Services & Facilities

* joined first author # joined corresponding author

2021

Giulio Formenti#, Arang Rhie, Jennifer Balacco, Bettina Haase, Jacquelyn Mountcastle, Olivier Fedrigo, Samara Brown, Marco Rosario Capodiferro, Farooq O Al-Ajli, Roberto Ambrosini, Peter Houde, Sergey Koren, Karen Oliver, Michelle Smith, Jason Skelton, Emma Betteridge, Jale Dolucan, Craig Corton, Iliana Bista, James Torrance, Alan Tracey, Jonathan Wood, Marcela Uliano-Silva, Kerstin Howe, Shane A McCarthy, Sylke Winkler, Woori Kwak, Jonas Korlach, Arkarachai Fungtammasan, Daniel Fordham, Vania Costa, Simon Mayes, Matteo Chiara, David S Horner, Eugene W Myers, Richard Durbin, Alessandro Achilli, Edward L Braun, Adam M Phillippy, Erich D Jarvis#, Erich D null
Complete vertebrate mitogenomes reveal widespread repeats and gene duplications.
Genome Biol, 22(1) Art. No. 120 (2021)
Open Access   DOI
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Lina Muhandes, Maria Chapsa, Martin Pippel, Rayk Behrendt, Yan Ge, Andreas Dahl, Buqing Yi, Alexander Dalpke, Sylke Winkler, Michael Hiller, Sebastien Boutin, Stefan Beissert, Rolf Jessberger, Padraic G Fallon, Axel Roers
Low threshold for cutaneous allergen sensitization but no spontaneous dermatitis or atopy in filaggrin-deficient mice.
J. Invest. Dermatol., Art. No. doi: 10.1016/j.jid.2021.02.763 (2021)
DOI
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Arang Rhie, Shane A McCarthy, Olivier Fedrigo, Joana Damas, Giulio Formenti, Sergey Koren, Marcela Uliano-Silva, William Chow, Arkarachai Fungtammasan, Juwan Kim, Chul Lee, Byung June Ko, Mark Chaisson, Gregory L Gedman, Lindsey J Cantin, Francoise Thibaud-Nissen, Leanne Haggerty, Iliana Bista, Michelle Smith, Bettina Haase, Jacquelyn Mountcastle, Sylke Winkler, Sadye Paez, Jonathon Howard, Sonja Vernes, Tanya M Lama, Frank Grutzner, Wesley C Warren, Christopher N Balakrishnan, Dave Burt, Julia M George, Matthew T Biegler, David Iorns, Andrew Digby, Daryl Eason, Bruce Robertson, Taylor Edwards, Mark Wilkinson, George Turner, Axel Meyer, Andreas F Kautt, Paolo Franchini, H William Detrich, Hannes Svardal, Maximilian Wagner, Gavin J P Naylor, Martin Pippel, Milan Malinsky, Mark Mooney, Maria Simbirsky, Brett T Hannigan, Trevor Pesout, Marlys Houck, Ann Misuraca, Sarah B Kingan, Richard J Hall, Zev Kronenberg, Ivan Sović, Christopher Dunn, Zemin Ning, Alex R Hastie, Joyce Lee, Siddarth Selvaraj, Richard E Green, Nicholas H Putnam, Ivo Gut, Jay Ghurye, Erik Garrison, Ying Sims, Joanna Collins, Sarah Pelan, James Torrance, Alan Tracey, Jonathan Wood, Robel E Dagnew, Dengfeng Guan, Sarah E London, David F Clayton, Claudio V Mello, Samantha R Friedrich, Peter V Lovell, Ekaterina Osipova, Farooq O Al-Ajli, Simona Secomandi, Heebal Kim, Constantina Theofanopoulou, Michael Hiller, Yang Zhou, Robert S Harris, Kateryna D Makova, Paul Medvedev, Jinna Hoffman, Patrick Masterson, Karen Clark, Fergal Martin, Kerstin Howe#, Paul Flicek, Brian Walenz, Woori Kwak, Hiram Clawson, Mark Diekhans, Luis Nassar, Benedict Paten, Robert H S Kraus, Andrew J Crawford, M Thomas P Gilbert, Guojie Zhang, Byrappa Venkatesh, Robert F Murphy, Klaus-Peter Koepfli, Beth Shapiro, Warren E Johnson, Federica Di Palma, Tomas Marques-Bonet, Emma Teeling, Tandy Warnow, Jennifer Marshall Graves, Oliver A Ryder, David Haussler, Stephen J O'Brien, Jonas Korlach, Harris A Lewin, Kerstin Howe#, Eugene W Myers#, Richard Durbin#, Adam M Phillippy#, Erich D Jarvis#
Towards complete and error-free genome assemblies of all vertebrate species.
Nature, 592(7856) 737-746 (2021)
Open Access   DOI
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Sarita Hebbar✳︎, Malte Lehmann✳︎, Sarah Behrens, Catrin Hälsig, Weihua Leng, Michaela Yuan, Sylke Winkler, Elisabeth Knust
Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila.
Biol Open, 10(1) Art. No. bio052332 (2021)
Open Access   DOI

2020

David Jebb✳︎, Zixia Huang✳︎, Martin Pippel✳︎, Graham M Hughes, Ksenia Lavrichenko, Paolo Devanna, Sylke Winkler, Lars S Jermiin, Emilia C Skirmuntt, Aris Katzourakis, Lucy Burkitt-Gray, David A Ray, Kevin F. Sullivan, Juliana G. Roscito, Bogdan Kirilenko, Liliana M Dávalos, Angelique P Corthals, Megan L Power, Gareth Jones, Roger D Ransome, Dina K N Dechmann, Andrea G Locatelli, Sébastien J Puechmaille, Olivier Fedrigo, Erich D Jarvis, Michael Hiller#, Sonja Vernes#, Eugene W Myers#, Emma Teeling#
Six reference-quality genomes reveal evolution of bat adaptations.
Nature, 583(7817) 578-584 (2020)
Open Access   DOI
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Irene Adrian-Kalchhauser, Anders Blomberg, Tomas Larsson, Zuzana Musilova, Claire R Peart, Martin Pippel, Monica Hongroe Solbakken, Jaanus Suurväli, Jean-Claude Walser, Joanna Yvonne Wilson, Magnus Alm Rosenblad, Demian Burguera, Silvia Gutnik, Nico Michiels, Mats Töpel, Kirill Pankov, Siegfried Schloissnig, Sylke Winkler
The round goby genome provides insights into mechanisms that may facilitate biological invasions.
BMC Biol, 18(1) Art. No. 11 (2020)
Open Access   DOI
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Martin Pippel✳︎, David Jebb✳︎, Franziska Patzold, Sylke Winkler, Heiko Vogel, Gene Myers, Michael Hiller#, Anna K Hundsdoerfer#
A highly contiguous genome assembly of the bat hawkmoth Hyles vespertilio (Lepidoptera: Sphingidae).
GigaScience, 9(1) Art. No. giaa001 (2020)
Open Access   DOI

2018

Juliana G. Roscito, Katrin Sameith, Martin Pippel, Kees-Jan Francoijs, Sylke Winkler, Andreas Dahl, Georg Papoutsoglou, Gene Myers, Michael Hiller
The genome of the tegu lizard Salvator merianae: combining Illumina, PacBio, and optical mapping data to generate a highly contiguous assembly.
GigaScience, 7(12) Art. No. giy141 (2018)
Open Access   PDF    DOI
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Samir Vaid, J Gray Camp, Lena Hersemann, Christina Eugster Oegema, Anne-Kristin Heninger, Sylke Winkler, Holger Brandl, Mihail Sarov, Barbara Treutlein, Wieland Huttner#, Takashi Namba#
A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex.
Development, 145(20) Art. No. dev169276 (2018)
DOI
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Virag Sharma, Thomas Lehmann, Heiko Stuckas, Liane Funke, Michael Hiller
Loss of RXFP2 and INSL3 genes in Afrotheria shows that testicular descent is the ancestral condition in placental mammals.
PLoS Biol, 16(6) Art. No. e2005293 (2018)
Open Access   PDF    DOI
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Marta Florio✳︎, Michael Heide✳︎, Anneline Pinson, Holger Brandl, Mareike Albert, Sylke Winkler, Pauline Wimberger, Wieland B. Huttner#, Michael Hiller#
Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex.
Elife, 7 Art. No. e32332 (2018)
Open Access   PDF    DOI
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Markus Grohme✳︎, Siegfried Schloissnig✳︎, Andrei Rozanski, Martin Pippel, George Robert Young, Sylke Winkler, Holger Brandl, Ian Henry, Andreas Dahl, Sean Powell, Michael Hiller, Eugene Myers, Jochen Rink
The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms.
Nature, 554(7690) 56-61 (2018)
Open Access   PDF    DOI
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Sergej Nowoshilow, Siegfried Schloissnig, Jifeng Fei, Andreas Dahl, Andy W C Pang, Martin Pippel, Sylke Winkler, Alex R Hastie, George Young, Juliana G. Roscito, Francisco Falcon, Dunja Knapp, Sean Powell, Alfredo Cruz, Han Cao, Bianca Habermann, Michael Hiller, Elly M. Tanaka, Eugene W Myers
The axolotl genome and the evolution of key tissue formation regulators.
Nature, 554(7690) 50-55 (2018)
Open Access   PDF    DOI

2017

V Albrecht, C Zweiniger, Vineeth Surendranath, Karl Lang, G Schöfl, Andreas Dahl, Sylke Winkler, V Lange, I Böhme, A H Schmidt
Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles.
HLA, 90(2) 79-87 (2017)
Open Access   DOI
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R Urrego, Sandra Milena Bernal-Ulloa, N A Chavarría, E Herrera-Puerta, Andrea Lucas-Hahn, D Herrmann, Sylke Winkler, Dorit Pache, H Niemann, N Rodriguez-Osorio
Satellite DNA methylation status and expression of selected genes in Bos indicus blastocysts produced in vivo and in vitro.
Zygote, 25(2) 131-140 (2017)
DOI
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Irene Adrian-Kalchhauser, Ola Svensson, Verena E Kutschera, Magnus Alm Rosenblad, Martin Pippel, Sylke Winkler, Siegfried Schloissnig, Anders Blomberg, Patricia Burkhardt-Holm
The mitochondrial genome sequences of the round goby and the sand goby reveal patterns of recent evolution in gobiid fish.
BMC Genomics, 18(1) Art. No. 177 (2017)
Open Access   PDF    DOI
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Stephanie Spannl✳︎, Alexandra Kumichel✳︎, Sarita Hebbar, Katja Kapp, Marcos Gonzalez-Gaitan, Sylke Winkler, Rosana Blawid, Gregor Jessberger, Elisabeth Knust
The Crumbs_C isoform of Drosophila shows tissue- and stage-specific expression and prevents light-dependent retinal degeneration.
Biol Open, 6(2) 165-175 (2017)
Open Access   PDF    DOI

2016

Nereo Kalebic, Elena Taverna, Stefania Tavano, Fong Kuan Wong, Dana Suchold, Sylke Winkler, Wieland B. Huttner, Mihail Sarov
CRISPR/Cas9-induced disruption of gene expression in mouse embryonic brain and single neural stem cells in vivo.
EMBO Rep, 17(3) 338-348 (2016)
Open Access   PDF    DOI
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Sandra Milena Bernal-Ulloa, Julia Heinzmann, Doris Herrmann, Klaus-Gerd Hadeler, Patrick Aldag, Sylke Winkler, Dorit Pache, Ulrich Baulain, Andrea Lucas-Hahn, Heiner Niemann
Cyclic AMP Affects Oocyte Maturation and Embryo Development in Prepubertal and Adult Cattle.
PLoS ONE, 11(2) Art. No. e0150264 (2016)
Open Access   PDF    DOI

2015

Sylke Winkler, K. Linke, Nicola Gscheidel, M. Meyer, D. Krabel
PCR-based detection of single sequence variants from a natural collection of the non-model tree species European Aspen Populus tremula (L.)
Silvae Genetica, 64(5-6) 259-269 (2015)
Open Access  

2013

Pooja Kumari, Patrick C Gilligan, Shimin Lim, Long Duc Tran, Sylke Winkler, Robin Philp, Karuna Sampath
An essential role for maternal control of Nodal signaling.
Elife, 2 Art. No. e00683 (2013)
Open Access   DOI

2011

Sylke Winkler, Nicola Gscheidel, Michael Brand
Mutant generation in vertebrate model organisms by TILLING.
Methods Mol Biol, 770 475-504 (2011)
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2010

Elena Quesada-Hernández, Luca Caneparo, Sylvia Schneider, Sylke Winkler, Michael Liebling, Scott E Fraser, Carl-Philipp Heisenberg
Stereotypical cell division orientation controls neural rod midline formation in zebrafish.
Curr Biol, 20(21) 1966-1972 (2010)
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2009

Radoslaw K Ejsmont, Mihail Sarov, Sylke Winkler, Kamil A Lipinski, Pavel Tomancák
A toolkit for high-throughput, cross-species gene engineering in Drosophila.
Nat Methods, 6(6) 435-437 (2009)
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2006

John W Hawes, Kevin L Knudtson, Helaman Escobar, George S Grills, Timothy C Hunter, Emily Jackson-Machelski, Heather Lin, David S Needleman, Rashmi Pershad, Glenis J. Wiebe
Evaluation of methods for sequence analysis of highly repetitive DNA templates.
J Biomol Tech, 17(2) 138-144 (2006)
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2005

Oliver Bartsch, Stefanie Schmidt, Marion Richter, Susanne Morlot, Eva Seemanová, Glenis J. Wiebe, Sasan Rasi
DNA sequencing of CREBBP demonstrates mutations in 56% of patients with Rubinstein-Taybi syndrome (RSTS) and in another patient with incomplete RSTS.
Hum Genet, 117(5) 485-493 (2005)
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Sylke Winkler, Anja Schwabedissen, Dana Backasch, Christian Bökel, Claudia Seidel, Stefanie Bönisch, Maximilian Fürthauer, Antje Kuhrs, Laura Cobreros, Michael Brand, Marcos González-Gaitán
Target-selected mutant screen by TILLING in Drosophila.
Genome Res, 15(5) 718-723 (2005)
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2004

Minna H Pöyhönen, Maarit M Peippo, Leena K Valanne, Kirsti E Kuokkanen, Susanna M Koskela, Oliver Bartsch, Sasan Rasi, Glenis J. Wiebe, Marketta Kähkönen, Helena A Kääriäinen
Hypertrichosis, hyperkeratosis, abnormal corpus callosum, mental retardation and dysmorphic features in three unrelated females.
Clin Dysmorphol, 13(2) 85-90 (2004)
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