TECHNOLOGY DEVELOPMENT GROUPS

Biological membranes efficiently divide space into two compartments. Transport proteins in these membranes allow selective passage of solutes, thereby affecting the internal milieu and the physiology of cells. We want to obtain mechanistic insights into transporter function and use these to modulate activities of solute carriers in living cells to unravel the dynamic interplay of different transport proteins. To support these aims, we develop novel enabling technologies for protein research in parallel.

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The Sarov lab is developing tools that allow the systematic tracking of the protein components that build up the various cell structures. We are particularly interested in how the cell nucleus is restructured during development.

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