We seek a highly communicative, motivated, and experienced specialist to work and coordinate operations in our state-of-the-art Electron Microscopy Facility. This role is pivotal in supporting cutting-edge research within the institute at both tissue and molecular scale. The Electron Microscopy Facility is part of our comprehensive suite of scientific core facilities and is responsible for providing a comprehensive range of services enabling high resolution imaging from the molecular scale (Cryo-EM) to large volume imaging. The facility is equipped with state-of-the-art electron microscopes (https://www.mpi-cbg.de/research/scientific-cores-support/scientific-services/electron-microscopy), enabling detailed structural analyses that drive discoveries in cell biology.

Role and Responsibilities:

We seek candidates at a senior level to coordinate and conduct EM projects and ideally lead the facility immediately or after an orientation phase.

• Manage the facility, including facility budget oversight, operational planning, and staff management. The degree of leadership responsibility will depend on seniority and interest.
• Provide guidance and insights into biology to the Electron Microscopy Facility team, ensuring state-of-the-art services for sample preparation, imaging, and data.
• Perform experiments and provide expert guidance and training to users in electron microscopy techniques, including transmission electron microscopy (TEM) and scanning electron microscopy (SEM).
• Contribute to analysis and interpretation of the acquired data.
• Collaborate with interdisciplinary research teams to develop and optimize cutting-edge electron microscopy methodologies (CLEM, Cryo-EM, FIB-SEM).
• contribute to maintaining and expanding the facility's equipment, ensuring peak operational efficiency and staying abreast of technological advancements.
• Drive innovation in electron microscopy applications, bridging molecular, cellular, and tissue scales to support the institute’s research goals.
• Engage in active scientific dialogue within the institute and with external collaborators, fostering a vibrant research community.
• Promote networks with other national and international Facilities and Units.

Required Qualifications:

• PhD in Biology, Biophysics, Biomedical Sciences or a related field, with a strong experience in electron microscopy
• demonstrated expertise in advanced electron microscopy techniques, including sample preparation, imaging, and data interpretation. Our emphasis is on Large Volume Electron Microscopy but applicants with experience in Cryo-Electron Microscopy (Cryo-EM) and/or Correlative Light and Cryo-Electron Microscopy (CLEM) are strongly encouraged to apply if they are willing to build skills in Large Volume Electron Microscopy
• a proven track record of research achievements, including publications in high-impact journals
• strong collaborative and communication skills, with a commitment to fostering interdisciplinary research
• creativity and innovation in developing new microscopy techniques and applications
• experience in technology development and implementation in the realm of electron microscopy is highly valued
• as we work with different tools across multiple areas, you must be comfortable navigating challenging environments and solving complex problems
• fluency in English, the working language of the MPI-CBG

Desired scientific experience and experimental skills:

• preferably experience in a core facility
• CLEM (room temperature and preferably cryo)
• freezing techniques (HPF and plungefreezing)
• chemical fixation, freeze substitution, ultramicrotomy (room temperature and preferably cryo)
• TEM tomography (room temperature and preferably cryo)
• standard SEM, Serial Block-Face SEM, and FIB/SEM (room temperature and preferably cryo)
• preferably experience in single particle analysis

We Offer:

• a stimulating, interdisciplinary research environment at a leading international research institute
• access to state-of-the-art facilities and equipment
• opportunities for professional development and career advancement
• a collaborative, collegial atmosphere with a dynamic, supportive research community
• a competitive salary and benefits package commensurate with experience. Remuneration is in accordance with TVöD Bund (salary agreement for public service)
• social benefits of the public service (company pension scheme (VBL), annual special payment, subsidy for VVO job ticket, group accident insurance)
• active measures to promote company health management and work-life balance

The full-time position (39 hours/week) is available immediately. The initial contract is for 2 years with the expectation of prolongation contingent on the agreement of both parties.

How to Apply:

Please submit your application, including the following documents:

1. A cover letter detailing your qualifications and research interests.
2. A curriculum vitae (CV) with a list of publications.
3. A brief statement (1-2 pages) of your vision for the Electron Microscopy Facility and how you would contribute to the MPI-CBG research community.
4. Contact information for at least three professional references.

Applications should be submitted electronically as a single PDF file via our online application system stating 2024-EMSpecialist-4110 by 16 August 2024.

We look forward to receiving your application.

Initial questions about the position can be addressed to Jussi Helppi, Services & Facilities Representative, via jhelppi(at)mpi-cbg.de or Anne Grapin-Botton, Managing Director, via botton(at)mpi-cbg.de. Questions regarding the application process, contract, compensation or benefits may be addressed to hr(at)mpi-cbg.de. For further information about the MPI-CBG and the CSBD see www.csbdresden.de, www.mpi-cbg.de.

Max Planck Institute of Molecular Cell Biology and Genetics
Pfotenhauerstr. 108, 01307 Dresden, Germany
http://www.mpi-cbg.de

• The Max Planck Society strives for gender equality and diversity. We welcome applications from all backgrounds, regardless of gender, nationality, ethnicity, sexual orientation, religion, age, and other components of identity.
• The Max Planck Society specifically aims to increase the proportion of women in the areas in which they are underrepresented. We therefore explicitly invite women to apply.
• The Max Planck Society is further committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
• The Max Planck Society supports the compatibility of family and career and is certified according to the "berufundfamilie" (“job and family”) audit.
• When you submit a job application to MPI-CBG, you are transmitting personal data. Please refer to our privacy notice for information on how we collect and process personal data in accordance with Art. 13 of the Datenschutz-Grundverordnung. By submitting your application you confirm that you have taken note of the information in our privacy notice.

Our research team is highly interdisciplinary, international, and collaborative; English is the primary working language in both the Huch lab and the institute.

Job description

We aim to identify the molecular and cellular mechanisms that regulate tissue repair and the emergence of diseases from their deregulation, with a particular focus in fibrosis and cancer. At the molecular level, we found that massive epigenetic and transcriptional reprogramming occurs in adult tissues when they exit quiescence and enter the regenerative state (Aloia et al., Nature Cell Biology 2019). We are now exploring other layers of gene regulation, including metabolic rewiring, to gain a detailed molecular understanding of the transition from quiescence. At the cellular level, we also described that, paradoxically, the cell-cell interactions between stromal and epithelial cells can either promote regeneration or maintain quiescence, depending on the number of direct cell-cell contacts between both populations (Cordero-Espinoza et al., Cell Stem Cell 2021). We now aim to investigate the direct players involved in this process by studying cell adhesion and cell matrix interactions.

Within this context, we are seeking talented postdoctoral researchers interested in learning and understanding the intricacies of tissue dynamics and organogenesis when challenged, the mechanisms that enable returning to homeostasis, and/or the mechanisms that trigger disease.

Your qualifications

• Doctoral degree
• Documented experience in molecular, cell culture and in vivo techniques (e.g., tissue culture, mouse models, FACS, genome-wide and omics-approaches)
• Research background in epigenetics and metabolism, as well as cell biology, cell-matrix or cell-adhesion is highly advantageous
• Excellent communication and data presentation skills
• Excellent command of the English language

Our offer

The full-time position is available immediately for an initial period of 2 years with the possibility of extension. Salary and social benefits will be in accordance with the collective agreement of the German public service (TVöD, EG13 100%). Starting gross salary would therefore range from 58 – 74K annually, depending on qualifications and experience.

For further details on the open position, please contact Dr. Lisa Johnsen via johnsen(at)mpi-cbg.de or telephone +49 (0)351 210 2136. For questions about the contract or compensation, please contact Brian von Rueden, Head of Human Resources, via hr@mpi-cbg.de.

Application materials should include:

• cover letter indicating previous research accomplishments and motivation to apply
• CV
• names of potential references/two letters of recommendation

Please submit your application by 31.07.2024 stating the Code 2024-Postdoc-TissueMechanics-1110 via our online system: https://recruitingapp-2443.umantis.com/Vacancies/590/Application/CheckLogin/2?lang=eng.

Max Planck Institute of Molecular Cell Biology and Genetics
Pfotenhauerstr. 108
01307 Dresden, Germany

• The Max Planck Society strives for gender equality and diversity. We welcome applications from all backgrounds, regardless of gender, nationality, ethnicity, sexual orientation, religion, age, and other components of identity.
• The Max Planck Society specifically aims to increase the proportion of women in the areas in which they are underrepresented. We therefore explicitly invite women to apply.
• The Max Planck Society is further committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
• The Max Planck Society supports the compatibility of family and career and is certified according to the "berufundfamilie" (“job and family”) audit.
• When you submit a job application to MPI-CBG, you are transmitting personal data. Please refer to our privancy policy for information on how we collect and process personal data in accordance with Art. 13 of the Datenschutz-Grundverordnung. By submitting your application, you confirm that you have taken note of the information in our privacy notice.

The Rodenfels group pursues interdisciplinary experimental research at the intersection of cell and developmental biology, metabolism, biochemistry, and physical bioenergetics. We aim to understand how flows of energy, matter, and cellular metabolism shape the behavior of out-of-equilibrium biological systems such as biochemical networks, cells, and developing organisms.

The lab uses calorimetry to quantify the energy exchanged in heat between biological systems and their environment, combined with quantitative (live) imaging, metabolomics, biochemistry, and perturbations. Together, these approaches open up many exciting questions, excellent research opportunities, and freedom to shape a project (see opportunities). We aim to expand our team with molecular and biochemical scale expertise to study energetics and non-equilibrium behavior of biochemical oscillators such as the circadian clock. As a lab, we value enthusiasm, creativity, respect, trust, honesty, collegiality, rigor, humor, and fun in doing science together.

Your qualification:

We seek a highly motivated researcher with compatible values, good knowledge of English, an affinity for quantitative analysis, and the knowledge and expertise to complement our team from a molecular and biochemical perspective. Postdoc candidates should have a doctoral degree (Ph.D.) and at least one first-author publication. PhD candidates should have a Master of Science (M.Sc) in a relevant discipline. Research activities will involve molecular biology, biochemistry, protein purification, cell extracts, in-vitro reconstitutions, calorimetry, and bioenergetics of non-equilibrium systems. Professional and/or academic experience in related areas would be of advantage.

Our offer:

The full-time position is available immediately. Postdocs receive an initial two-year appointment with the possibility of an extension. Ph.D. students are awarded a four-year appointment after a successful evaluation by the International Max Planck Research School for Cell, Developmental, and Systems Biology (IMPRS-CellDevoSys). Salary and social benefits will be under the regulations of the German TVöD Bund (salary agreement for public service employees, up to level E13).

Application:

The application should include (i) a cover letter indicating the motivation to apply for this position, (ii) a CV, (iii) two letters of recommendation (these can also be emailed directly), or names of potential references, and (iv) a short statement of the candidate’s previous research accomplishments (<1 page). Please submit your application by 15.08.2024 stating the Code 2024-Postdoc-Energetics-2430 via our online system: https://recruitingapp-2443.umantis.com/Vacancies/589/Application/CheckLogin/2?lang=eng.

For informal inquiries about the position, please get in touch with Dr. Jonathan Rodenfels via email: rodenfels@mpi-cbg.de. For questions about the contract or compensation, please contact Brian von Rueden, Head of Human Resources, via hr(at)mpi-cbg.de.

Max Planck Institute of Molecular Cell Biology and Genetics
Pfotenhauerstr. 108
01307 Dresden, Germany
http://www.mpi-cbg.de
 

• The Max Planck Society strives for gender equality and diversity. We welcome applications from all backgrounds, regardless of gender, nationality, ethnicity, sexual orientation, religion, age, and other components of identity.
• The Max Planck Society specifically aims to increase the proportion of women in the areas in which they are underrepresented. We therefore explicitly invite women to apply.
• The Max Planck Society is further committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
• The Max Planck Society supports the compatibility of family and career and is certified according to the "berufundfamilie" (“job and family”) audit.
• When you submit a job application to MPI-CBG, you are transmitting personal data. Please refer to our privacy notice for information on how we collect and process personal data in accordance with Art. 13 of the Datenschutz-Grundverordnung. By submitting your application you confirm that you have taken note of the information in our privacy notice.

Job description
We are currently seeking a technician to join our collaborative project with Prof. Daniel Stange's research group at Technische Universität Dresden. In this role, you will closely collaborate with researchers from both teams.

Your responsibilities will include

• collection and preparation of primary and metastatic tissue from the gastrointestinal tract and liver
• conduct liver perfusion procedures
• generate organoids from these tissues, assisting in their expansion, and maintaining a biobank.
• perform standard molecular and cell biology techniques, such as qPCR, next-generation sequencing, immunohistochemistry (IHC), and immunofluorescence (IF), to characterize the organoids
• mouse work and handling
• liaise with surgery, pathology and molecular laboratories
• maintain the laboratory database of human tissue and organoid tissues 

As a technician, you will not only contribute to experiments but also handle various organizational and maintenance tasks within the groups. Furthermore, you will play a key role in coordinating patient follow-up.

Your qualifications

• training as a technical assistant (MTA/BTA/CTA) or equivalent qualification
• strong command of molecular and cellular biology techniques
• self-motivated and enthusiastic disposition
• strong organizational skills, demonstrating flexibility and reliability
• proven ability to work effectively in a team
• proficiency in both German and English languages
• experience in isolating, cultivating, and manipulating cell lines, primary cells, and organoids is advantageous
• proven ability to document and keep databases up to date is highly advantageous
• familiarity with laboratory animal handling is advantageous

Our offer
The full- or part-time position (min. 30 hours/week) is available immediately for an initial period of 2 years with the possibility of extension. Salary and social benefits will be in accordance with the regulations of the German TVöD Bund (salary agreement for public service employees). The MPI-CBG offers a JobTicket in collaboration with the VVO, as well as a broad network for career development and training opportunities through the Max Planck Society.

For further details on the open position please contact Dr. Lisa Johnsen via email johnsen(at)mpi-cbg.de or telephone +49 (0)351 210 2136.

Please send a one-page motivation letter, your CV, and a transcript of records by 16 August 2024 via our online application system stating Code 2024-Technician-MolecularBiology-1110. Applications will be assessed on a rolling basis.
 

Max Planck Institute of Molecular Cell Biology and Genetics
Pfotenhauerstr. 108
01307 Dresden, Germany
www.mpi-cbg.de

• The Max Planck Society strives for gender equality and diversity. We welcome applications from all backgrounds, regardless of gender, nationality, ethnicity, sexual orientation, religion, age, and other components of identity.
• The Max Planck Society specifically aims to increase the proportion of women in the areas in which they are underrepresented. We therefore explicitly invite women to apply.
• The Max Planck Society is further committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
• The Max Planck Society supports the compatibility of family and career and is certified according to the "berufundfamilie" (“job and family”) audit.
• When you submit a job application to MPI-CBG, you are transmitting personal data. Please refer to our privacy notice for information on how we collect and process personal data in accordance with Art. 13 of the Datenschutz-Grundverordnung. By submitting your application you confirm that you have taken note of the information in our privacy notice.

• Lebenslauf
• Ausgefüllten Fragebogen (oben rechts "Fragebogen für ein Schulpraktikum")
• Letzten 2 Zeugnisse
• Sofern vorhanden: Zertifikate über zusätzliche Qualifikationen, Kurse, Praktika oder besondere schulische Leistungen.

Bitte habe Verständnis, dass wir nur vollständige Bewerbungen berücksichtigen können. Aus praktischen Gründen bevorzugen wir Bewerbungen aus dem näheren Umkreis. Es handelt sich bei dieser Ausschreibung um ein Praktikum ausschließlich für Schüler und Schülerinnen, die die Oberstufe oder gymnasiale Oberstufe aktiv besuchen.

(Achtung! Bist du interessiert an einem Studentenpraktikum, wende dich bitte an das IMPRS Programm https://www.mpi-cbg.de/de/karriere/opportunities-programs/doktorandenprogramm.

Attention! This announcement is an internship exclusively for students who are still attending school! If you are interested in a student internship, please use our IMPRS program (https://www.mpi-cbg.de/de/karriere/opportunities-programs/doktorandenprogramm).)

Unsere Bewerbungsplattform wird nur vom 01. August bis zum 31.August und vom 2. Januar bis 1. Februar eines jeden Jahres freigeschaltet. In dieser Zeit kannst Du dich bei uns online bewerben.

Bewirb dich unter folgenden Link: https://recruitingapp-2443.umantis.com/Vacancies/579/Application/CheckLogin/1?lang=ger.

Wir bemühen uns um eine Rückantwort innerhalb von 4 Wochen nach Ablauf der Einsendefrist.

Hast du noch Fragen, dann schreibe uns: Praktikumsanfrage@mpi-cbg.de. Bitte an diese Adresse KEINE Bewerbungsunterlagen schicken!

You are invited to visit http://www.csbdresden.de/join-us/as-a-postdoc/ for detailed information about the program and the application procedure.

Please send all inquiries regarding the ELBE Postdoctoral Fellows Program to the ELBE Program Office: elbeprogram[at]pks.mpg.de

You are invited to visit www.imprs-celldevosys.de for detailed information on the participating research groups, eligibility requirements and the application procedure.

Please send all inquiries regarding PhD positions to phd@mpi-cbg.de.