- Simon Alberti
- Jan Brugués
- Suzanne Eaton
- Anne Grapin-Botton
- Stephan Grill
- Michael Hiller
- Alf Honigmann
- Meritxell Huch
- Wieland Huttner
- Anthony Hyman
- Florian Jug
- Elisabeth Knust
- Moritz Kreysing
- Teymuras Kurzchalia
- Carl Modes
- Gene Myers
- André Nadler
- Caren Norden
- Gaia Pigino
- Jochen Rink
- Ivo Sbalzarini
- Andrej Shevchenko
- Jacqueline Tabler
- Dora Tang
- Pavel Tomancak
- Agnes Toth-Petroczy
- Nadine Vastenhouw
- Christoph Zechner
- Marino Zerial
General Contact Information
Max Planck Institute
of Molecular Cell Biology and Genetics
- Grapin-Botton -
Current Lab Members
|Beydag-Tasöz, Belin Selcen||Predocfirstname.lastname@example.org||+49 351 210-2677|
|Dietze, Sophia||Apprentice Biologielaborantemail@example.com|
|Franz, Antje||Assistant to Anne Grapin-Bottonfirstname.lastname@example.org||+49 351 210-2730|
|Grapin-Botton, Anne||Directoremail@example.com||+49 351 210-2500|
|Katsumoto, Keiichi||Staff Scientistfirstname.lastname@example.org||+49 351 210-2672|
|Keshara, Rashmiparvathi||Predocemail@example.com||+49 351 210-2605|
|Kim, Yung Hae||Staff Scientistfirstname.lastname@example.org||+49 351 210-2671|
|Lee, Byung Ho||Postdocemail@example.com||+49 351 210-2983|
|Leuschner, Marit||Technicianfirstname.lastname@example.org||+49 351 210-2736|
|Petzold, Heike||Technicianemail@example.com||+49 351 210-2743|
|Schewin, Coline||Predocfirstname.lastname@example.org||+49 351 210-2676|
|Seijo Barandiaran, Irene||Postdocemail@example.com||+49 351 210-2984|
|Stratmann, Johannes||Postdocfirstname.lastname@example.org||+49 351 210-2981|
Although there is a considerable body of work on pancreatic endocrine cells due to their importance in regulation of blood glucose levels and consequently their link to wide-spread diseases such as diabetes mellitus, the development and fate choices these cells undergo in human have not been understood in detail yet. My project focuses on characterizing human pancreatic endocrine progenitors better, and trying to understand how they choose their subsequent endocrine fates. I mainly use in vitro pancreatic differentiation systems to characterize these cells via live imaging, analyzing their endocrine subtype commitment, transcriptional profile and thus the heterogeneity within the population.
I am investigating how the planar polarity pathway can organize pancreatic progenitors in the complex network of tubes composing the pancreas. A better understanding of pancreatic epithelium architecture and how it influences cell fate choices will provide new insights into disorders associated with cyst formation and diabetes.
I study β-cell proliferation and β-cell maturation mechanisms. Diabetes is caused by many factors, but basically, diabetes patients have a problem in producing Insulin to control blood glucose level, which can involve decreased β-cell number and impaired β-cell function. If we can control β-cell proliferation and β-cell maturation in their body, we hope to overcome diabetes. I more specifically study Wnt signaling in these steps.
Yung Hae Kim
I'm working on differentiation dynamics of pancreatic progenitors to endocrine lineage during pancreas development by observing pancreatic progenitors' behaviors at single-cell resolution from mouse embryonic pancreas and human pluripotent stem cell (hPSC)-derived pancreatic cells. I use 2-D and 3-D live imaging, lineage tracing, single-cell transcription analysis, hPSC differentiation, and hPSC-derived pancreatic organoids. I'm also collaborating with mathematicians/physicists to model our data and test the model experimentally. The ultimate goal is to be able to control progenitor expansion and/or endocrine differentiation to boost production of beta-cells in vitro as a mean of beta-cell replacement therapy for type 1 diabetes.
Byung Ho Lee
Byung Ho is studying the influence of biophysical stimuli on the growing pancreas and pancreatic organoids. He is particularly interested in how mechanical deformations influence branching and differentiation of the pancreas and pancreatic organoids.
In addition to tasks related to laboratory organization, I work on the topic of apico- basal cell polarity in 3D pancreas organoid cultures.
I work with human pluripotent stem cells, differentiate them into pancreatic cells and make pancreatic organoids. I characterize cells by flow cytometry, qPCR and immunofluorescent staining. I also take care of lab organization.
It was recently shown in our lab that during development, the early secretion of fluid in the pancreas likely shapes the structure of the ductal network that deliver enzymes digesting food from their production site, in acini, to the intestine (Dahl-Jensen et al., 2018). In my project I study the influence of exocrine secretion flow on the morphogenesis of this ductal network. I am particularly interested in how the flow is generated, how it is sensed and its influence on the remodeling of the ducts.
I am studying planar cell polarity during pancreas development. I am particularly interested in understanding how tissue asymmetry is established and to analyze its role on cell differentiation.
Both, pancreas and nervous system contain highly specified cell types with shared secretory activities but distinct physiological functions i.e. metabolism vs. signal transduction. Intriguingly, many genes are shared across the two tissues. During my project, I intend to molecularly decode the conservation of gene regulatory networks (GRNs) of transcription factors, crucial for pancreas and spinal cord development. In addition, I aim to dissect the conservation of gene regulatory regions for key genes, controlling spatio-temporal gene expression. This will provide a regulatory map to help understand disease-causing mutations in non-coding regions controlling appropriate cell biogenesis in development.