Research Groups

Selected Publications

Nicole Prior, Christopher J Hindley, Fabian Rost, Elena Melendez Esteban, Winnie W. Y. Lau, Berthold Gottgens, Steffen Rulands, Benjamin D Simons, Meritxell Huch
Lgr5+ bi-potential hepatoblasts reside at the apex of the embryonic liver progenitor pool. 
BioRxiv doi: doi.org/10.1101/485870
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Cordero-Espinoza L., Huch M
The balancing act of the liver: tissue regeneration vs fibrosis.
Journal of Clinical Investigation. (2018) Jan 2;128(1):85-96. doi: 10.1172/JCI93562. Epub 2018 Jan 2. PMID: 29293095
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Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, Gavarró LM, Bradshaw CR, Allen GE, Arnes-Benito R, Sidorova O, Gaspersz MP, Georgakopoulos N, Koo BK, Dietmann S, Davies SE, Praseedom RK, Lieshout R, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJ, Huch M
Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.
Nature Medicine (2017) Dec;23(12):1424-1435. doi: 10.1038/nm.4438. Epub 2017 Nov 13. 29131160
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Huch M, Knoblich JA, Lutolf MP, Martinez-Arias A
The hope and the hype of organoid research.
Development. (2017) Mar 15;144(6):938-941. PMID: 28292837
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Hindley CJ, Cordero-Espinoza L, Huch M
Organoids from adult liver and pancreas: stem cell biology and biomedical utility.
Developmental Biology (2016) Dec 15;420(2):251-261. Review.PMID:27364469
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Broutier L, Andersson-Rolf A, Hindley CJ, Boj SF, Clevers H, Koo BK, Huch M
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature Protocols (2016) Sep; 11(9): 1724-43. PMID: 27560176
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Huch, M. and Koo B.K.
Modeling mouse and human development using organoid cultures.
Development (2015) 142(18): 3113-3125. PMID: 26395140
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Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H.
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver.
Cell (2015) Jan 15;160(1-2):299-312. PMID: 25533785
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Huch M, Dorrell C, Boj SF, van Es JH, Li VSW, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries R, Grompe M, Clevers H.
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Nature (2013) Feb 14;494: 247-50. PMID: 23354049
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Barker N*, Huch M*, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H.
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.
Cell Stem Cell (2010) Jan 8;6(1):25-36. PMID: 20085740