Research Groups

The shape and function of tissues, organs and organisms are profoundly linked and emerge during the process of morphogenesis. Traditionally, the underlying principles of morphogenesis have been investigated by studying the embryogenesis of optically and genetically accessible model species. However, due to the intrinsic complexity of the evolutionarily evolved molecular, cellular, and tissue feedbacks, inferring the rules of morphogenesis from watching and manipulating embryogenesis is a formidable challenge.

In this project, we aim to develop an in vitro tissue reconstitution platform that allows for the rigorous testing of the current paradigms of tissue shape generation and in principle will allow to generate arbitrary 3D tissue shapes. The key idea is to selectively program stress patterns into flat, surface-bonded, epithelial monolayers by micro-patterning curvature inducing cell-types. Patterned monolayers can then be released from the surface and observed folding into their pre-programmed 3D shapes by high resolution microscopy.

The successful candidate will join an interdisciplinary cutting-edge research project funded by the VW-foundation. The project integrates cell and tissue biology (this position, Honigmann lab), surface chemistry (PhD position, Nadler lab CBG) and theoretical physics (PhD position, Modes lab CSBD).

Candidates with a background in cell and tissue biology, tissue mechanics and micro-patterning are preferred. If you are excited about this project and consider yourself a team player who likes to work interdisciplinary, submit your application to honigman@mpi-cbg.de.