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Matthias Bochtler

Publications

2011
Sokolowska, Monika; Czapinska, Honorata; Bochtler, Matthias
Hpy188I-DNA pre- and post-cleavage complexes--snapshots of the GIY-YIG nuclease mediated catalysis.
Nucleic Acids Res., 39, no. 4, pp. 1554-1564, (2011)
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Antonczak, Alicja K; Simova, Zuzana; Yonemoto, Isaac T; Bochtler, Matthias; Piasecka, Anna; Czapinska, Honorata; Brancale, Andrea; Tippmann, Eric M
Importance of single molecular determinants in the fidelity of expanded genetic codes.
Proc. Natl. Acad. Sci. U.S.A., 108, no. 4, pp. 1320-1325, (2011)
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Firczuk, Malgorzata; Wojciechowski, Marek; Czapinska, Honorata; Bochtler, Matthias
DNA intercalation without flipping in the specific ThaI-DNA complex.
Nucleic Acids Res., 39, no. 2, pp. 744-754, (2011)
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2010
Piano, Dario; Alaoui, Sabah El; Korza, Henryk J; Filipek, Renata; Sabala, Izabela; Haniewicz, Patrycja; Buechel, Claudia; Sanctis, Daniele De; Bochtler, Matthias
Crystallization of the photosystem II core complex and its chlorophyll binding subunit CP43 from transplastomic plants of Nicotiana tabacum.
Photosyn. Res., 106, no. 3, pp. 221-226, (2010)
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Chojnowski, Grzegorz; Bochtler, Matthias
DIBER: protein, DNA or both?
Acta Crystallogr. D Biol. Crystallogr., 66, no. Pt 6, pp. 643-653, (2010)
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Gentsch, Marcus; Kaczmarczyk, Aneta; Leeuwen, Karin van; Boer, Martin de; Kaus-Drobek, Magdalena; Dagher, Marie-Claire; Kaiser, Petra; Arkwright, Peter D; Gahr, Manfred; Rösen-Wolff, Angela; Bochtler, Matthias; Secord, Elizabeth; Britto-Williams, Pamela; Saifi, Gulam Mustafa; Maddalena, Anne; Dbaibo, Ghassan; Bustamante, Jacinta; Casanova, Jean-Laurent; Roos, Dirk; Roesler, Joachim
Alu-repeat-induced deletions within the NCF2 gene causing p67-phox-deficient chronic granulomatous disease (CGD).
Hum. Mutat., 31, no. 2, pp. 151-158, (2010)
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Chojnowski, Grzegorz; Breer, Katarzyna; Narczyk, Marta; Wielgus-Kutrowska, Beata; Czapinska, Honorata; Hashimoto, Mariko; Hikishima, Sadao; Yokomatsu, Tsutomu; Bochtler, Matthias; Girstun, Agnieszka; Staron, Krzysztof; Bzowska, Agnieszka
1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.
Biochem. Biophys. Res. Commun., 391, no. 1, pp. 703-708, (2010)
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2009
Sokolowska, Monika; Czapinska, Honorata; Bochtler, Matthias
Crystal structure of the beta beta alpha-Me type II restriction endonuclease Hpy99I with target DNA.
Nucleic Acids Res., 37, no. 11, pp. 3799-3810, (2009)
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2008
Tamulaitis, Gintautas; Zaremba, Mindaugas; Szczepanowski, Roman H; Bochtler, Matthias; Siksnys, Virginijus
How PspGI, catalytic domain of EcoRII and Ecl18kI acquire specificities for different DNA targets.
Nucleic Acids Res., 36, no. 19, pp. 6101-6108, (2008)
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Szczepanowski, Roman H; Carpenter, Michael A; Czapinska, Honorata; Zaremba, Mindaugas; Tamulaitis, Gintautas; Siksnys, Virginijus; Bhagwat, Ashok S.; Bochtler, Matthias
Central base pair flipping and discrimination by PspGI.
Nucleic Acids Res., 36, no. 19, pp. 6109-6117, (2008)
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Sukackaite, Rasa; Grazulis, Saulius; Bochtler, Matthias; Siksnys, Virginijus
The recognition domain of the BpuJI restriction endonuclease in complex with cognate DNA at 1.3-A resolution.
J. Mol. Biol., 378, no. 5, pp. 1084-1093, (2008)
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Lipka, Magdalena; Filipek, Renata; Bochtler, Matthias
Crystal structure and mechanism of the Staphylococcus cohnii virginiamycin B lyase (Vgb).
Biochemistry, 47, no. 14, pp. 4257-4265, (2008)
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Breer, Katarzyna; Wielgus-Kutrowska, Beata; Hashimoto, Mariko; Hikishima, Sadao; Yokomatsu, Tsutomu; Szczepanowski, Roman H; Bochtler, Matthias; Girstun, Agnieszka; Staron, Krzysztof; Bzowska, Agnieszka
Thermodynamic studies of interactions of calf spleen PNP with acyclic phosphonate inhibitors.
Nucleic Acids Symp Ser (Oxf), no. 52, pp. 663-664, (2008)
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2007
Firczuk, Malgorzata; Bochtler, Matthias
Folds and activities of peptidoglycan amidases.
FEMS Microbiol. Rev., 31, no. 6, pp. 676-691, (2007)
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Sokolowska, Monika; Kaus-Drobek, Magdalena; Czapinska, Honorata; Tamulaitis, Gintautas; Siksnys, Virginijus; Bochtler, Matthias
Restriction endonucleases that resemble a component of the bacterial DNA repair machinery.
Cell. Mol. Life Sci., 64, no. 18, pp. 2351-2357, (2007)
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Chojnowski, Grzegorz; Bochtler, Matthias
The statistics of the highest E value.
Acta Crystallogr., A, Found. Crystallogr., 63, no. Pt 4, pp. 297-305, (2007)
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Sokolowska, Monika; Kaus-Drobek, Magdalena; Czapinska, Honorata; Tamulaitis, Gintautas; Szczepanowski, Roman H; Urbanke, Claus; Siksnys, Virginijus; Bochtler, Matthias
Monomeric restriction endonuclease BcnI in the apo form and in an asymmetric complex with target DNA.
J. Mol. Biol., 369, no. 3, pp. 722-734, (2007)
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Bochtler, Matthias; Chojnowski, Grzegorz
The highest reflection intensity in a resolution shell.
Acta Crystallogr., A, Found. Crystallogr., 63, no. Pt 2, pp. 146-155, (2007)
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Kaus-Drobek, Magdalena; Czapinska, Honorata; Sokolowska, Monika; Tamulaitis, Gintautas; Szczepanowski, Roman H; Urbanke, Claus; Siksnys, Virginijus; Bochtler, Matthias
Restriction endonuclease MvaI is a monomer that recognizes its target sequence asymmetrically.
Nucleic Acids Res., 35, no. 6, pp. 2035-2046, (2007)
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Tamulaitis, Gintautas; Zaremba, Mindaugas; Szczepanowski, Roman H; Bochtler, Matthias; Siksnys, Virginijus
Nucleotide flipping by restriction enzymes analyzed by 2-aminopurine steady-state fluorescence.
Nucleic Acids Res., 35, no. 14, pp. 4792-4799, (2007)
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Firczuk, Malgorzata; Bochtler, Matthias
Mutational analysis of peptidoglycan amidase MepA.
Biochemistry, 46, no. 1, pp. 120-128, (2007)
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2006
Bochtler, Matthias; Szczepanowski, Roman H; Tamulaitis, Gintautas; Grazulis, Saulius; Czapinska, Honorata; Manakova, Elena; Siksnys, Virginijus
Nucleotide flips determine the specificity of the Ecl18kI restriction endonuclease.
EMBO J., 25, no. 10, pp. 2219-2229, (2006)
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2005
Korza, Henryk J; Bochtler, Matthias
Pseudomonas aeruginosa LD-carboxypeptidase, a serine peptidase with a Ser-His-Glu triad and a nucleophilic elbow.
J. Biol. Chem., 280, no. 49, pp. 40802-40812, (2005)
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Firczuk, Malgorzata; Mucha, Artur; Bochtler, Matthias
Crystal structures of active LytM.
J. Mol. Biol., 354, no. 3, pp. 578-590, (2005)
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Odintsov, Sergey G; Sabala, Izabela; Bourenkov, Gleb; Rybin, Vladimir; Bochtler, Matthias
Substrate access to the active sites in aminopeptidase T, a representative of a new metallopeptidase clan.
J. Mol. Biol., 354, no. 2, pp. 403-412, (2005)
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Grazulis, Saulius; Manakova, Elena; Roessle, Manfred; Bochtler, Matthias; Tamulaitiene, Giedre; Huber, Robert; Siksnys, Virginijus
Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease.
Proc. Natl. Acad. Sci. U.S.A., 102, no. 44, pp. 15797-15802, (2005)
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Odintsov, Sergey G; Sabala, Izabela; Bourenkov, Gleb; Rybin, Vladimir; Bochtler, Matthias
Staphylococcus aureus aminopeptidase S is a founding member of a new peptidase clan.
J. Biol. Chem., 280, no. 30, pp. 27792-27799, (2005)
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Szczepanowski, Roman H; Filipek, Renata; Bochtler, Matthias
Crystal structure of a fragment of mouse ubiquitin-activating enzyme.
J. Biol. Chem., 280, no. 23, pp. 22006-22011, (2005)
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Azim, M Kamran; Goehring, Walter; Song, Hyun Kyu; Ramachandran, Ravishankar; Bochtler, Matthias; Goettig, Peter
Characterization of the HslU chaperone affinity for HslV protease.
Protein Sci., 14, no. 5, pp. 1357-1362, (2005)
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Dandanell, Gert; Szczepanowski, Roman H; Kierdaszuk, Borys; Shugar, David; Bochtler, Matthias
Escherichia coli purine nucleoside phosphorylase II, the product of the xapA gene.
J. Mol. Biol., 348, no. 1, pp. 113-125, (2005)
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Filipek, Renata; Potempa, Jan; Bochtler, Matthias
A comparison of staphostatin B with standard mechanism serine protease inhibitors.
J. Biol. Chem., 280, no. 15, pp. 14669-14674, (2005)
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Groll, Michael; Bochtler, Matthias; Brandstetter, Hans; Clausen, Tim; Huber, Robert
Molecular machines for protein degradation.
Chembiochem, 6, no. 2, pp. 222-256, (2005)
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2004
Filipek, Renata; Szczepanowski, Roman H; Sabat, Artur; Potempa, Jan; Bochtler, Matthias
Prostaphopain B structure: a comparison of proregion-mediated and staphostatin-mediated protease inhibition.
Biochemistry, 43, no. 44, pp. 14306-14315, (2004)
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Marcyjaniak, Malgorzata; Odintsov, Sergey G; Sabala, Izabela; Bochtler, Matthias
Peptidoglycan amidase MepA is a LAS metallopeptidase.
J. Biol. Chem., 279, no. 42, pp. 43982-43989, (2004)
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Bochtler, Matthias; Odintsov, Sergey G; Marcyjaniak, Malgorzata; Sabala, Izabela
Similar active sites in lysostaphins and D-Ala-D-Ala metallopeptidases.
Protein Sci., 13, no. 4, pp. 854-861, (2004)
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Odintsov, Sergey G; Sabala, Izabela; Marcyjaniak, Malgorzata; Bochtler, Matthias
Latent LytM at 1.3A resolution.
J. Mol. Biol., 335, no. 3, pp. 775-785, (2004)
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2003
Dubin, Grzegorz; Krajewski, Marcin; Popowicz, Grzegorz; Stec-Niemczyk, Justyna; Bochtler, Matthias; Potempa, Jan; Dubin, Adam; Holak, Tad A
A novel class of cysteine protease inhibitors: solution structure of staphostatin A from Staphylococcus aureus.
Biochemistry, 42, no. 46, pp. 13449-13456, (2003)
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Filipek, Renata; Rzychon, Malgorzata; Oleksy, Aneta; Gruca, Milosz; Dubin, Adam; Potempa, Jan; Bochtler, Matthias
The Staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease.
J. Biol. Chem., 278, no. 42, pp. 40959-40966, (2003)
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Rzychon, Malgorzata; Filipek, Renata; Sabat, Artur; Kosowska, Klaudia; Dubin, Adam; Potempa, Jan; Bochtler, Matthias
Staphostatins resemble lipocalins, not cystatins in fold.
Protein Sci., 12, no. 10, pp. 2252-2256, (2003)
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Song, Hyun Kyu; Bochtler, Matthias; Azim, M Kamran; Hartmann, Claudia; Huber, Robert; Ramachandran, Ravishankar
Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV.
Biophys. Chem., 100, no. 1-3, pp. 437-452, (2003)
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2002
Ramachandran, Ravishankar; Hartmann, Claudia; Song, Hyun Kyu; Huber, Robert; Bochtler, Matthias
Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY).
Proc. Natl. Acad. Sci. U.S.A., 99, no. 11, pp. 7396-7401, (2002)
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2001
Bochtler, Matthias; Song, Hyun Kyu; Hartmann, Claudia; Ramachandran, Ravishankar; Huber, Robert
The quaternary arrangement of HslU and HslV in a cocrystal: a response to Wang, Yale.
J. Struct. Biol., 135, no. 3, pp. 281-293, (2001)
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2000
Song, Hyun Kyu; Hartmann, Claudia; Ramachandran, Ravishankar; Bochtler, Matthias; Behrendt, Raymond; Moroder, Luis; Huber, Robert
Mutational studies on HslU and its docking mode with HslV.
Proc. Natl. Acad. Sci. U.S.A., 97, no. 26, pp. 14103-14108, (2000)
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