Marino Zerial

Principles of cell and tissue organization: from endocytosis to a systems understanding of liver structure and function

Our vision is to develop a systems understanding of the molecular mechanisms underlying cell and tissue organization. Over the years, we have been studying the molecular mechanisms of endocytosis, unravelling the key role played by Rab GTPases and their effectors. This work has led us to demonstrate that Rab5 is a master regulator of early endosome biogenesis. We have recently conducted a systems biology analysis by genome-wide RNAi screening in HeLa cells and in C. elegans, using quantitative multi-parametric image analysis (QMPIA). This led us to gain insights into the design principles of the endosomal system. We are now ready to apply this methodology to the multi-scale analysis of tissue organization and function.

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