Anthony Hyman

Anthony Hyman, MPI-CBG Dresden We are interested in using high throughput genetics, using both localisation and phenotypic studies, to look at the function of organelles in mitosis. For phenotypic studies, we have used RNA interference in C.elegans embryos. We have identified about 700 genes required for cell division. For localisation, we have developed techniques involving bacterial artificial chromosomes, which allow localisation of proteins under their own promotor and regulatory sequences. By clustering the data from these different forms of data, we can combine these reciprocal data sets to define genes required for different mitotic processes with high confidence.