Susanne Hasse, Philipp Kämpfer, Nicole Plewka, Elisabeth Vinis, Siegfried Schloissnig, Elisabeth Knust, Volker Hartenstein, Matthias Mann, Mani Ramaswami, K VijayRaghavan, Pavel Tomancak#, Frank Schnorrer#
A genome-wide resource for the analysis of protein localisation in Drosophila.
Elife, 5 Art. No. e12068 (2016)
Open Access   PDF    DOI

2015

Ya-Huei Lin, Heather Currinn, Shirin Pocha, Alice Rothnie, Thomas Wassmer, Elisabeth Knust
AP-2-complex-mediated endocytosis of Drosophila Crumbs regulates polarity by antagonizing Stardust.
J Cell Sci, 128(24) 4538-4549 (2015)
DOI
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Sarita Hebbar, Ishtapran Sahoo, Artur Matysik, Irene Argudo Garcia, Kathleen Amy Osborne, Cyrus Papan, Federico Torta, Pradeep Narayanaswamy, Xiu Hui Fun, Markus R Wenk, Andrej Shevchenko, Dominik Schwudke, Rachel Kraut
Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.
Sci Rep, 5 Art. No. 15926 (2015)
Open Access   PDF    DOI
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David Flores-Benitez, Elisabeth Knust
Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila.
Elife, 4 Art. No. e07398 (2015)
Open Access   PDF    DOI
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David J. Jörg, Luis G. Morelli, Daniele Soroldoni, Andrew C. Oates, Frank Jülicher
Continuum theory of gene expression waves during vertebrate segmentation
New J Phys, 17 Art. No. 093042 (2015)
Open Access   PDF    DOI
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Ya-Huei Lin
The AP2 complex regulates epithelial polarity via regulating Crumbs endocytosis
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2015)
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David Flores-Benitez, Elisabeth Knust
Ménage a Trois to Form the Tricellular Junction.
Dev Cell, 33(5) 501-503 (2015)
DOI
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Alexandra Kumichel, Katja Kapp, Elisabeth Knust
A Conserved Di-Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export.
Traffic, 16(6) 604-616 (2015)
DOI

2014

Sarita Hebbar, Wolf Dieter Schulz, Ulrich Sauer, Dominik Schwudke
Laser capture microdissection coupled with on-column extraction LC-MS(n) enables lipidomics of fluorescently labeled Drosophila neurons.
Anal Chem, 86(11) 5345-5352 (2014)
Open Access   DOI
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Nagananda Gurudev, Michaela Yuan, Elisabeth Knust
chaoptin, prominin, eyes shut and crumbs form a genetic network controlling the apical compartment of Drosophila photoreceptor cells.
Biol Open, 3(5) 332-341 (2014)
Open Access   PDF    DOI
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Ruth Rincon-Heredia, David Flores-Benitez, Catalina Flores-Maldonado, José Bonilla-Delgado, Vicky García-Hernández, Odette Verdejo-Torres, Aida M Castillo, Isabel Larré, Augusto C Poot-Hernández, Martha Franco, Patricio Gariglio, José L Reyes, Rubén G Contreras
Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways.
Exp Cell Res, 320(1) 108-118 (2014)
DOI
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Gerit Linneweber, Jake Jacobson, Karl Emanuel Busch, Bruno Hudry, Christo P. Christov, Dirk Dormann, Michaela Yuan, Tomoki Otani, Elisabeth Knust, Mario de Bono, Irene Miguel-Aliaga
Neuronal Control of Metabolism through Nutrient-Dependent Modulation of Tracheal Branching.
Cell, 156(1-2) 69-83 (2014)
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Alexandra Kumichel, Elisabeth Knust
Apical localisation of crumbs in the boundary cells of the Drosophila hindgut is independent of its canonical interaction partner stardust.
PLoS ONE, 9(4) Art. No. e94038 (2014)
Open Access   PDF    DOI

2013

Sandra Soukup, Shirin Pocha, Michaela Yuan, Elisabeth Knust
DLin-7 Is Required in Postsynaptic Lamina Neurons to Prevent Light-Induced Photoreceptor Degeneration in Drosophila.
Curr Biol, 23(14) 1349-1354 (2013)
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Shirin Pocha#, Elisabeth Knust#
Complexities of Crumbs function and regulation in tissue morphogenesis.
Curr Biol, 23(7) 289-293 (2013)
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Sven Klose, David Flores-Benitez, Falko Riedel, Elisabeth Knust
Fosmid-based structure-function analysis reveals functionally distinct domains in the cytoplasmic domain of Drosophila crumbs.
G3 (Bethesda), 3(2) 153-165 (2013)
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Nagananda Gurudev, Mareike Florek, Denis Corbeil, Elisabeth Knust
Prominent role of prominin in the retina.
Adv Exp Med Biol, 777 55-71 (2013)
DOI
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Marta Luz, Elisabeth Knust
Fluorescently tagged Lin7c is a dynamic marker for polarity maturation in the zebrafish retinal epithelium.
Biol Open, 2(9) 867-871 (2013)
Open Access   DOI
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Joao Firmino, Jean-Yves Tinevez, Elisabeth Knust
Crumbs affects protein dynamics in anterior regions of the developing Drosophila embryo.
PLoS ONE, 8(3) Art. No. e58839 (2013)
Open Access   PDF    DOI
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Monalisa Mishra, Elisabeth Knust
Analysis of the Drosophila compound eye with light and electron microscopy.
Methods Mol Biol, 935 161-182 (2013)
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2012

Monalisa Mishra, Michaela Rentsch, Elisabeth Knust
Crumbs regulates polarity and prevents light-induced degeneration of the simple eyes of Drosophila, the ocelli
Eur J Cell Biol, 91(9) 706-716 (2012)
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Katja Kapp✳︎, Johannes Siemens✳︎, Hans-Ulrich Häring, Reiner Lammers
Proteolytic processing of the protein tyrosine phosphatase α extracellular domain is mediated by ADAM17/TACE.
Eur J Cell Biol, 91(9) 687-693 (2012)
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2011

Nadine Muschalik, Elisabeth Knust
Increased levels of the cytoplasmic domain of Crumbs repolarise developing Drosophila photoreceptors
J Cell Sci, 124(21) 3715-3725 (2011)
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Shirin Pocha, Anna Shevchenko, Elisabeth Knust
Crumbs regulates rhodopsin transport by interacting with and stabilizing myosin V
J Cell Biol, 195(5) 827-838 (2011)
PDF    DOI
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Sven Klose
Investigation of the signal peptide and establishment of a novel structure-function analysis of crumbs in drosophila melanogaster
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2011)
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Shirin Pocha, Thomas Wassmer#, Christian Niehage, Bernard Hoflack, Elisabeth Knust#
Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs
Curr Biol, 21(13) 1111-1117 (2011)
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Goran Stjepanovic, Katja Kapp, Gert Bange, Christian Graf, Richard Parlitz, Klemens Wild, Matthias P. Mayer, Irmgard Sinning
Lipids trigger a conformational switch that regulates signal recognition particle (SRP)-mediated protein targeting.
J Biol Chem, 286(26) 23489-23497 (2011)
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Elisabeth Knust
An interview with Elisabeth Knust: President of the German Society for Developmental Biology
Development, 138(12) 2399-2400 (2011)
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2010

Natalia Bulgakova, Michaela Rentsch, Elisabeth Knust
Antagonistic functions of two stardust isoforms in Drosophila photoreceptor cells.
Mol Biol Cell, 21(22) 3915-3925 (2010)
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Annett Kilic✳︎, Sven Klose✳︎, Bernhard Dobberstein, Elisabeth Knust, Katja Kapp
The Drosophila Crumbs signal peptide is unusually long and is a substrate for signal peptide peptidase.
Eur J Cell Biol, 89(6) 449-461 (2010)
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André Bachmann✳︎, Oliver Kobler✳︎, Robert J Kittel, Carolin Wichmann, Jimena Sierralta, Stephan J Sigrist, Eckart D Gundelfinger, Elisabeth Knust, Ulrich Thomas
A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.
J Neurosci, 30(17) 5811-5824 (2010)
PDF    DOI
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Nadine Muschalik
Epithelial cell polarity and photoreceptor morphogensis in Drosophila
Ph.D. Thesis,Technische Universität Dresden, Dresden, Germany (2010)

2009

Mélisande Richard✳︎, Nadine Muschalik✳︎, Ferdi Grawe, Susann Ozüyaman, Elisabeth Knust
A role for the extracellular domain of Crumbs in morphogenesis of Drosophila photoreceptor cells.
Eur J Cell Biol, 88(12) 765-777 (2009)
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Natalia Bulgakova, Elisabeth Knust
The Crumbs complex: from epithelial-cell polarity to retinal degeneration.
J Cell Sci, 122(Pt 15) 2587-2596 (2009)
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Kyra Campbell, Elisabeth Knust, Helen Skaer
Crumbs stabilises epithelial polarity during tissue remodelling.
J Cell Sci, 122(Pt 15) 2604-2612 (2009)
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Elisabeth Knust, Rainer Hertel
Jose-Antonio Campos-Ortega (1940-2004) and his scientific work - a personal perspective.
Int J Dev Biol, 53(8-10) 1193-1203 (2009)
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Ines Kock, Natalia Bulgakova, Elisabeth Knust, Irmgard Sinning, Valérie Panneels
Targeting of Drosophila rhodopsin requires helix 8 but not the distal C-terminus.
PLoS ONE, 4(7) Art. No. e6101 (2009)
Open Access   PDF    DOI

2008

Natalia Bulgakova, Ozlem Kempkens, Elisabeth Knust
Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila.
J Cell Sci, 121(Pt 12) 2018-2026 (2008)
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André Bachmann, Ferdi Grawe, Kevin Johnson, Elisabeth Knust
Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration.
Eur J Cell Biol, 87(3) 123-136 (2008)
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André Bachmann, Elisabeth Knust
The use of P-Element Transposons to Generate Transgenic Flies
In: Drosophila: Methods and Protocols. (Eds.) Christian Dahmann Methods in molecular biology, 420.,Totowa, USA,Humana Press (2008),61-77 Ch. 4
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André Bachmann, Margarete Draga, Ferdi Grawe, Elisabeth Knust
On the role of the MAGUK proteins encoded by Drosophila varicose during embryonic and postembryonic development.
BMC Dev Biol, 8 55-55 (2008)
Open Access   PDF    DOI
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Elisabeth Knust, Wilfried Janning
Genetik : allgemeine Genetik, molekulare Genetik, Entwicklungsgenetik
Stuttgart, Thieme (2008), 515 S.

2007

Elisabeth Knust
Photoreceptor morphogenesis and retinal degeneration: lessons from Drosophila.
Curr Opin Neurobiol, 17(5) 541-547 (2007)
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Sandra Berger✳︎, Natalia Bulgakova✳︎, Ferdi Grawe, Kevin Johnson, Elisabeth Knust
Unraveling the genetic complexity of Drosophila stardust during photoreceptor morphogenesis and prevention of light-induced degeneration.
Genetics, 176(4) 2189-2200 (2007)
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Elisabeth Knust, Wieland B. Huttner
Cell polarity from cell division.
Dev Cell, 12(5) 664-666 (2007)
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Isabel Wasserscheid, Ulrich Thomas, Elisabeth Knust
Isoform-specific interaction of Flamingo/Starry Night with excess Bazooka affects planar cell polarity in the Drosophila wing.
Dev Dyn, 236(4) 1064-1071 (2007)
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2002

Kevin Johnson, Ferdi Grawe, Nicola Grzeschik, Elisabeth Knust
Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration.
Curr Biol, 12(19) 1675-1680 (2002)
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2001

André Bachmann, M Schneider, Eva Theilenberg, Ferdi Grawe, Elisabeth Knust
Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity.
Nature, 414(6864) 638-643 (2001)
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