| 2011 |
| Krastev, Dragomir; Slabicki, Mikolaj; Paszkowski-Rogacz, Maciej; Hubner, Nina C; Junqueira, Magno; Shevchenko, Andrej; Mann, Matthias; Neugebauer, Karla M.; Buchholz, Frank |
| A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. |
| Nat. Cell Biol., 13, no. 7, pp. 809-818, (2011) |
| Nitzsche, Anja |
| Role of cohesin in the maintenance of embryonic stem cell identitiy |
| [Doctoral Thesis] Technische Universität Dresden, (2011) |
| 2010 |
| Paszkowski-Rogacz, Maciej |
| Integration and analysis of phenotypic data from functional screens |
| [Doctoral Thesis] Technische Universität Dresden, (2010) |
| Surendranath, Vineeth; Chusainow, Janet; Hauber, Joachim; Buchholz, Frank; Habermann, Bianca |
| SeLOX--a locus of recombination site search tool for the detection and directed evolution of site-specific recombination systems. |
| Nucleic Acids Res., 38, no. Suppl. 2, pp. 293-298, (2010) |
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| Slabicki, Mikolaj; Theis, Mirko; Krastev, Dragomir; Samsonov, Sergey; Mundwiller, Emeline; Junqueira, Magno; Paszkowski-Rogacz, Maciej; Teyra, Joan; Heninger, Anne-Kristin; Poser, Ina; Prieur, Fabienne; Truchetto, Jérémy; Confavreux, Christian; Marelli, Cécilia; Durr, Alexandra; Camdessanche, Jean Philippe; Brice, Alexis; Shevchenko, Andrej; Pisabarro, Maria Teresa; Stevanin, Giovanni; Buchholz, Frank |
| A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. |
| PLoS Biol., 8, no. 6, pp. 1000408-1000408, (2010) |
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| Yang, Yuansheng; Mariati, -; Chusainow, Janet; Yap, Miranda G S |
| DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines. |
| J. Biotechnol., 147, no. 3-4, pp. 180-185, (2010) |
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| Paszkowski-Rogacz, Maciej; Slabicki, Mikolaj; Pisabarro, Maria Teresa; Buchholz, Frank |
| PhenoFam-gene set enrichment analysis through protein structural information. |
| BMC Bioinformatics, 11, pp. 254-254, (2010) |
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| Hutchins, James R A; Toyoda, Yusuke; Hegemann, Björn; Poser, Ina; Hériché, Jean-Karim; Sykora, Martina M; Augsburg, Martina; Hudecz, Otto; Buschhorn, Bettina A; Bulkescher, Jutta; Conrad, Christian; Comartin, David; Schleiffer, Alexander; Sarov, Mihail; Pozniakovsky, Andrei I.; Slabicki, Mikolaj; Schloissnig, Siegfried; Steinmacher, Ines; Leuschner, Marit; Ssykor, Andrea; Lawo, Steffen; Pelletier, Laurence; Stark, Holger; Nasmyth, Kim; Ellenberg, Jan; Durbin, Richard; Buchholz, Frank; Mechtler, Karl; Hyman, Anthony A.; Peters, Jan-Michael |
| Systematic analysis of human protein complexes identifies chromosome segregation proteins. |
| Science, 328, no. 5978, pp. 593-599, (2010) |
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| Butter, Falk; Kappei, Dennis; Buchholz, Frank; Vermeulen, Michiel; Mann, Matthias |
| A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth. |
| EMBO Rep., 11, no. 4, pp. 305-311, (2010) |
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| Collinet, Claudio; Stöter, Martin; Bradshaw, Charles R.; Samusik, Nikolay; Rink, Jochen; Kenski, Denise; Habermann, Bianca; Buchholz, Frank; Henschel, Robert; Mueller, Matthias S; Nagel, Wolfgang E; Fava, Eugenio; Kalaidzidis, Yannis; Zerial, Marino |
| Systems survey of endocytosis by multiparametric image analysis. |
| Nature, 464, no. 7286, pp. 243-249, (2010) |
| Download PDFDownload Supplementary Text FileDownload Supplementary Image File |
| 2009 |
| Buchholz, Frank |
| Engineering DNA processing enzymes for the postgenomic era. |
| Curr. Opin. Biotechnol., 20, no. 4, pp. 383-389, (2009) |
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| Buchert, Michael; Darido, Charbel; Lagerqvist, Ebba; Sedello, Anna; Cazevieille, Chantal; Buchholz, Frank; Bourgaux, Jean-Francois; Pannequin, Julie; Joubert, Dominique; Hollande, Frédéric |
| The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1. |
| Gastroenterology, 137, no. 1, pp. 156-164, (2009) |
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| Lawo, Steffen; Bashkurov, Mikhail; Mullin, Michael; Ferreria, Mariana Gomez; Kittler, Ralf; Habermann, Bianca; Tagliaferro, Andrea; Poser, Ina; Hutchins, James R A; Hegemann, Björn; Pinchev, Deborah; Buchholz, Frank; Peters, Jan-Michael; Hyman, Anthony A.; Gingras, Anne-Claude; Pelletier, Laurence |
| HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. |
| Curr. Biol., 19, no. 10, pp. 816-826, (2009) |
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| Theis, Mirko; Slabicki, Mikolaj; Junqueira, Magno; Paszkowski-Rogacz, Maciej; Sontheimer, Jana; Kittler, Ralf; Heninger, Anne-Kristin; Glatter, Timo; Kruusmaa, Kristi; Poser, Ina; Hyman, Anthony A.; Pisabarro, Maria Teresa; Gstaiger, Matthias; Aebersold, Rudolf; Shevchenko, Andrej; Buchholz, Frank |
| Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division. |
| EMBO J., 28, no. 10, pp. 1453-1465, (2009) |
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| Ding, Li; Paszkowski-Rogacz, Maciej; Nitzsche, Anja; Slabicki, Mikolaj; Heninger, Anne-Kristin; Vries, Ingrid de; Kittler, Ralf; Junqueira, Magno; Shevchenko, Andrej; Schulz, Herbert; Hubner, Norbert; Doss, Michael Xavier; Sachinidis, Agapios; Hescheler, Juergen; Iacone, Roberto; Anastassiadis, Konstantinos; Stewart, A. Francis; Pisabarro, Maria Teresa; Caldarelli, Antonio; Poser, Ina; Theis, Mirko; Buchholz, Frank |
| A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. |
| Cell Stem Cell, 4, no. 5, pp. 403-415, (2009) |
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| Trouillas, Marina; Saucourt, Claire; Guillotin, Bertrand; Gauthereau, Xavier; Ding, Li; Buchholz, Frank; Doss, Michael Xavier; Sachinidis, Agapios; Hescheler, Juergen; Hummel, Oliver; Huebner, Norbert; Kolde, Raivo; Vilo, Jaak; Schulz, Herbert; Boeuf, Hélène |
| Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives. |
| BMC Genomics, 10, no. 73, pp. 1-20, (2009) |
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| Sedello, Anna |
| Loss-of-Function screen for proteins cooperating with Runx1 in hematopoiesis and leukemogenesis |
| [Doctoral Thesis] Technische Universität Dresden, (2009) |
| Krastev, Dragomir |
| An RNA interference synthetic interaction screen identifies vulnerability factors for TP53 mutant cells |
| [Doctoral Thesis] Technische Universität Dresden, (2009) |
| 2008 |
| Slabicki, Mikolaj |
| A systematic investigation of DNA double strand break repair by a genome-wide RNAi screen in human cells |
| [Doctoral Thesis] Technische Universität Dresden, (2008) |
| Kittler, Ralf; Pelletier, Laurence; Buchholz, Frank |
| Systems biology of mammalian cell division. |
| Cell Cycle, 7, no. 14, pp. 2123-2128, (2008) |
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| Poser, Ina; Sarov, Mihail; Hutchins, James R A; Hériché, Jean-Karim; Toyoda, Yusuke; Pozniakovsky, Andrei I.; Weigl, Daniela; Nitzsche, Anja; Hegemann, Björn; Bird, Alexander W.; Pelletier, Laurence; Kittler, Ralf; Hua, Sujun; Naumann, Ronald; Augsburg, Martina; Sykora, Martina M; Hofemeister, Helmut; Zhang, Youming; Nasmyth, Kim; White, Kevin P; Dietzel, Steffen; Mechtler, Karl; Durbin, Richard; Stewart, A. Francis; Peters, Jan-Michael; Buchholz, Frank; Hyman, Anthony A. |
| BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. |
| Nat. Methods, 5, no. 5, pp. 409-415, (2008) |
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| 2007 |
| Kittler, Ralf; Pelletier, Laurence; Heninger, Anne-Kristin; Slabicki, Mikolaj; Theis, Mirko; Miroslaw, Lukasz; Poser, Ina; Lawo, Steffen; Grabner, Hannes; Kozak, Karol; Wagner, Jan; Surendranath, Vineeth; Richter, Constance; Bowen, Wayne; Jackson, Aimee L; Habermann, Bianca; Hyman, Anthony A.; Buchholz, Frank |
| Genome-scale RNAi profiling of cell division in human tissue culture cells. |
| Nat. Cell Biol., 9, no. 12, pp. 1401-1412, (2007) |
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| Sarkar, Indrani; Hauber, Ilona; Hauber, Joachim; Buchholz, Frank |
| HIV-1 proviral DNA excision using an evolved recombinase. |
| Science, 316, no. 5833, pp. 1912-1915, (2007) |
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| Kittler, Ralf; Surendranath, Vineeth; Heninger, Anne-Kristin; Slabicki, Mikolaj; Theis, Mirko; Putz, Gabriele; Franke, Kristin; Caldarelli, Antonio; Grabner, Hannes; Kozak, Karol; Wagner, Jan; Rees, Effi; Korn, Bernd; Frenzel, Corina; Sachse, Christoph; Sönnichsen, Birte; Guo, Jun; Schelter, Janell; Burchard, Julja; Linsley, Peter S; Jackson, Aimee L; Habermann, Bianca; Buchholz, Frank |
| Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies. |
| Nat. Methods, 4, no. 4, pp. 337-344, (2007) |
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| Gregan, Juraj; Riedel, Christian G.; Petronczki, Mark; Cipak, Lubos; Rumpf, Cornelia; Poser, Ina; Buchholz, Frank; Mechtler, Karl; Nasmyth, Kim |
| Tandem affinity purification of functional TAP-tagged proteins from human cells. |
| Nat Protoc, 2, no. 5, pp. 1145-1151, (2007) |
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| Cammenga, Jörg; Niebuhr, Birte; Horn, Stefan; Bergholz, Ulla; Putz, Gabriele; Buchholz, Frank; Löhler, Jürgen; Stocking, Carol |
| RUNX1 DNA-binding mutants, associated with minimally differentiated acute myelogenous leukemia, disrupt myeloid differentiation. |
| Cancer Res., 67, no. 2, pp. 537-545, (2007) |
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| 2006 |
| Echeverri, Christophe J.; Beachy, Philip A; Baum, Buzz; Boutros, Michael; Buchholz, Frank; Chanda, Sumit K; Downward, Julian; Ellenberg, Jan; Fraser, Andrew G; Hacohen, Nir; Hahn, William C; Jackson, Aimee L; Kiger, Amy; Linsley, Peter S; Lum, Lawrence; Ma, Yong; Mathey-Prévôt, Bernard; Root, David E; Sabatini, David M; Taipale, Jussi; Perrimon, Norbert; Bernards, René |
| Minimizing the risk of reporting false positives in large-scale RNAi screens. |
| Nat. Methods, 3, no. 10, pp. 777-779, (2006) |
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| Buchholz, Frank; Kittler, Ralf; Slabicki, Mikolaj; Theis, Mirko |
| Enzymatically prepared RNAi libraries. |
| Nat. Methods, 3, no. 9, pp. 696-700, (2006) |
| Download PDF |
| Riedel, Christian G.; Katis, Vittorio L; Katou, Yuki; Mori, Saori; Itoh, Takehiko; Helmhart, Wolfgang; Gálová, Marta; Petronczki, Mark; Gregan, Juraj; Cetin, Bulent; Mudrak, Ingrid; Ogris, Egon; Mechtler, Karl; Pelletier, Laurence; Buchholz, Frank; Shirahige, Katsuhiko; Nasmyth, Kim |
| Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. |
| Nature, 441, no. 7089, pp. 53-61, (2006) |
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| Putz, Gabriele; Rosner, Andrea; Nuesslein, Ina; Schmitz, Nicole; Buchholz, Frank |
| AML1 deletion in adult mice causes splenomegaly and lymphomas. |
| Oncogene, 25, no. 6, pp. 929-939, (2006) |
| Download PDF |
| Ding, Li; Buchholz, Frank |
| RNAi in embryonic stem cells. |
| Stem cell reviews, 2, no. 1, pp. 11-18, (2006) |
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| Kittler, Ralf |
| Functional genomic analysis of cell cycle progression in human tissue culture cells |
| [Doctoral Thesis] Technische Universität Dresden, (2006) |
| Poser, Ina; Buchholz, Frank |
| A new approach to specify RNAi experiments |
| European Pharmaceutical Review, 3, pp. 12-17, (2006) |
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| 2005 |
| Kittler, Ralf; Heninger, Anne-Kristin; Franke, Kristin; Habermann, Bianca; Buchholz, Frank |
| Production of endoribonuclease-prepared short interfering RNAs for gene silencing in mammalian cells. |
| Nat. Methods, 2, no. 10, pp. 779-784, (2005) |
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| Zhang, Dong Ji; Wang, Qi; Wei, Jie; Baimukanova, Gyulnar; Buchholz, Frank; Stewart, A. Francis; Mao, Xiaohong; Killeen, Nigel |
| Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene. |
| J. Immunol., 174, no. 11, pp. 6725-6731, (2005) |
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| Kittler, Ralf; Buchholz, Frank |
| Functional genomic analysis of cell division by endoribonuclease-prepared siRNAs. |
| Cell Cycle, 4, no. 4, pp. 564-567, (2005) |
| Download PDF |
| Kittler, Ralf; Pelletier, Laurence; Ma, Chunling; Poser, Ina; Fischer, Steffi; Hyman, Anthony A.; Buchholz, Frank |
| RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells. |
| Proc. Natl. Acad. Sci. U.S.A., 102, no. 7, pp. 2396-2401, (2005) |
| Download PDF |
| Buchholz, Frank; Calegari, Federico; Kittler, Ralf; Huttner, Wieland B. |
| RNA interference in postimplantation mouse embryos |
| RNA interference technology: from basic science to drug development, chapt. 15, pp. 207-219, (2005) |
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| Buchholz, Frank |
| RNA-Interference in mammalian cells |
| European biotechnology newsletter, 4, pp. 39-42, (2005) |
| Buchholz, Frank; Drechsel, David N.; Ruer, Martine; Kittler, Ralf |
| Production of siRNA in vitro by enzymatic digestion of double-stranded RNA |
| Gene Silencing by RNA Interference : Technology and Application, chapt. 6, pp. 87-99, (2005) |
| Download PDF |
| Buchholz, Frank |
| Functional Genomics in Mammalian Cells by RNAi: Opportunities and Challenges |
| Laborwelt, 6, no. 2, pp. 18-21, (2005) |
| Download PDF |
| Krausz, Eberhard; Heninger, Anne-Kristin; Kittler, Ralf; Lohmann, Annett; Poser, Ina; Wagner, Jan; Franke, Kristin; Kozak, Karol; Grabner, Hannes; Buchholz, Frank |
| Eine Genom-weite RNA-Interferenz-Bibliothek für die funktionelle Charakterisierung aller Gene in kultivierten, menschlichen Zellen |
| BIOspektrum, 11, no. 4, pp. 436-440, (2005) |
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| Miroslaw, Lukasz; Chorazyczewski, Artur; Buchholz, Frank; Kittler, Ralf |
| Correlation-based Method for Automatic Mitotic Cell Detection in Phase Contrast Microscopy |
| [Conference Paper] International Conference on Computer Recognition Systems, Rydzyna Castle, (2005) |
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| 2004 |
| Kittler, Ralf; Putz, Gabriele; Pelletier, Laurence; Poser, Ina; Heninger, Anne-Kristin; Drechsel, David N.; Fischer, Steffi; Konstantinova, Irena; Habermann, Bianca; Grabner, Hannes; Yaspo, Marie-Laure; Himmelbauer, Heinz; Korn, Bernd; Neugebauer, Karla M.; Pisabarro, Maria Teresa; Buchholz, Frank |
| An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. |
| Nature, 432, no. 7020, pp. 1036-1040, (2004) |
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| Henschel, Andreas; Buchholz, Frank; Habermann, Bianca |
| DEQOR: a web-based tool for the design and quality control of siRNAs. |
| Nucleic Acids Res., 32, no. Web Server issue, pp. 113-120, (2004) |
| Download PDF |
| Krönke, Jan; Kittler, Ralf; Buchholz, Frank; Windisch, Marc P; Pietschmann, Thomas; Bartenschlager, Ralf; Frese, Michael |
| Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs. |
| J. Virol., 78, no. 7, pp. 3436-3446, (2004) |
| Download PDF |
| Calegari, Federico; Marzesco, Anne-Marie; Kittler, Ralf; Buchholz, Frank; Huttner, Wieland B. |
| Tissue-specific RNA interference in post-implantation mouse embryos using directional electroporation and whole embryo culture. |
| Differentiation, 72, no. 2-3, pp. 92-102, (2004) |
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| Rees, Effi; Korn, Bernd; Buchholz, Frank |
| Genfunktionsanalyse im Genom-weiten Maßstab mit 'small interfering' RNAs |
| Laborwelt, 5, no. 1, pp. 21-22, (2004) |
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| 2003 |
| Ennifar, Eric; Meyer, Joachim E W; Buchholz, Frank; Stewart, A. Francis; Suck, Dietrich |
| Crystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative mechanism for DNA cleavage activation. |
| Nucleic Acids Res., 31, no. 18, pp. 5449-5460, (2003) |
| Download PDF |
| Kittler, Ralf; Buchholz, Frank |
| RNA interference: gene silencing in the fast lane. |
| Semin. Cancer Biol., 13, no. 4, pp. 259-265, (2003) |
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| 2002 |
| Yang, Dun; Buchholz, Frank; Huang, Zhongdong; Goga, Andrei; Chen, Chih-Ying; Brodsky, Frances M; Bishop, J Michael |
| Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. |
| Proc. Natl. Acad. Sci. U.S.A., 99, no. 15, pp. 9942-9947, (2002) |
| Download PDF |
| Shimshek, D R; Kim, J; Hübner, M R; Spergel, D J; Buchholz, Frank; Casanova, E; Stewart, A. Francis; Seeburg, P H; Sprengel, R. |
| Codon-improved Cre recombinase (iCre) expression in the mouse. |
| Genesis, 32, no. 1, pp. 19-26, (2002) |
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