Research Groups

Intensity-independent noise filtering in shotgun FT MS and FT MS/MS spectra

Shotgun lipidomics relies on the direct infusion of total lipid extracts into a high resolution tandem mass spectrometer. A single shotgun analysis produces several hundred of densely populated FT MS and FT MS/MS spectra that comprise thousands of peaks although a very small percentage of those belong to lipids. We developed the software PeakStrainer DOI 10.1021/acs.analchem.7b00794 that eliminates more than 95% of signals detectable in shotgun spectra without compromising the accuracy and scope of lipid identification and quantification.

© 2017 American Chemical Society

Jacobo Miranda