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Joe Howard

Publications

2009
Marzuk M Kamal, Deryck Mills, Michal Grzybek, Jonathon Howard
Measurement of the membrane curvature preference of phospholipids reveals only weak coupling between lipid shape and leaflet curvature.
Proc. Natl. Acad. Sci. U.S.A., Vol. 106, no. 52, pp. 22245-22250, 2009
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Marija Zanic, Jeffrey H Stear, Anthony A Hyman, Jonathon Howard
EB1 recognizes the nucleotide state of tubulin in the microtubule lattice
PLoS ONE, Vol. 4, no. 10, pp. e7585-1-e7585-5, 2009
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Vladimir Varga, Cecile Leduc, Volker Bormuth, Stefan Diez, Jonathon Howard
Kinesin-8 motors act cooperatively to mediate length-dependent microtubule depolymerization
Cell, Vol. 138, no. 6, pp. 1174-1183, 2009
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Volker Bormuth, Vladimir Varga, Jonathon Howard, Erik Schaffer
Protein friction limits diffusive and directed movements of kinesin motors on microtubules
Science, Vol. 325, no. 5942, pp. 870-873, 2009
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Marzuk Mahmud Kamal
Coupling between membrane curvature and lipid geometry (Phd-thesis)
2009
Volker Bormuth
Optimized optical tweezers to study the mechanics of kinesin-8: stepping, slipping, protein friction (Phd-thesis)
2009
Jonathon Howard, Anthony A Hyman
Growth, fluctuation and switching at microtubule plus ends
Nat. Rev. Mol. Cell Biol., Vol. 10, no. 8, pp. 569-574, 2009
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Jonathon Howard
Mechanical signaling in networks of motor and cytoskeletal proteins
Annu Rev Biophys, Vol. 38, pp. 217-234, 2009
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2008
Henrik Bringmann
Mechanical and genetic separation of aster- and midzone-positioned cytokinesis
Biochem. Soc. Trans., Vol. 36, no. Pt 3, pp. 381-383, 2008
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Alvaro H Crevenna, Sineej Madathil, Daniel N Cohen, Michael Wagenbach, Karim Fahmy, Jonathon Howard
Secondary structure and compliance of a predicted flexible domain in kinesin-1 necessary for cooperation of motors
Biophys. J., Vol. 95, no. 11, pp. 5216-5227, 2008
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Yu-Chen Lee, Gregory Block, Huiwen Chen, Emma Folch-Puy, Robert Foronjy, Roxana Jalili, Christian Bille Jendresen, Masashi Kimura, Edward Kraft, Soren Lindemose, Jin Lu, Teri McLain, Leta Nutt, Santiago Ramon-Garcia, Joseph Smith, Aaron Spivak, Michael L Wang, Marija Zanic, Sue-Hwa Lin
One-step isolation of plasma membrane proteins using magnetic beads with immobilized concanavalin A
Protein Expr. Purif., Vol. 62, no. 2, pp. 223-229, 2008
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Khaled Khairy, JiJin Foo, Jonathon Howard
Shapes of red blood cells : comparison of 3D confocal images with the bilayer-couple model
Cell Mol Bioeng, Vol. 1, no. 2-3, pp. 173-181, 2008
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Jonathon Howard
Molecular mechanics of cells and tissues
Cell Mol Bioeng, Vol. 1, no. 1, pp. 24-32, 2008
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Susanne Bechstedt, Jonathon Howard
Hearing mechanics: a fly in your ear
Curr. Biol., Vol. 18, no. 18, pp. R869-870, 2008
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Volker Bormuth, Anita Jannasch, Marcel Ander, Carlos M van Kats, Alfons van Blaaderen, Jonathon Howard, Erik Schaffer
Optical trapping of coated microspheres.
Opt. Express, Vol. 16, no. 18, pp. 13831-13844, 2008
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Khaled Khairy, Jonathon Howard
Spherical harmonics-based parametric deconvolution of 3D surface images using bending energy minimization
Med. Image Anal., Vol. 12, no. 2, pp. 217-227, 2008
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Gary J Brouhard, Jeffrey H Stear, Tim L Noetzel, Jawdat Al-Bassam, Kazuhisa Kinoshita, Stephen C Harrison, Jonathon Howard, Anthony A Hyman
XMAP215 Is a Processive Microtubule Polymerase
Cell, Vol. 132, no. 1, pp. 79-88, 2008
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2007
Ingmar H. Riedel-Kruse, Andreas Hilfinger, Jonathon Howard, Frank Jülicher
How molecular motors shape the flagellar beat
HFSP J., Vol. 1, no. 1, pp. 192-208, 2007
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Khaled Khairy, Jacques Pecreaux, Jonathon Howard
Spherical Harmonics 3D Active Contours for Membrane Bilayer-Bound Surfaces
Peer-reviewed conference paper at MICCAI society meeting 2007, MICCAI, Copenhagen, no. 0, Chapt. 1/7, pp. 43-54, 2007
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Ingmar Riedel
Mechanics of the axoneme: self-organized beating patterns and vortex arrays of spermatozoa (Phd-thesis)
2007
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A. Doraiswamy, C. Dinu, R. Cristescu, P. B. Messersmith, B. J. Chisholm, S. J. Stafslien, D. B. Chrisey, R. J. Narayan
Matrix-assisted pulsed-laser evaporation of DOPA-modified poly(ethylene glycol) thin films
J Adhes Sci Technol, Vol. 21, no. 3-4, pp. 287-299, 2007
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C.Z. Dinu, V.C. Dinca, S. Soare, A. Moldovan, D. Smarandache, N. Scarisoareanu, A. Barbalat, R. Birjega, M. Dinescu, V. Ferrari DiStefano
Monitorizing nitinol alloy surface reactions for biofouling studies
Appl Surf Sci, Vol. 253, no. 19, pp. 7719-7723, 2007
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D. Selmeczi, S.F. Tolic-Norrelykke, E. Schaeffer, P.H. Hagedorn, S. Mosler, K. Berg-Sorensen, N.B. Larsen, H. Flyvbjerg
Brownian Motion after Einstein and Smoluchowski: Some New Applications and New Experiments
Acta Soc. Zool. Bohem., Vol. 38, no. 8, pp. 2407-2431, 2007
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Cerasela Zoica Dinu, D.B. Chrisey, Stefan Diez, Jonathon Howard
Cellular Motors for Molecular Manufactoring
Anat. Rec., Vol. 290, no. 10, pp. 1203-1212, 2007
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Cerasela Zoica Dinu, V. Dinca, Jonathon Howard, D. B. Chrisey
Printing technologies for fabrication of bioactive and regular microarrays of streptavidin
Appl Surf Sci, Vol. 253, no. 19, pp. 8119-8124, 2007
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Erik Schaffer, Simon F. Norrelykke, Jonathon Howard
Surface forces and drag coefficients of microspheres near a plane surface measured with optical tweezers
Langmuir, Vol. 23, no. 7, pp. 3654-3665, 2007
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Celine Elie-Caille, Fedor Severin, Jonne Helenius, Jonathon Howard, Daniel J. Muller, Anthony A. Hyman
Straight GDP-tubulin protofilaments form in the presence of taxol
Curr. Biol., Vol. 17, no. 20, pp. 1765-1770, 2007
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Susanne Bechstedt, Jonathon Howard
Models of hair cell mechanotransduction
Current Topics in Membranes, Elsevier, Amsterdam, Chapt. 14, pp. 399-424, 2007
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Jonathon Howard, Iva M. Tolic-Nørrelykke
Bundling, sliding, and pulling microtubules in cells and in silico
HFSP J., Vol. 1, no. 1, pp. 11-14, 2007
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Cecile Leduc, Felix Ruhnow, Jonathon Howard, Stefan Diez
Detection of fractional steps in cargo movement by the collective operation of kinesin-1 motors
Proc. Natl. Acad. Sci. U.S.A., Vol. 104, no. 26, pp. 10847-10852, 2007
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Volker Bormuth, Jonathon Howard, Erik Schaffer
LED illumination for video-enhanced DIC imaging of single microtubules
J. Microsc., Vol. 226, no. 1, pp. 1-5, 2007
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Jonathon Howard, Anthony A Hyman
Microtubule polymerases and depolymerases
Curr. Opin. Cell Biol., Vol. 19, no. 1, pp. 31-35, 2007
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2006
Jacques Pecreaux, Christophe Zimmer, Jean-Christophe Olivio-Marin
Biophysical active contours for cell tracking I: Tension and bending
International conference on image processing (ICIP), IEEE Operations Center, Piscataway, no. 0, pp. 1949-1952, 2006
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Khaled Khairy, David Budil, Piotr Fajer
Nonlinear-least-squares analysis of slow motional regime EPR spectra
J Magn Reson, Vol. 183, no. 1, pp. 152-159, 2006
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Alvaro Hernan Crevenna-Escobar
kinesin-1 mechanical flexibility and motor cooperation (Phd-thesis)
2006
Jacques Pecreaux, Jens-Christian Roper, Karsten Kruse, Frank Julicher, Anthony A Hyman, Stephan W Grill, Jonathon Howard
Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators
Curr. Biol., Vol. 16, no. 21, pp. 2111-2122, 2006
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Vladimir Varga, Jonne Helenius, Kozo Tanaka, Anthony A. Hyman, Tomoyuki U. Tanaka, Jonathon Howard
Yeast kinesin-8 depolymerizes microtubules in a lenght-dependent manner
Nat. Cell. Biol., Vol. 8, no. 9, pp. 957-962, 2006
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Simon F. Tolic-Norrelykke, Erik Schäffer, Jonathon Howard, Francesco S. Pavone, Frank Jülicher, Henrik Flyvbjerg
Calibration of optical tweezers with positional detection in the back focal plane
Rev Sci Instrum, Vol. 77, no. 10, pp. 103101(1)-103101(11), 2006
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Jonathon Howard
Protein power strokes
Curr. Biol., Vol. 16, no. 14, pp. 517-519, 2006
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Jonathon Howard
Elastic and damping forces generated by confined arrays of dynamic microtubules
Phys Biol, Vol. 3, no. 1, pp. 54-66, 2006
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Jacob Kerssemakers, Jonathon Howard, Henry Hess, Stefan Diez
The distance that kinesin-1 holds its cargo from the microtubule surface measured by fluorescence interference contrast microscopy
Proc. Natl. Acad. Sci. U.S.A., Vol. 103, no. 43, pp. 15812-15817, 2006
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Cerasela Zoica Dinu, Joerg Opitz, Wolfgang Pompe, Jonathon Howard, Michael Mertig, Stefan Diez
Parallel Manipulation of Bifunctional DNA Molecules on Structured Surfaces Using Kinesin-Driven Microtubules
Small, Vol. 2, no. 8-9, pp. 1090-1098, 2006
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Jonne Helenius, Gary Brouhard, Yannis Kalaidzidis, Stefan Diez, Jonathon Howard
The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends
Nature, Vol. 441, no. 7089, pp. 115-119, 2006
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2005
Bartosz Balana
Influence of culture conditions on differentiation and bioelectrical properties of human mesenchymal stem cells (Phd-thesis)
2005
Joe Howard
Q & A
Curr. Biol., Vol. 15, no. 18, pp. R743-R744, 2005
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Anthony A. Hyman, Jonathon Howard
Cell structure and dynamics
Curr. Opin. Cell Biol., Vol. 17, pp. 1-2, 2005
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Ingmar H Riedel, Karsten Kruse, Jonathon Howard
A self-organized vortex array of hydrodynamically entrained sperm cells.
Science, Vol. 309, no. 5732, pp. 300-303, 2005
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Kate Poole, Khaled Khairy, Jens Friedrichs, Clemens Franz, David A Cisneros, Jonathon Howard, Daniel Mueller
Molecular-scale topographic cues induce the orientation and directional movement of fibroblasts on two-dimensional collagen surfaces.
J. Mol. Biol., Vol. 349, no. 2, pp. 380-386, 2005
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2004
Andreas Deutsch, Jonathon Howard, Martin Falcke, Walter Zimmermann
Function and regulation of cellular systems
Birkhäuser, Basel, pp. 1-449, 2004
Ji-Jinn Foo, Vincent Chan, and Kuo-Kang Liu
Shape Recovery of an Optically Trapped Vesicle: Effect of Flow Velocity and Temperature
IEEE Trans Nanobioscience., Vol. 3, no. 2, pp. 96-100, 2004
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Fengzhi Jiang, Khaled Khairy, Kate Poole, Jonathon Howard, Daniel J Muller
Creating nanoscopic collagen matrices using atomic force microscopy
Microsc Res Tech, Vol. 64, no. 5-6, pp. 435-440, 2004
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Fengzhi Jiang, Heinrich Horber, Jonathon Howard, Daniel J Muller
Assembly of collagen into microribbons: effects of pH and electrolytes
J Struct Biol., Vol. 148, no. 3, pp. 268-278, 2004
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S. Walheim, E. Schäffer, U. Steiner
Self-organized organic nanostructures: structure formation in thin polymer blend films
Surf interface anal, Vol. 36, no. 2, pp. 195-196, 2004
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Ravi K Sawhney, Jonathon Howard
Molecular dissection of the fibroblast-traction machinery.
Cell Motil Cytoskeleton, Vol. 58, no. 3, pp. 175-185, 2004
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Ryoma Ohi, Tanuj Sapra, Jonathan Howard, Timothy J Mitchison
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation.
Mol. Biol. Cell, Vol. 15, no. 6, pp. 2895-2906, 2004
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Carolyn J Lawrence, R Kelly Dawe, Karen R Christie, Don W Cleveland, Scott C Dawson, Sharyn A Endow, Lawrence S B Goldstein, Holly V Goodson, Nobutaka Hirokawa, Jonathon Howard, Russell L Malmberg, J Richard McIntosh, Harukata Miki, Timothy J Mitchison, Yasushi Okada, Anireddy S N Reddy, William M Saxton, Manfred Schliwa, Jonathan M Scholey, Ronald D Vale, Claire E Walczak, Linda Wordeman
A standardized kinesin nomenclature.
J. Cell Biol., Vol. 167, no. 1, pp. 19-22, 2004
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Henry Haeberle, Mika Fujiwara, Jody Chuang, Michael M Medina, Mayuri V Panditrao, Susanne Bechstedt, Jonathon Howard, Ellen A Lumpkin
Molecular profiling reveals synaptic release machinery in Merkel cells.
Proc. Natl. Acad. Sci. U.S.A., Vol. 101, no. 40, pp. 14503-14508, 2004
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Mihai D Morariu, Erik Schäffer, Ullrich Steiner
Molecular Forces Caused by the Confinement of Thermal Noise
Phys Rev Lett., Vol. 92, no. 15, pp. 1-4, 2004
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Erik Schäffer, Uwe Thiele
Dynamic domain formation in membranes: Thickness-modulation induced phase separation
Eur Phys J E., Vol. 14, pp. 169-175, 2004
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Stefan Diez, Jonne H. Helenius, Joe Howard
Biomolecular Motors Operating in Engineered Environments
Nanobiotechnology, Wiley, Weinheim, Chapt. 13, pp. 185-199, 2004
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Jonathon Howard, Susanne Bechstedt
Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors.
Curr. Biol., Vol. 14, no. 6, pp. 224-226, 2004
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William R Schief, Rutilio H Clark, Alvaro H Crevenna, Jonathon Howard
Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism.
Proc. Natl. Acad. Sci. U.S.A., Vol. 101, no. 5, pp. 1183-1188, 2004
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2003
Erik Schäffer, Stephan Harkema, Monique Roerdink, Ralf Blossey, Ullrich Steiner
Thermomechanical Lithography: Pattern Replication Using a Temperature Gradient Driven Instability
Adv Mater., Vol. 15, no. 6, pp. 514-517, 2003
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Mihai D Morariu, Nicoleta E Voicu, Erik Schaffer, Zhiqun Lin, Thomas P Russell, Ullrich Steiner
Hierarchical structure formation and pattern replication induced by an electric field.
Nat Mater., Vol. 2, no. 1, pp. 48-52, 2003
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Stephan Harkema, Erik Schäffer, Mihai D. Morariu, Ullrich Steiner
Pattern Replication by Confined Dewetting
Langmuir, Vol. 19, pp. 9714-9718, 2003
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Erik Schäffer, Stephan Harkema, Monique Roerdink, Ralf Blossey, Ullrich Steiner
Morphological Instability of a Confined Polymer Film in a Thermal Gradient
Macromolecules, Vol. 36, pp. 1645-1655, 2003
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M D Morariu, E. Schäffer, U. Steiner
Capillary instabilities by fluctuation induced forces
Eur Phys J E., Vol. 12, pp. 375-381, 2003
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Stefan Diez, Cordula Reuther, Cerasela Dinu, Ralf Seidel, Michael Mertig, Wolfgang Pompe, Jonathon Howard
Stretching and Transporting DNA Molecules Using Motor Proteins
Nano Lett., Vol. 3, no. 9, pp. 1251-1254, 2003
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Stephan W Grill, Jonathon Howard, Erik Schaffer, Ernst H K Stelzer, Anthony A Hyman
The distribution of active force generators controls mitotic spindle position.
Science, Vol. 301, no. 5632, pp. 518-521, 2003
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Joe Howard
A molecular view of the cell
Nature, Vol. 421, no. 1, pp. 115-115, 2003
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Andrew W Hunter, Michael Caplow, David L Coy, William O Hancock, Stefan Diez, Linda Wordeman, Jonathon Howard
The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule ends
Mol Cell., Vol. 11, no. 2, pp. 445-457, 2003
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Joe Howard, Anthony A Hyman
Dynamics and mechanics of the microtubule plus end.
Nature, Vol. 422, no. 6933, pp. 753-758, 2003
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John Clemmens, Henry Hess, Jonathon Howard, Viola Vogel
Analysis of Microtubule Guidance in Open Microfabricated Channels Coated with the Motor Protein Kinesin
Langmuir, Vol. 19, no. 5, pp. 1738-1744, 2003
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2002
Jonathon Howard
Mechanical-to-Chemical Transduction by Motor Proteins
Biophysics of the Cochlea: from Molecules to Models, World Scientific, New Jersey, pp. 37-46, 2002
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William O. Hancock, Jonathon Howard
Kinesins: Processivity and Chemomechanical Coupling
Molecular Motors, Wiley, Hoboken, NJ, USA, Chapt. 2/3, 2002
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Jonathon Howard
Mechanics of Motor Proteins
Physics of bio-molecules and cells. Les Houches Session LXXV, Springer-Verlag Telos, Berlin, pp. 69-69ff, 2002
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Erik Schaffer, S. Harkema, R. Blossey, U. Steiner
Temperature-gradient induced instability in polymer films
Europhys Lett., Vol. 60, no. 2, pp. 255-261, 2002
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Dani B. N. Vinh, Joshua W. Kern, William O. Hancock, Jonathon Howard, Trisha N. Davis
Reconstitution and characterization of budding yeast gamma-tubulin complex.
Mol. Biol. Cell, Vol. 13, no. 4, pp. 1144-1157, 2002
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Ravi K. Sawhney, Jonathon Howard
Slow local movements of collagen fibers by fibroblasts drive the rapid global self-organization of collagen gels.
J. Cell Biol., Vol. 157, no. 6, pp. 1083-1091, 2002
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Stefan Diez, William R. Schief, Jonathon Howard
Molecular motors: single-molecule recordings made easy
Curr. Biol., Vol. 12, no. 6, pp. 203-205, 2002
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Henry Hess, John Clemmens, Jonathon Howard, Viola Vogel
Surface Imaging by Self-Propelled Nanoscale Probes
Nano Lett., Vol. 2, no. 2, pp. 113-116, 2002
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Henry Hess, Jonathon Howard, Viola Vogel
A Piconewton Forcemeter Assembled from Microtubules and Kinesins
Nano Lett., Vol. 2, no. 10, pp. 1113-1115, 2002
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2001
Henry Hess, John Clemmens, Dong Qin, Jonathon Howard, Viola Vogel
Light-Controlled Molecular Shuttles Made from Motor Proteins Carrying Cargo on Engineered Surfaces
Nano Lett., Vol. 1, no. 5, pp. 235-239, 2001
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Jonathon Howard
Mechanics of Motor Proteins and the Cytoskeleton
Sinauer Associates, Sunderland, Massachusetts, 2001
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W R Schief, J Howard
Conformational changes during kinesin motility.
Curr. Opin. Cell Biol., Vol. 13, no. 1, pp. 19-28, 2001
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1999
W O Hancock, J Howard
Kinesin's processivity results from mechanical and chemical coordination between the ATP hydrolysis cycles of the two motor domains.
Proc. Natl. Acad. Sci. U.S.A., Vol. 96, no. 23, pp. 13147-13152, 1999
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John R Dennis, Jonathon Howard, Viola Vogel
Molecular shuttles: directed motion of microtubules along nanoscale kinesin tracks
Nanotechnology, Vol. 10, pp. 232-236, 1999
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D L Coy, W O Hancock, M Wagenbach, J Howard
Kinesin's tail domain is an inhibitory regulator of the motor domain.
Nat. Cell. Biol., Vol. 1, no. 5, pp. 288-292, 1999
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D L Coy, M Wagenbach, J Howard
Kinesin takes one 8-nm step for each ATP that it hydrolyzes.
J. Biol. Chem., Vol. 274, no. 6, pp. 3667-3671, 1999
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1998
W O Hancock, J Howard
Processivity of the motor protein kinesin requires two heads.
J. Cell Biol., Vol. 140, no. 6, pp. 1395-1405, 1998
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1997
J Howard
Molecular motors: structural adaptations to cellular functions.
Nature, Vol. 389, no. 6651, pp. 561-567, 1997
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1996
J Howard, J A Spudich
Is the lever arm of myosin a molecular elastic element?
Proc. Natl. Acad. Sci. U.S.A., Vol. 93, no. 9, pp. 4462-4464, 1996
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1995
E Meyhofer, J Howard
The force generated by a single kinesin molecule against an elastic load
Proc. Natl. Acad. Sci. U.S.A., Vol. 92, no. 2, pp. 574-578, 1995
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